Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release

Inherited mutations in human beta-cardiac myosin (M2β) can lead to severe forms of heart failure. The E525K mutation in M2β is associated with dilated cardiomyopathy (DCM) and was found to stabilize the interacting heads motif (IHM) and autoinhibited super-relaxed (SRX) state in dimeric heavy meromy...

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Veröffentlicht in:	PNAS nexus 2024-08, Vol.3 (8), p.pgae279
Hauptverfasser:	Bodt, Skylar M L, Ge, Jinghua, Ma, Wen, Rasicci, David V, Desetty, Rohini, McCammon, J Andrew, Yengo, Christopher M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Biological, Health, and Medical Sciences Cardiomyopathy, Dilated Genetic aspects Molecular dynamics Muscle proteins Myosin Phosphates
Online-Zugang:	Volltext
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