An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection
pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mou...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2024-08, Vol.68 (8), p.e0152023 |
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| container_issue | 8 |
| container_start_page | e0152023 |
| container_title | Antimicrobial agents and chemotherapy |
| container_volume | 68 |
| creator | Sun, Yan Zhang, Kaixi Delos Santos, May Pee, Carmen J E Yang, Yanmeng Kang, Meiqi Shin, Sung Jae Chan-Park, Mary B Pethe, Kevin |
| description | pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mouse model using only four injections of cyclophosphamide, which allows for sustained
lung burden for up to 16 days. This model proved effective for antibiotic efficacy evaluation, as demonstrated with imipenem or amikacin. |
| doi_str_mv | 10.1128/aac.01520-23 |
| format | Article |
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lung burden for up to 16 days. This model proved effective for antibiotic efficacy evaluation, as demonstrated with imipenem or amikacin.</description><identifier>ISSN: 0066-4804</identifier><identifier>ISSN: 1098-6596</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/aac.01520-23</identifier><identifier>PMID: 38990014</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Amikacin - pharmacology ; Amikacin - therapeutic use ; Animals ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antimicrobial Chemotherapy ; Cyclophosphamide - pharmacology ; Disease Models, Animal ; Experimental Therapeutics ; Female ; Imipenem - pharmacology ; Imipenem - therapeutic use ; Immunocompromised Host ; Lung - drug effects ; Lung - microbiology ; Mice ; Mycobacterium abscessus - drug effects ; Mycobacterium Infections, Nontuberculous - drug therapy ; Mycobacterium Infections, Nontuberculous - microbiology</subject><ispartof>Antimicrobial agents and chemotherapy, 2024-08, Vol.68 (8), p.e0152023</ispartof><rights>Copyright © 2024 American Society for Microbiology.</rights><rights>Copyright © 2024 American Society for Microbiology. 2024 American Society for Microbiology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a268t-d9d97aef87ddf99854c3e06fe6e4ab4a24cabd01a348dd668de66e8959325903</cites><orcidid>0000-0003-0916-8873 ; 0000-0003-0854-4582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304677/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304677/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38990014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wasserman, Sean</contributor><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Zhang, Kaixi</creatorcontrib><creatorcontrib>Delos Santos, May</creatorcontrib><creatorcontrib>Pee, Carmen J E</creatorcontrib><creatorcontrib>Yang, Yanmeng</creatorcontrib><creatorcontrib>Kang, Meiqi</creatorcontrib><creatorcontrib>Shin, Sung Jae</creatorcontrib><creatorcontrib>Chan-Park, Mary B</creatorcontrib><creatorcontrib>Pethe, Kevin</creatorcontrib><title>An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mouse model using only four injections of cyclophosphamide, which allows for sustained
lung burden for up to 16 days. This model proved effective for antibiotic efficacy evaluation, as demonstrated with imipenem or amikacin.</description><subject>Amikacin - pharmacology</subject><subject>Amikacin - therapeutic use</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antimicrobial Chemotherapy</subject><subject>Cyclophosphamide - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Experimental Therapeutics</subject><subject>Female</subject><subject>Imipenem - pharmacology</subject><subject>Imipenem - therapeutic use</subject><subject>Immunocompromised Host</subject><subject>Lung - drug effects</subject><subject>Lung - microbiology</subject><subject>Mice</subject><subject>Mycobacterium abscessus - drug effects</subject><subject>Mycobacterium Infections, Nontuberculous - drug therapy</subject><subject>Mycobacterium Infections, Nontuberculous - microbiology</subject><issn>0066-4804</issn><issn>1098-6596</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1PHSEUxUnTpj5td67NLGviWBgYBlbGmH4lNt24p3fgjg8zDCPMmDz_-tI-a-yim0tuzi8HDoeQY0bPGWvURwB7Tlnb0Lrhr8iGUa1q2Wr5mmwolbIWiooDcpjzHS17q-lbcsCV1pQysSE_L6cqzosP_hFdZXd2jPM25nkLwTusl4SwFCHENWOZDscqDtX3nY092AWTX0MFfbaY85qreR1DnCDtKj8NaBcfp3fkzQBjxvdP5xG5-fzp5uprff3jy7ery-saGqmW2mmnO8BBdc4NWqtWWI5UDihRQC-gERZ6RxlwoZyTUjmUEpVuNW9KJn5ELva289oHdBanJcFo5uRDeY6J4M2_yuS35jY-GMY4FbLrisOHJ4cU71fMiwm-5BpHmLCkN5x2qmO6U7KgZ3vUpphzwuH5HkbN71JMKcX8KcU0vOCnexxyaMxdXNNUfuJ_7MnLHM_GfxvjvwBtQpiQ</recordid><startdate>20240807</startdate><enddate>20240807</enddate><creator>Sun, Yan</creator><creator>Zhang, Kaixi</creator><creator>Delos Santos, May</creator><creator>Pee, Carmen J E</creator><creator>Yang, Yanmeng</creator><creator>Kang, Meiqi</creator><creator>Shin, Sung Jae</creator><creator>Chan-Park, Mary B</creator><creator>Pethe, Kevin</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0916-8873</orcidid><orcidid>https://orcid.org/0000-0003-0854-4582</orcidid></search><sort><creationdate>20240807</creationdate><title>An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection</title><author>Sun, Yan ; Zhang, Kaixi ; Delos Santos, May ; Pee, Carmen J E ; Yang, Yanmeng ; Kang, Meiqi ; Shin, Sung Jae ; Chan-Park, Mary B ; Pethe, Kevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a268t-d9d97aef87ddf99854c3e06fe6e4ab4a24cabd01a348dd668de66e8959325903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amikacin - pharmacology</topic><topic>Amikacin - therapeutic use</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antimicrobial Chemotherapy</topic><topic>Cyclophosphamide - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Experimental Therapeutics</topic><topic>Female</topic><topic>Imipenem - pharmacology</topic><topic>Imipenem - therapeutic use</topic><topic>Immunocompromised Host</topic><topic>Lung - drug effects</topic><topic>Lung - microbiology</topic><topic>Mice</topic><topic>Mycobacterium abscessus - drug effects</topic><topic>Mycobacterium Infections, Nontuberculous - drug therapy</topic><topic>Mycobacterium Infections, Nontuberculous - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Zhang, Kaixi</creatorcontrib><creatorcontrib>Delos Santos, May</creatorcontrib><creatorcontrib>Pee, Carmen J E</creatorcontrib><creatorcontrib>Yang, Yanmeng</creatorcontrib><creatorcontrib>Kang, Meiqi</creatorcontrib><creatorcontrib>Shin, Sung Jae</creatorcontrib><creatorcontrib>Chan-Park, Mary B</creatorcontrib><creatorcontrib>Pethe, Kevin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Yan</au><au>Zhang, Kaixi</au><au>Delos Santos, May</au><au>Pee, Carmen J E</au><au>Yang, Yanmeng</au><au>Kang, Meiqi</au><au>Shin, Sung Jae</au><au>Chan-Park, Mary B</au><au>Pethe, Kevin</au><au>Wasserman, Sean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2024-08-07</date><risdate>2024</risdate><volume>68</volume><issue>8</issue><spage>e0152023</spage><pages>e0152023-</pages><issn>0066-4804</issn><issn>1098-6596</issn><eissn>1098-6596</eissn><abstract>pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mouse model using only four injections of cyclophosphamide, which allows for sustained
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| ispartof | Antimicrobial agents and chemotherapy, 2024-08, Vol.68 (8), p.e0152023 |
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| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Amikacin - pharmacology Amikacin - therapeutic use Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antimicrobial Chemotherapy Cyclophosphamide - pharmacology Disease Models, Animal Experimental Therapeutics Female Imipenem - pharmacology Imipenem - therapeutic use Immunocompromised Host Lung - drug effects Lung - microbiology Mice Mycobacterium abscessus - drug effects Mycobacterium Infections, Nontuberculous - drug therapy Mycobacterium Infections, Nontuberculous - microbiology |
| title | An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection |
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