Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation

The commitment of stem cells to differentiate into osteoblasts is a highly regulated and complex process that involves the coordination of extrinsic signals and intrinsic transcriptional machinery. While rodent osteoblastic differentiation has been extensively studied, research on human osteogenesis...

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Veröffentlicht in:	The Journal of biological chemistry 2024-08, Vol.300 (8), p.107494, Article 107494
Hauptverfasser:	Zhu, Dandan, Huang, Mo-Fan, Xu, An, Gao, Xueqin, Huang, Yu-Wen, Phan, Trinh T.T., Lu, Linchao, Chi, Ting-Yen, Dai, Yulin, Pang, Lon Kai, Gingold, Julian A., Tu, Jian, Huo, Zijun, Bazer, Danielle A., Shoemaker, Rachel, Wang, Jun, Ambrose, Catherine G., Shen, Jingnan, Kameoka, Jun, Zhao, Zhongming, Wang, Lisa L., Zhang, Yang, Zhao, Ruiying, Lee, Dung-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CCAAT-Enhancer-Binding Protein-delta - genetics CCAAT-Enhancer-Binding Protein-delta - metabolism Cell Differentiation ChIP-sequencing (ChIP-seq) Gene Expression Profiling Humans induced pluripotent stem cells (iPSCs) mesenchymal stem cells (MSCs) Mice osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis p38 MAPK Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Transcriptome
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