DNA binding and bridging by human CtIP in the healthy and diseased states

Abstract The human DNA repair factor CtIP helps to initiate the resection of double-stranded DNA breaks for repair by homologous recombination, in part through its ability to bind and bridge DNA molecules. However, CtIP is a natively disordered protein that bears no apparent similarity to other DNA-...

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Veröffentlicht in:Nucleic acids research 2024-06, Vol.52 (14), p.8303-8319
Hauptverfasser: Lokanathan Balaji, Shreya, De Bragança, Sara, Balaguer-Pérez, Francisco, Northall, Sarah, Wilkinson, Oliver John, Aicart-Ramos, Clara, Seetaloo, Neeleema, Sobott, Frank, Moreno-Herrero, Fernando, Dillingham, Mark Simon
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Sprache:eng
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