Natural polyamines stimulate G-proteins

The natural polyamines spermine and spermidine, the biosynthetic precursor putrescine and their analogues cadaverine and tyramine stimulate the GTPase activity of purified GTP-binding proteins (Go/Gi) from calf brain reconstituted into phospholipid vesicles. The order of potency was spermine greater...

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Veröffentlicht in:	Biochemical journal 1992-03, Vol.282 (2), p.545-550
Hauptverfasser:	BUEB, J.-L, DA SILVA, A, MOUSLI, M, LANDRY, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Benzalkonium Compounds - pharmacology Binding and carrier proteins Biological and medical sciences brain Brain - metabolism Cattle Fundamental and applied biological sciences. Psychology GTP Phosphohydrolases - metabolism GTP-Binding Proteins - metabolism guanine nucleotide-binding protein Histamine Release - drug effects In Vitro Techniques Inositol Phosphates - biosynthesis Male Mast Cells - metabolism Muscle Contraction Peritoneal Cavity - cytology Pertussis Toxin polyamines Polyamines - pharmacology Proteins Rats Rats, Inbred Strains stimulation Trachea - cytology Trachea - drug effects Trachea - metabolism Trachea - physiology Virulence Factors, Bordetella - pharmacology
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