Evaluating the pharmacological activities of Aloe perryi–Silver nanoparticles induced apoptosis against colon cancer cells (HCT‐116)
Aloe perryi has been studied and possesses several activities, including antibacterial, antiparasitic, and anticancer properties. In this study, A. perryi was used as a reducing agent of silver ions into silver nanoparticles. Aloe perryi–silver nanoparticles (APS‐NPs) were characterized and evaluate...
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| creator | Hotan, Omar Alhaj, Ali Al‐quhaim, Abdulghfor Alburaihi, Khaled Ahmed, Yahya Munasser, Qassem Dhufer, Saleh Bin Nasran, Tammam Gabir, Mohammed Ebrahim, Akram Obadi, Mohammed Hadi, Maryam Al‐baity, Hanefa Ba‐Nafea, Abdulmalek Qaed, Eskandar Zaky, Mohamed Y. Okba, Mohammed Al‐Nasi, Abdullah Almoiliqy, Marwan |
| description | Aloe perryi has been studied and possesses several activities, including antibacterial, antiparasitic, and anticancer properties. In this study, A. perryi was used as a reducing agent of silver ions into silver nanoparticles. Aloe perryi–silver nanoparticles (APS‐NPs) were characterized and evaluated using characterization techniques. However, the antioxidative, antibacterial, and anticancer assays were studied to evaluate the pharmacological activities of APS‐NPs. APS‐NPs were developed and changed to dark brown and the maximum absorption was 442 nm. SEM (5–583 nm), TEM (4–110 nm), XRD (21.84 nm), and zeta potential analysis (63.39 nm) revealed that the APS‐NPs were nano‐sized, and the APS‐NPs had a cubic crystalline structure, according to the XRD results. FTIR analysis suggested that functional groups of A. perryi metabolites were involved in forming APS‐NPs. The zeta potential indicated that the APS‐NPs were negatively charged (−32 mV), suggesting good stability. APS‐NPs showed significant antioxidative stress activity by reducing DPPH‐free radicles in a dose‐dependent manner. APS‐NPs‐induced antibacterial effect against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Acinetobacter baumannii (A. baumannii). APS‐NPs reduced the cell viability and cell migration of the human colon tumor cell line (HCT 116) compared with controls, indicating that APS‐NPs could play a role in reducing metastasis and inducing cell apoptosis against colon cancer. In conclusion, the nanoparticle synthesis from A. perryi extract demonstrated excellent antioxidant, antibacterial, and anticancer activities, thus suggesting that our APS‐NPs have the potential to be used as antioxidative and antibacterial in food and pharmaceutical industries.
Synthesis of silver nanoparticles via using Aloe perryi as a reducing agent, and illustrating the characterization studies of Aloe perryi–silver nanoparticles and their pharmacological activity against HCT‐116 colon cancer cells. |
| doi_str_mv | 10.1002/fsn3.4246 |
| format | Article |
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Synthesis of silver nanoparticles via using Aloe perryi as a reducing agent, and illustrating the characterization studies of Aloe perryi–silver nanoparticles and their pharmacological activity against HCT‐116 colon cancer cells.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.4246</identifier><identifier>PMID: 39139937</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>A. perryi ; Aloe ; Aloe perryi ; Antibacterial activity ; Antibacterial agents ; Antibiotics ; Anticancer properties ; Antidiabetics ; Antiinfectives and antibacterials ; Antiparasitic agents ; Apoptosis ; Bacteria ; Cell migration ; Cell viability ; characterization ; Colon cancer ; Colorectal cancer ; Cosmetics ; E coli ; Food industry ; Functional groups ; Fungi ; Gram-positive bacteria ; Metabolites ; Metastases ; Microorganisms ; Microscopy ; Nanoparticles ; Nanotechnology ; Original ; Pharmaceutical industry ; pharmacological activities ; Pharmacology ; Phytochemicals ; Reducing agents ; Silver ; silver nanoparticles ; synthesis ; Toxicity ; Zeta potential</subject><ispartof>Food Science & Nutrition, 2024-08, Vol.12 (8), p.5890-5906</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>COPYRIGHT 2024 John Wiley & Sons, Inc.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4016-7adc456078784ca9d6cc469d7251193803ef685b835fe9cf3cf564c90623a7ec3</cites><orcidid>0000-0002-9068-5909</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317657/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317657/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39139937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hotan, Omar</creatorcontrib><creatorcontrib>Alhaj, Ali</creatorcontrib><creatorcontrib>Al‐quhaim, Abdulghfor</creatorcontrib><creatorcontrib>Alburaihi, Khaled</creatorcontrib><creatorcontrib>Ahmed, Yahya</creatorcontrib><creatorcontrib>Munasser, Qassem</creatorcontrib><creatorcontrib>Dhufer, Saleh Bin</creatorcontrib><creatorcontrib>Nasran, Tammam</creatorcontrib><creatorcontrib>Gabir, Mohammed</creatorcontrib><creatorcontrib>Ebrahim, Akram</creatorcontrib><creatorcontrib>Obadi, Mohammed</creatorcontrib><creatorcontrib>Hadi, Maryam</creatorcontrib><creatorcontrib>Al‐baity, Hanefa</creatorcontrib><creatorcontrib>Ba‐Nafea, Abdulmalek</creatorcontrib><creatorcontrib>Qaed, Eskandar</creatorcontrib><creatorcontrib>Zaky, Mohamed Y.</creatorcontrib><creatorcontrib>Okba, Mohammed</creatorcontrib><creatorcontrib>Al‐Nasi, Abdullah</creatorcontrib><creatorcontrib>Almoiliqy, Marwan</creatorcontrib><title>Evaluating the pharmacological activities of Aloe perryi–Silver nanoparticles induced apoptosis against colon cancer cells (HCT‐116)</title><title>Food Science & Nutrition</title><addtitle>Food Sci Nutr</addtitle><description>Aloe perryi has been studied and possesses several activities, including antibacterial, antiparasitic, and anticancer properties. In this study, A. perryi was used as a reducing agent of silver ions into silver nanoparticles. Aloe perryi–silver nanoparticles (APS‐NPs) were characterized and evaluated using characterization techniques. However, the antioxidative, antibacterial, and anticancer assays were studied to evaluate the pharmacological activities of APS‐NPs. APS‐NPs were developed and changed to dark brown and the maximum absorption was 442 nm. SEM (5–583 nm), TEM (4–110 nm), XRD (21.84 nm), and zeta potential analysis (63.39 nm) revealed that the APS‐NPs were nano‐sized, and the APS‐NPs had a cubic crystalline structure, according to the XRD results. FTIR analysis suggested that functional groups of A. perryi metabolites were involved in forming APS‐NPs. The zeta potential indicated that the APS‐NPs were negatively charged (−32 mV), suggesting good stability. APS‐NPs showed significant antioxidative stress activity by reducing DPPH‐free radicles in a dose‐dependent manner. APS‐NPs‐induced antibacterial effect against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Acinetobacter baumannii (A. baumannii). APS‐NPs reduced the cell viability and cell migration of the human colon tumor cell line (HCT 116) compared with controls, indicating that APS‐NPs could play a role in reducing metastasis and inducing cell apoptosis against colon cancer. In conclusion, the nanoparticle synthesis from A. perryi extract demonstrated excellent antioxidant, antibacterial, and anticancer activities, thus suggesting that our APS‐NPs have the potential to be used as antioxidative and antibacterial in food and pharmaceutical industries.
Synthesis of silver nanoparticles via using Aloe perryi as a reducing agent, and illustrating the characterization studies of Aloe perryi–silver nanoparticles and their pharmacological activity against HCT‐116 colon cancer cells.</description><subject>A. perryi</subject><subject>Aloe</subject><subject>Aloe perryi</subject><subject>Antibacterial activity</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Anticancer properties</subject><subject>Antidiabetics</subject><subject>Antiinfectives and antibacterials</subject><subject>Antiparasitic agents</subject><subject>Apoptosis</subject><subject>Bacteria</subject><subject>Cell migration</subject><subject>Cell viability</subject><subject>characterization</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Cosmetics</subject><subject>E coli</subject><subject>Food industry</subject><subject>Functional groups</subject><subject>Fungi</subject><subject>Gram-positive bacteria</subject><subject>Metabolites</subject><subject>Metastases</subject><subject>Microorganisms</subject><subject>Microscopy</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Original</subject><subject>Pharmaceutical industry</subject><subject>pharmacological activities</subject><subject>Pharmacology</subject><subject>Phytochemicals</subject><subject>Reducing agents</subject><subject>Silver</subject><subject>silver nanoparticles</subject><subject>synthesis</subject><subject>Toxicity</subject><subject>Zeta 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Omar</creator><creator>Alhaj, Ali</creator><creator>Al‐quhaim, Abdulghfor</creator><creator>Alburaihi, Khaled</creator><creator>Ahmed, Yahya</creator><creator>Munasser, Qassem</creator><creator>Dhufer, Saleh Bin</creator><creator>Nasran, Tammam</creator><creator>Gabir, Mohammed</creator><creator>Ebrahim, Akram</creator><creator>Obadi, Mohammed</creator><creator>Hadi, Maryam</creator><creator>Al‐baity, Hanefa</creator><creator>Ba‐Nafea, Abdulmalek</creator><creator>Qaed, Eskandar</creator><creator>Zaky, Mohamed Y.</creator><creator>Okba, Mohammed</creator><creator>Al‐Nasi, Abdullah</creator><creator>Almoiliqy, Marwan</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons 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the pharmacological activities of Aloe perryi–Silver nanoparticles induced apoptosis against colon cancer cells (HCT‐116)</title><author>Hotan, Omar ; Alhaj, Ali ; Al‐quhaim, Abdulghfor ; Alburaihi, Khaled ; Ahmed, Yahya ; Munasser, Qassem ; Dhufer, Saleh Bin ; Nasran, Tammam ; Gabir, Mohammed ; Ebrahim, Akram ; Obadi, Mohammed ; Hadi, Maryam ; Al‐baity, Hanefa ; Ba‐Nafea, Abdulmalek ; Qaed, Eskandar ; Zaky, Mohamed Y. ; Okba, Mohammed ; Al‐Nasi, Abdullah ; Almoiliqy, Marwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4016-7adc456078784ca9d6cc469d7251193803ef685b835fe9cf3cf564c90623a7ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>A. perryi</topic><topic>Aloe</topic><topic>Aloe perryi</topic><topic>Antibacterial activity</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Anticancer properties</topic><topic>Antidiabetics</topic><topic>Antiinfectives and antibacterials</topic><topic>Antiparasitic agents</topic><topic>Apoptosis</topic><topic>Bacteria</topic><topic>Cell migration</topic><topic>Cell viability</topic><topic>characterization</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Cosmetics</topic><topic>E coli</topic><topic>Food industry</topic><topic>Functional groups</topic><topic>Fungi</topic><topic>Gram-positive bacteria</topic><topic>Metabolites</topic><topic>Metastases</topic><topic>Microorganisms</topic><topic>Microscopy</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Original</topic><topic>Pharmaceutical industry</topic><topic>pharmacological activities</topic><topic>Pharmacology</topic><topic>Phytochemicals</topic><topic>Reducing agents</topic><topic>Silver</topic><topic>silver nanoparticles</topic><topic>synthesis</topic><topic>Toxicity</topic><topic>Zeta 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Hanefa</au><au>Ba‐Nafea, Abdulmalek</au><au>Qaed, Eskandar</au><au>Zaky, Mohamed Y.</au><au>Okba, Mohammed</au><au>Al‐Nasi, Abdullah</au><au>Almoiliqy, Marwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluating the pharmacological activities of Aloe perryi–Silver nanoparticles induced apoptosis against colon cancer cells (HCT‐116)</atitle><jtitle>Food Science & Nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2024-08</date><risdate>2024</risdate><volume>12</volume><issue>8</issue><spage>5890</spage><epage>5906</epage><pages>5890-5906</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>Aloe perryi has been studied and possesses several activities, including antibacterial, antiparasitic, and anticancer properties. In this study, A. perryi was used as a reducing agent of silver ions into silver nanoparticles. Aloe perryi–silver nanoparticles (APS‐NPs) were characterized and evaluated using characterization techniques. However, the antioxidative, antibacterial, and anticancer assays were studied to evaluate the pharmacological activities of APS‐NPs. APS‐NPs were developed and changed to dark brown and the maximum absorption was 442 nm. SEM (5–583 nm), TEM (4–110 nm), XRD (21.84 nm), and zeta potential analysis (63.39 nm) revealed that the APS‐NPs were nano‐sized, and the APS‐NPs had a cubic crystalline structure, according to the XRD results. FTIR analysis suggested that functional groups of A. perryi metabolites were involved in forming APS‐NPs. The zeta potential indicated that the APS‐NPs were negatively charged (−32 mV), suggesting good stability. APS‐NPs showed significant antioxidative stress activity by reducing DPPH‐free radicles in a dose‐dependent manner. APS‐NPs‐induced antibacterial effect against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Acinetobacter baumannii (A. baumannii). APS‐NPs reduced the cell viability and cell migration of the human colon tumor cell line (HCT 116) compared with controls, indicating that APS‐NPs could play a role in reducing metastasis and inducing cell apoptosis against colon cancer. In conclusion, the nanoparticle synthesis from A. perryi extract demonstrated excellent antioxidant, antibacterial, and anticancer activities, thus suggesting that our APS‐NPs have the potential to be used as antioxidative and antibacterial in food and pharmaceutical industries.
Synthesis of silver nanoparticles via using Aloe perryi as a reducing agent, and illustrating the characterization studies of Aloe perryi–silver nanoparticles and their pharmacological activity against HCT‐116 colon cancer cells.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>39139937</pmid><doi>10.1002/fsn3.4246</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-9068-5909</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2048-7177 |
| ispartof | Food Science & Nutrition, 2024-08, Vol.12 (8), p.5890-5906 |
| issn | 2048-7177 2048-7177 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11317657 |
| source | Wiley Online Library Open Access; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | A. perryi Aloe Aloe perryi Antibacterial activity Antibacterial agents Antibiotics Anticancer properties Antidiabetics Antiinfectives and antibacterials Antiparasitic agents Apoptosis Bacteria Cell migration Cell viability characterization Colon cancer Colorectal cancer Cosmetics E coli Food industry Functional groups Fungi Gram-positive bacteria Metabolites Metastases Microorganisms Microscopy Nanoparticles Nanotechnology Original Pharmaceutical industry pharmacological activities Pharmacology Phytochemicals Reducing agents Silver silver nanoparticles synthesis Toxicity Zeta potential |
| title | Evaluating the pharmacological activities of Aloe perryi–Silver nanoparticles induced apoptosis against colon cancer cells (HCT‐116) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T00%3A02%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluating%20the%20pharmacological%20activities%20of%20Aloe%20perryi%E2%80%93Silver%20nanoparticles%20induced%20apoptosis%20against%20colon%20cancer%20cells%20(HCT%E2%80%90116)&rft.jtitle=Food%20Science%20&%20Nutrition&rft.au=Hotan,%20Omar&rft.date=2024-08&rft.volume=12&rft.issue=8&rft.spage=5890&rft.epage=5906&rft.pages=5890-5906&rft.issn=2048-7177&rft.eissn=2048-7177&rft_id=info:doi/10.1002/fsn3.4246&rft_dat=%3Cgale_pubme%3EA815227643%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3091470563&rft_id=info:pmid/39139937&rft_galeid=A815227643&rfr_iscdi=true |