Alteration in proportions of histone H1 variants during the differentiation of murine erythroleukaemic cells
We have investigated the changes in the relative amounts of histone H1 zero and all five H1 variants during the differentiation in vitro of Friend erythroleukaemic cells. Three different agents were used as inducers of differentiation: dimethyl sulphoxide, hexamethylenebisacetamide and sodium butyra...
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| Veröffentlicht in: | Biochemical journal 1992-12, Vol.288 (3), p.747-751 |
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| creator | HELLIGER, W LINDNER, H GRÜBL-KNOSP, O PUSCHENDORF, B |
| description | We have investigated the changes in the relative amounts of histone H1 zero and all five H1 variants during the differentiation in vitro of Friend erythroleukaemic cells. Three different agents were used as inducers of differentiation: dimethyl sulphoxide, hexamethylenebisacetamide and sodium butyrate. By applying a combination of reverse-phase h.p.l.c. and one-dimensional gel electrophoresis we observed that, during differentiation in vitro, (1) the relative amount of each subtype changes upon induction and that (2) dimethyl sulphoxide and hexamethylenebisacetamide produce a similar histone H1 pattern with a strong increase in histones H1 zero and H1c, a modest increase in histone H1e and a decrease in the relative amounts of histone H1a, H1b and H1d, whereas butyrate induces a different pattern, particularly with respect to both histones H1c and H1e: H1c increased slightly, and H1e strongly, during differentiation. These results are compared with changes in the histone H1 pattern during differentiation in vivo in the mouse [Lennox & Cohen (1983) J. Biol. Chem. 258, 262-268] and in the rat [Pina, Martinez & Suau (1987) Eur. J. Biochem. 164, 71-76], and similarities and deviations are discussed. |
| doi_str_mv | 10.1042/bj2880747 |
| format | Article |
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Three different agents were used as inducers of differentiation: dimethyl sulphoxide, hexamethylenebisacetamide and sodium butyrate. By applying a combination of reverse-phase h.p.l.c. and one-dimensional gel electrophoresis we observed that, during differentiation in vitro, (1) the relative amount of each subtype changes upon induction and that (2) dimethyl sulphoxide and hexamethylenebisacetamide produce a similar histone H1 pattern with a strong increase in histones H1 zero and H1c, a modest increase in histone H1e and a decrease in the relative amounts of histone H1a, H1b and H1d, whereas butyrate induces a different pattern, particularly with respect to both histones H1c and H1e: H1c increased slightly, and H1e strongly, during differentiation. These results are compared with changes in the histone H1 pattern during differentiation in vivo in the mouse [Lennox & Cohen (1983) J. Biol. Chem. 258, 262-268] and in the rat [Pina, Martinez & Suau (1987) Eur. J. Biochem. 164, 71-76], and similarities and deviations are discussed.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj2880747</identifier><identifier>PMID: 1471988</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Acetamides - pharmacology ; Animals ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Butyrates - pharmacology ; Butyric Acid ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; Cell differentiation, maturation, development, hematopoiesis ; Cell Division - drug effects ; Cell Division - physiology ; Cell physiology ; Chromatography, High Pressure Liquid - methods ; Dimethyl Sulfoxide - pharmacology ; Electrophoresis - methods ; Fundamental and applied biological sciences. Psychology ; Genetic Variation - physiology ; Hemoglobins - metabolism ; Histones - analysis ; Histones - genetics ; Histones - metabolism ; Leukemia, Erythroblastic, Acute - drug therapy ; Leukemia, Erythroblastic, Acute - pathology ; Mice ; Molecular and cellular biology ; Time Factors ; Tumor Cells, Cultured - drug effects</subject><ispartof>Biochemical journal, 1992-12, Vol.288 (3), p.747-751</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3147-5545ee6242694995d15661f17e5776ee095eb378cf0091079d69421a6ca8a5943</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1131949/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1131949/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4444744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1471988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HELLIGER, W</creatorcontrib><creatorcontrib>LINDNER, H</creatorcontrib><creatorcontrib>GRÜBL-KNOSP, O</creatorcontrib><creatorcontrib>PUSCHENDORF, B</creatorcontrib><title>Alteration in proportions of histone H1 variants during the differentiation of murine erythroleukaemic cells</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>We have investigated the changes in the relative amounts of histone H1 zero and all five H1 variants during the differentiation in vitro of Friend erythroleukaemic cells. Three different agents were used as inducers of differentiation: dimethyl sulphoxide, hexamethylenebisacetamide and sodium butyrate. By applying a combination of reverse-phase h.p.l.c. and one-dimensional gel electrophoresis we observed that, during differentiation in vitro, (1) the relative amount of each subtype changes upon induction and that (2) dimethyl sulphoxide and hexamethylenebisacetamide produce a similar histone H1 pattern with a strong increase in histones H1 zero and H1c, a modest increase in histone H1e and a decrease in the relative amounts of histone H1a, H1b and H1d, whereas butyrate induces a different pattern, particularly with respect to both histones H1c and H1e: H1c increased slightly, and H1e strongly, during differentiation. These results are compared with changes in the histone H1 pattern during differentiation in vivo in the mouse [Lennox & Cohen (1983) J. Biol. Chem. 258, 262-268] and in the rat [Pina, Martinez & Suau (1987) Eur. J. Biochem. 164, 71-76], and similarities and deviations are discussed.</description><subject>Acetamides - pharmacology</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Butyrates - pharmacology</subject><subject>Butyric Acid</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell Division - drug effects</subject><subject>Cell Division - physiology</subject><subject>Cell physiology</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Dimethyl Sulfoxide - pharmacology</subject><subject>Electrophoresis - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation - physiology</subject><subject>Hemoglobins - metabolism</subject><subject>Histones - analysis</subject><subject>Histones - genetics</subject><subject>Histones - metabolism</subject><subject>Leukemia, Erythroblastic, Acute - drug therapy</subject><subject>Leukemia, Erythroblastic, Acute - pathology</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Time Factors</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1KAzEUhYMoWn8WPoCQhQguRpOZZDLZCEXUCgU3ug5p5o5NnUlqMlPo25vSUjWbEM6Xc8_lIHRJyR0lLL-fLfKqIoKJAzSiTJCsEnl1iEYkL1lWkpyeoNMYF4RQRhg5RscJorKqRqgdtz0E3VvvsHV4GfzSh80rYt_guY29d4AnFK90sNr1EddDsO4T93PAtW0aCOB6uzVIP7qNChjCup8H38LwpaGzBhto23iOjhrdRrjY3Wfo4_np_XGSTd9eXh_H08wUKVjGOeMAZc7yUjIpeU15WdKGCuBClABEcpgVojINIZISIevE5VSXRleaS1acoYet73KYdVCblDDoVi2D7XRYK6-t-q84O1effqUoLWgamQxudgbBfw8Qe9XZuFlBO_BDVKJgXHJGEni7BU3wMQZo9kMoUZtq1L6axF79TfVLbrtI-vVO19HotgnaGRv3GEtHMFb8AHVSl6o</recordid><startdate>19921215</startdate><enddate>19921215</enddate><creator>HELLIGER, W</creator><creator>LINDNER, H</creator><creator>GRÜBL-KNOSP, O</creator><creator>PUSCHENDORF, B</creator><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19921215</creationdate><title>Alteration in proportions of histone H1 variants during the differentiation of murine erythroleukaemic cells</title><author>HELLIGER, W ; LINDNER, H ; GRÜBL-KNOSP, O ; PUSCHENDORF, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3147-5545ee6242694995d15661f17e5776ee095eb378cf0091079d69421a6ca8a5943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acetamides - pharmacology</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Butyrates - pharmacology</topic><topic>Butyric Acid</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - physiology</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell Division - drug effects</topic><topic>Cell Division - physiology</topic><topic>Cell physiology</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Dimethyl Sulfoxide - pharmacology</topic><topic>Electrophoresis - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Variation - physiology</topic><topic>Hemoglobins - metabolism</topic><topic>Histones - analysis</topic><topic>Histones - genetics</topic><topic>Histones - metabolism</topic><topic>Leukemia, Erythroblastic, Acute - drug therapy</topic><topic>Leukemia, Erythroblastic, Acute - pathology</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Time Factors</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HELLIGER, W</creatorcontrib><creatorcontrib>LINDNER, H</creatorcontrib><creatorcontrib>GRÜBL-KNOSP, O</creatorcontrib><creatorcontrib>PUSCHENDORF, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HELLIGER, W</au><au>LINDNER, H</au><au>GRÜBL-KNOSP, O</au><au>PUSCHENDORF, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration in proportions of histone H1 variants during the differentiation of murine erythroleukaemic cells</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>1992-12-15</date><risdate>1992</risdate><volume>288</volume><issue>3</issue><spage>747</spage><epage>751</epage><pages>747-751</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>We have investigated the changes in the relative amounts of histone H1 zero and all five H1 variants during the differentiation in vitro of Friend erythroleukaemic cells. Three different agents were used as inducers of differentiation: dimethyl sulphoxide, hexamethylenebisacetamide and sodium butyrate. By applying a combination of reverse-phase h.p.l.c. and one-dimensional gel electrophoresis we observed that, during differentiation in vitro, (1) the relative amount of each subtype changes upon induction and that (2) dimethyl sulphoxide and hexamethylenebisacetamide produce a similar histone H1 pattern with a strong increase in histones H1 zero and H1c, a modest increase in histone H1e and a decrease in the relative amounts of histone H1a, H1b and H1d, whereas butyrate induces a different pattern, particularly with respect to both histones H1c and H1e: H1c increased slightly, and H1e strongly, during differentiation. These results are compared with changes in the histone H1 pattern during differentiation in vivo in the mouse [Lennox & Cohen (1983) J. Biol. Chem. 258, 262-268] and in the rat [Pina, Martinez & Suau (1987) Eur. J. Biochem. 164, 71-76], and similarities and deviations are discussed.</abstract><cop>Colchester</cop><pub>Portland Press</pub><pmid>1471988</pmid><doi>10.1042/bj2880747</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetamides - pharmacology Animals Antineoplastic Agents - pharmacology Biological and medical sciences Butyrates - pharmacology Butyric Acid Cell Differentiation - drug effects Cell Differentiation - physiology Cell differentiation, maturation, development, hematopoiesis Cell Division - drug effects Cell Division - physiology Cell physiology Chromatography, High Pressure Liquid - methods Dimethyl Sulfoxide - pharmacology Electrophoresis - methods Fundamental and applied biological sciences. Psychology Genetic Variation - physiology Hemoglobins - metabolism Histones - analysis Histones - genetics Histones - metabolism Leukemia, Erythroblastic, Acute - drug therapy Leukemia, Erythroblastic, Acute - pathology Mice Molecular and cellular biology Time Factors Tumor Cells, Cultured - drug effects |
| title | Alteration in proportions of histone H1 variants during the differentiation of murine erythroleukaemic cells |
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