Mastoparan promotes exocytosis and increases intracellular cyclic AMP in human platelets : evidence for the existence of Ge-like mechanism of secretion

Recent studies have shown that mastoparan, an amphiphilic peptide derived from wasp venom, accelerates guanine nucleotide exchange and GTPase activity of purified GTP-binding proteins. In the present study we have examined the functional consequences of exposure of intact human platelets to mastopar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical journal 1992-01, Vol.281 (2), p.465-472
Hauptverfasser:	WHEELER-JONES, C. P. D, SAERMARK, T, KAKKAR, V. V, AUTHI, K. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Amino Acid Sequence Arachidonic Acids - metabolism Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Calcium - metabolism Cell physiology Cyclic AMP - metabolism Cytoplasmic Granules - metabolism Dose-Response Relationship, Drug Epoprostenol - pharmacology Exocytosis - drug effects Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism Guanosine Diphosphate - analogs & derivatives Guanosine Diphosphate - pharmacology Humans In Vitro Techniques Molecular and cellular biology Molecular Sequence Data Peptides Phosphatidylinositols - metabolism Platelet Activation Responses to growth factors, tumor promotors, other factors Saponins - pharmacology Staurosporine Thionucleotides - pharmacology Thrombin - metabolism Wasp Venoms - chemistry Wasp Venoms - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!