Cohesin composition and dosage independently affect early development in zebrafish

Cohesin, a chromatin-associated protein complex with four core subunits (Smc1a, Smc3, Rad21 and either Stag1 or 2), has a central role in cell proliferation and gene expression in metazoans. Human developmental disorders termed 'cohesinopathies' are characterized by germline variants of co...

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Veröffentlicht in:	Development (Cambridge) 2024-08, Vol.151 (15)
Hauptverfasser:	Labudina, Anastasia A, Meier, Michael, Gimenez, Gregory, Tatarakis, David, Ketharnathan, Sarada, Mackie, Bridget, Schilling, Thomas F, Antony, Jisha, Horsfield, Julia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Cohesins Embryonic Development - genetics Gene Dosage Gene Expression Regulation, Developmental Mesoderm - embryology Mesoderm - metabolism Mutation - genetics Wnt Signaling Pathway - genetics Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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