Regulation of bombesin-stimulated inositol 1,4,5-trisphosphate generation in Swiss 3T3 fibroblasts by a guanine-nucleotide-binding protein

The stimulation of inositol phosphate generation by bombesin and GTP analogues was studied in Swiss 3T3 cells permeabilized by electroporation. Bombesin-stimulated inositol phosphate generation is potentiated by guanosine 5'-[gamma-thio]triphosphate (GTP[S]) and inhibited by guanosine 5'-[...

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Veröffentlicht in:	Biochemical journal 1990-06, Vol.268 (3), p.605-610
Hauptverfasser:	Plevin, R, Palmer, S, Gardner, S D, Wakelam, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bombesin Bombesin - pharmacology Cell Membrane Permeability Cells, Cultured Drug Synergism Fibroblasts - metabolism GTP-Binding Proteins - physiology guanine-nucleotide-binding protein Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Triphosphate - analogs & derivatives Guanosine Triphosphate - pharmacology inositol 1,4,5-trisphosphate Inositol 1,4,5-Trisphosphate - metabolism Mice Stimulation, Chemical Tetradecanoylphorbol Acetate - pharmacology Thionucleotides - pharmacology
Online-Zugang:	Volltext
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