The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and gamma-glutamyl domains

The GSH-binding site of glutathione S-transferase (GST) isoenzymes was studied by investigating their substrate-specificity for three series of GSH analogues; further, a model of the interactions of GSH with the G-site is proposed. Twelve glycyl-modified GSH analogues, four ester derivatives of GSH...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical journal 1990-07, Vol.269 (1), p.47-54
Hauptverfasser:	Adang, A E, Brussee, J, van der Gen, A, Mulder, G J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Chemical Phenomena Chemistry Cysteine Dinitrochlorobenzene Glutamine glutathione Glutathione - analogs & derivatives Glutathione - metabolism Glutathione Transferase - metabolism Glycine Isoenzymes - metabolism Kinetics Liver - enzymology Molecular Sequence Data Rats Structure-Activity Relationship Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!