Prognostic Significance of Synchronous Colorectal Adenocarcinoma: A Matched-Pair Analysis
To determine the prognostic significance of the synchronous colorectal cancer (S-CRC) on survival and recurrence rate. Authors conducted an analysis of 90 colorectal adenocarcinoma patients who received a curative (R0) resection with a full course of standard adjuvant treatment. A total of 45 patien...
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| Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2024-05, Vol.25 (5), p.1539-1545 |
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| creator | Anannamcharoen, Sahaphol Nimmanon, Thirayost Cheeranont, Piyapan Boonya-Ussadorn, Chinakrit |
| description | To determine the prognostic significance of the synchronous colorectal cancer (S-CRC) on survival and recurrence rate.
Authors conducted an analysis of 90 colorectal adenocarcinoma patients who received a curative (R0) resection with a full course of standard adjuvant treatment. A total of 45 patients diagnosed with S-CRC at the time of initial presentation were individually matched to a group of 45 solitary CRC patients in pair at a ratio of 1:1. The case-matched criteria included age (± 5 years), gender, tumor location, and tumor stage. For S-CRC, the most advanced pathologic lesion was defined as the index lesion, and the matching cancer stage was categorized according to the index lesion. The N-stage was determined based on all lymph nodes.
There were a higher number of retrieved nodes in patients with S-CRC than those with solitary CRC. The median (min, max) of the total number of retrieved nodes for S-CRC was 18 (3, 53) nodes, compared to 14 (4, 45) nodes for solitary CRC (p < 0.01). All patients were without distant metastasis (stage I to III). The total accumulative number of patients experiencing tumor recurrence was 9 (20%) amongst the solitary CRC patients and 18 (40%) amongst the S-CRC patients at the 15-year surveillance period (p |
| doi_str_mv | 10.31557/APJCP.2024.25.5.1539 |
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Authors conducted an analysis of 90 colorectal adenocarcinoma patients who received a curative (R0) resection with a full course of standard adjuvant treatment. A total of 45 patients diagnosed with S-CRC at the time of initial presentation were individually matched to a group of 45 solitary CRC patients in pair at a ratio of 1:1. The case-matched criteria included age (± 5 years), gender, tumor location, and tumor stage. For S-CRC, the most advanced pathologic lesion was defined as the index lesion, and the matching cancer stage was categorized according to the index lesion. The N-stage was determined based on all lymph nodes.
There were a higher number of retrieved nodes in patients with S-CRC than those with solitary CRC. The median (min, max) of the total number of retrieved nodes for S-CRC was 18 (3, 53) nodes, compared to 14 (4, 45) nodes for solitary CRC (p < 0.01). All patients were without distant metastasis (stage I to III). The total accumulative number of patients experiencing tumor recurrence was 9 (20%) amongst the solitary CRC patients and 18 (40%) amongst the S-CRC patients at the 15-year surveillance period (p<0.05). The disease-free survival (DFS) (mean + SD) was 147.6 + 9.3 months in the solitary CRC group, compared to 110.5 + 11.7 months in the S-CRC group (p<0.05). Amongst S-CRC patients, those having primary and synchronous tumors located across anatomical segments had poorer DFS (70.5 months) and higher 15-year tumor recurrence rate (17.8%) than those with all tumors in the same or contiguous anatomical segments. In addition, the S-CRC patients with all tumors located in contiguous segment had a longer DFS (123.7 months) than the other types of anatomical correlation.
Patients with S-CRC had worse prognosis than those with solitary CRC. For S-CRC, the anatomical correlation between the primary and the synchronous tumors may influence DFS and recurrence rate.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2024.25.5.1539</identifier><identifier>PMID: 38809625</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adult ; Aged ; Case-Control Studies ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Female ; Follow-Up Studies ; Humans ; Lymphatic Metastasis ; Male ; Matched-Pair Analysis ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Neoplasms, Multiple Primary - mortality ; Neoplasms, Multiple Primary - pathology ; Prognosis ; Survival Rate</subject><ispartof>Asian Pacific Journal of Cancer Prevention, 2024-05, Vol.25 (5), p.1539-1545</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000000187651268 ; 0000000261332602 ; 000000030274564X ; 0000000247595916</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318822/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318822/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38809625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anannamcharoen, Sahaphol</creatorcontrib><creatorcontrib>Nimmanon, Thirayost</creatorcontrib><creatorcontrib>Cheeranont, Piyapan</creatorcontrib><creatorcontrib>Boonya-Ussadorn, Chinakrit</creatorcontrib><title>Prognostic Significance of Synchronous Colorectal Adenocarcinoma: A Matched-Pair Analysis</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>To determine the prognostic significance of the synchronous colorectal cancer (S-CRC) on survival and recurrence rate.
Authors conducted an analysis of 90 colorectal adenocarcinoma patients who received a curative (R0) resection with a full course of standard adjuvant treatment. A total of 45 patients diagnosed with S-CRC at the time of initial presentation were individually matched to a group of 45 solitary CRC patients in pair at a ratio of 1:1. The case-matched criteria included age (± 5 years), gender, tumor location, and tumor stage. For S-CRC, the most advanced pathologic lesion was defined as the index lesion, and the matching cancer stage was categorized according to the index lesion. The N-stage was determined based on all lymph nodes.
There were a higher number of retrieved nodes in patients with S-CRC than those with solitary CRC. The median (min, max) of the total number of retrieved nodes for S-CRC was 18 (3, 53) nodes, compared to 14 (4, 45) nodes for solitary CRC (p < 0.01). All patients were without distant metastasis (stage I to III). The total accumulative number of patients experiencing tumor recurrence was 9 (20%) amongst the solitary CRC patients and 18 (40%) amongst the S-CRC patients at the 15-year surveillance period (p<0.05). The disease-free survival (DFS) (mean + SD) was 147.6 + 9.3 months in the solitary CRC group, compared to 110.5 + 11.7 months in the S-CRC group (p<0.05). Amongst S-CRC patients, those having primary and synchronous tumors located across anatomical segments had poorer DFS (70.5 months) and higher 15-year tumor recurrence rate (17.8%) than those with all tumors in the same or contiguous anatomical segments. In addition, the S-CRC patients with all tumors located in contiguous segment had a longer DFS (123.7 months) than the other types of anatomical correlation.
Patients with S-CRC had worse prognosis than those with solitary CRC. For S-CRC, the anatomical correlation between the primary and the synchronous tumors may influence DFS and recurrence rate.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Multiple Primary - mortality</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Prognosis</subject><subject>Survival Rate</subject><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkFtLwzAUgIMobk5_gpI_0JpL04svUopXJhamoE8hTZMt0iUj6YT9e3fRMZ_OgcP3HfgAuMQoppix7Lqsn6s6JogkMWExizGjxREYkiRLoywlH8cH-wCchfCFUMLyjJ2CAc1zVKSEDcFn7d3UutAbCSdmao02UlipoNNwsrJy5p11ywAr1zmvZC86WLbKOim8NNbNxQ0s4Yvo5Uy1US2Mh6UV3SqYcA5OtOiCuvidI_B-f_dWPUbj14enqhxHkiBWRBTrRhRIqwSxREtBE5IqjBUhTaELLJtEYlYoKpRClKm2TdqU5hqJNG9omlI6Arc772LZzFUrle296PjCm7nwK-6E4f8v1sz41H1zjCnOc0LWBrYzSO9C8ErvYYz4Njbfxuab2Jwwzvgm9pq7Ovy8p_7q0h_21X3x</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Anannamcharoen, Sahaphol</creator><creator>Nimmanon, Thirayost</creator><creator>Cheeranont, Piyapan</creator><creator>Boonya-Ussadorn, Chinakrit</creator><general>West Asia Organization for Cancer Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000000187651268</orcidid><orcidid>https://orcid.org/0000000261332602</orcidid><orcidid>https://orcid.org/000000030274564X</orcidid><orcidid>https://orcid.org/0000000247595916</orcidid></search><sort><creationdate>20240501</creationdate><title>Prognostic Significance of Synchronous Colorectal Adenocarcinoma: A Matched-Pair Analysis</title><author>Anannamcharoen, Sahaphol ; Nimmanon, Thirayost ; Cheeranont, Piyapan ; Boonya-Ussadorn, Chinakrit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2059-31fba90fe4054fca3426e11e22b9f91cb4c159e3aee035edd4d638f0a68b36633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Matched-Pair Analysis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Multiple Primary - mortality</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Prognosis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anannamcharoen, Sahaphol</creatorcontrib><creatorcontrib>Nimmanon, Thirayost</creatorcontrib><creatorcontrib>Cheeranont, Piyapan</creatorcontrib><creatorcontrib>Boonya-Ussadorn, Chinakrit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anannamcharoen, Sahaphol</au><au>Nimmanon, Thirayost</au><au>Cheeranont, Piyapan</au><au>Boonya-Ussadorn, Chinakrit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Synchronous Colorectal Adenocarcinoma: A Matched-Pair Analysis</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>25</volume><issue>5</issue><spage>1539</spage><epage>1545</epage><pages>1539-1545</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>To determine the prognostic significance of the synchronous colorectal cancer (S-CRC) on survival and recurrence rate.
Authors conducted an analysis of 90 colorectal adenocarcinoma patients who received a curative (R0) resection with a full course of standard adjuvant treatment. A total of 45 patients diagnosed with S-CRC at the time of initial presentation were individually matched to a group of 45 solitary CRC patients in pair at a ratio of 1:1. The case-matched criteria included age (± 5 years), gender, tumor location, and tumor stage. For S-CRC, the most advanced pathologic lesion was defined as the index lesion, and the matching cancer stage was categorized according to the index lesion. The N-stage was determined based on all lymph nodes.
There were a higher number of retrieved nodes in patients with S-CRC than those with solitary CRC. The median (min, max) of the total number of retrieved nodes for S-CRC was 18 (3, 53) nodes, compared to 14 (4, 45) nodes for solitary CRC (p < 0.01). All patients were without distant metastasis (stage I to III). The total accumulative number of patients experiencing tumor recurrence was 9 (20%) amongst the solitary CRC patients and 18 (40%) amongst the S-CRC patients at the 15-year surveillance period (p<0.05). The disease-free survival (DFS) (mean + SD) was 147.6 + 9.3 months in the solitary CRC group, compared to 110.5 + 11.7 months in the S-CRC group (p<0.05). Amongst S-CRC patients, those having primary and synchronous tumors located across anatomical segments had poorer DFS (70.5 months) and higher 15-year tumor recurrence rate (17.8%) than those with all tumors in the same or contiguous anatomical segments. In addition, the S-CRC patients with all tumors located in contiguous segment had a longer DFS (123.7 months) than the other types of anatomical correlation.
Patients with S-CRC had worse prognosis than those with solitary CRC. For S-CRC, the anatomical correlation between the primary and the synchronous tumors may influence DFS and recurrence rate.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>38809625</pmid><doi>10.31557/APJCP.2024.25.5.1539</doi><tpages>7</tpages><orcidid>https://orcid.org/0000000187651268</orcidid><orcidid>https://orcid.org/0000000261332602</orcidid><orcidid>https://orcid.org/000000030274564X</orcidid><orcidid>https://orcid.org/0000000247595916</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Case-Control Studies Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Female Follow-Up Studies Humans Lymphatic Metastasis Male Matched-Pair Analysis Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Staging Neoplasms, Multiple Primary - mortality Neoplasms, Multiple Primary - pathology Prognosis Survival Rate |
| title | Prognostic Significance of Synchronous Colorectal Adenocarcinoma: A Matched-Pair Analysis |
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