Associations of combined genetic and lifestyle risks with hypertension and home hypertension
No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In...
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| Veröffentlicht in: | Hypertension research 2024-08, Vol.47 (8), p.2064-2074 |
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| creator | Takase, Masato Hirata, Takumi Nakaya, Naoki Nakamura, Tomohiro Kogure, Mana Hatanaka, Rieko Nakaya, Kumi Chiba, Ippei Kanno, Ikumi Nochioka, Kotaro Tsuchiya, Naho Narita, Akira Metoki, Hirohito Satoh, Michihiro Obara, Taku Ishikuro, Mami Ohseto, Hisashi Uruno, Akira Kobayashi, Tomoko Kodama, Eiichi N. Hamanaka, Yohei Orui, Masatsugu Ogishima, Soichi Nagaie, Satoshi Fuse, Nobuo Sugawara, Junichi Kuriyama, Shinichi Tamiya, Gen Hozawa, Atsushi Yamamoto, Masayuki |
| description | No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (
n
= 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (
n
= 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34–2.80) and 2.15 (1.60–2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle. |
| doi_str_mv | 10.1038/s41440-024-01705-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11298407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3072000299</sourcerecordid><originalsourceid>FETCH-LOGICAL-c328t-b101124ac5e4208a6b540eb2963010e80e97a49c97ef9e47d8c134a0e2aacae43</originalsourceid><addsrcrecordid>eNp9kUtLAzEUhYMoWh9_wIXM0s3ozaOdZCUivkBwozshZNI7bXQmqclU6b83trXoxlUg9zvnPg4hxxTOKHB5ngQVAkpgogRawbCUW2RAuZClYFRskwEoOirViI_2yH5KrwBMDhXdJXtcKioq4APycplSsM70LvhUhKawoaudx3ExQY-9s4Xx46J1DaZ-0WIRXXpLxafrp8V0McPYo09ZuqSmocM_v4dkpzFtwqP1e0Ceb66fru7Kh8fb-6vLh9JyJvuypkApE8YOUTCQZlQPBWDN8uRAASWgqoxQVlXYKBTVWNq8pQFkxliDgh-Qi5XvbF53OLbo-2haPYuuM3Ghg3H6b8W7qZ6ED53bKimgyg6na4cY3ud5V925ZLFtjccwT5pDxSDfT6mMshVqY0gpYrPpQ0F_56JXueici17momUWnfyecCP5CSIDfAWkXPITjPo1zKPPV_vP9gsD-ptO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3072000299</pqid></control><display><type>article</type><title>Associations of combined genetic and lifestyle risks with hypertension and home hypertension</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Takase, Masato ; Hirata, Takumi ; Nakaya, Naoki ; Nakamura, Tomohiro ; Kogure, Mana ; Hatanaka, Rieko ; Nakaya, Kumi ; Chiba, Ippei ; Kanno, Ikumi ; Nochioka, Kotaro ; Tsuchiya, Naho ; Narita, Akira ; Metoki, Hirohito ; Satoh, Michihiro ; Obara, Taku ; Ishikuro, Mami ; Ohseto, Hisashi ; Uruno, Akira ; Kobayashi, Tomoko ; Kodama, Eiichi N. ; Hamanaka, Yohei ; Orui, Masatsugu ; Ogishima, Soichi ; Nagaie, Satoshi ; Fuse, Nobuo ; Sugawara, Junichi ; Kuriyama, Shinichi ; Tamiya, Gen ; Hozawa, Atsushi ; Yamamoto, Masayuki</creator><creatorcontrib>Takase, Masato ; Hirata, Takumi ; Nakaya, Naoki ; Nakamura, Tomohiro ; Kogure, Mana ; Hatanaka, Rieko ; Nakaya, Kumi ; Chiba, Ippei ; Kanno, Ikumi ; Nochioka, Kotaro ; Tsuchiya, Naho ; Narita, Akira ; Metoki, Hirohito ; Satoh, Michihiro ; Obara, Taku ; Ishikuro, Mami ; Ohseto, Hisashi ; Uruno, Akira ; Kobayashi, Tomoko ; Kodama, Eiichi N. ; Hamanaka, Yohei ; Orui, Masatsugu ; Ogishima, Soichi ; Nagaie, Satoshi ; Fuse, Nobuo ; Sugawara, Junichi ; Kuriyama, Shinichi ; Tamiya, Gen ; Hozawa, Atsushi ; Yamamoto, Masayuki ; ToMMo investigators ; the ToMMo investigators</creatorcontrib><description>No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (
n
= 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (
n
= 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34–2.80) and 2.15 (1.60–2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.</description><identifier>ISSN: 0916-9636</identifier><identifier>ISSN: 1348-4214</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-024-01705-8</identifier><identifier>PMID: 38914703</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Adult ; Aged ; Alcohol Drinking - genetics ; Blood Pressure - genetics ; Body Mass Index ; Cross-Sectional Studies ; Exercise ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Geriatrics/Gerontology ; Health Promotion and Disease Prevention ; Humans ; Hypertension - genetics ; Internal Medicine ; Japan - epidemiology ; Life Style ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multifactorial Inheritance ; Obstetrics/Perinatology/Midwifery ; Public Health ; Risk Factors</subject><ispartof>Hypertension research, 2024-08, Vol.47 (8), p.2064-2074</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c328t-b101124ac5e4208a6b540eb2963010e80e97a49c97ef9e47d8c134a0e2aacae43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38914703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takase, Masato</creatorcontrib><creatorcontrib>Hirata, Takumi</creatorcontrib><creatorcontrib>Nakaya, Naoki</creatorcontrib><creatorcontrib>Nakamura, Tomohiro</creatorcontrib><creatorcontrib>Kogure, Mana</creatorcontrib><creatorcontrib>Hatanaka, Rieko</creatorcontrib><creatorcontrib>Nakaya, Kumi</creatorcontrib><creatorcontrib>Chiba, Ippei</creatorcontrib><creatorcontrib>Kanno, Ikumi</creatorcontrib><creatorcontrib>Nochioka, Kotaro</creatorcontrib><creatorcontrib>Tsuchiya, Naho</creatorcontrib><creatorcontrib>Narita, Akira</creatorcontrib><creatorcontrib>Metoki, Hirohito</creatorcontrib><creatorcontrib>Satoh, Michihiro</creatorcontrib><creatorcontrib>Obara, Taku</creatorcontrib><creatorcontrib>Ishikuro, Mami</creatorcontrib><creatorcontrib>Ohseto, Hisashi</creatorcontrib><creatorcontrib>Uruno, Akira</creatorcontrib><creatorcontrib>Kobayashi, Tomoko</creatorcontrib><creatorcontrib>Kodama, Eiichi N.</creatorcontrib><creatorcontrib>Hamanaka, Yohei</creatorcontrib><creatorcontrib>Orui, Masatsugu</creatorcontrib><creatorcontrib>Ogishima, Soichi</creatorcontrib><creatorcontrib>Nagaie, Satoshi</creatorcontrib><creatorcontrib>Fuse, Nobuo</creatorcontrib><creatorcontrib>Sugawara, Junichi</creatorcontrib><creatorcontrib>Kuriyama, Shinichi</creatorcontrib><creatorcontrib>Tamiya, Gen</creatorcontrib><creatorcontrib>Hozawa, Atsushi</creatorcontrib><creatorcontrib>Yamamoto, Masayuki</creatorcontrib><creatorcontrib>ToMMo investigators</creatorcontrib><creatorcontrib>the ToMMo investigators</creatorcontrib><title>Associations of combined genetic and lifestyle risks with hypertension and home hypertension</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><addtitle>Hypertens Res</addtitle><description>No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (
n
= 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (
n
= 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34–2.80) and 2.15 (1.60–2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - genetics</subject><subject>Blood Pressure - genetics</subject><subject>Body Mass Index</subject><subject>Cross-Sectional Studies</subject><subject>Exercise</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Geriatrics/Gerontology</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Internal Medicine</subject><subject>Japan - epidemiology</subject><subject>Life Style</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multifactorial Inheritance</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Public Health</subject><subject>Risk Factors</subject><issn>0916-9636</issn><issn>1348-4214</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUtLAzEUhYMoWh9_wIXM0s3ozaOdZCUivkBwozshZNI7bXQmqclU6b83trXoxlUg9zvnPg4hxxTOKHB5ngQVAkpgogRawbCUW2RAuZClYFRskwEoOirViI_2yH5KrwBMDhXdJXtcKioq4APycplSsM70LvhUhKawoaudx3ExQY-9s4Xx46J1DaZ-0WIRXXpLxafrp8V0McPYo09ZuqSmocM_v4dkpzFtwqP1e0Ceb66fru7Kh8fb-6vLh9JyJvuypkApE8YOUTCQZlQPBWDN8uRAASWgqoxQVlXYKBTVWNq8pQFkxliDgh-Qi5XvbF53OLbo-2haPYuuM3Ghg3H6b8W7qZ6ED53bKimgyg6na4cY3ud5V925ZLFtjccwT5pDxSDfT6mMshVqY0gpYrPpQ0F_56JXueici17momUWnfyecCP5CSIDfAWkXPITjPo1zKPPV_vP9gsD-ptO</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Takase, Masato</creator><creator>Hirata, Takumi</creator><creator>Nakaya, Naoki</creator><creator>Nakamura, Tomohiro</creator><creator>Kogure, Mana</creator><creator>Hatanaka, Rieko</creator><creator>Nakaya, Kumi</creator><creator>Chiba, Ippei</creator><creator>Kanno, Ikumi</creator><creator>Nochioka, Kotaro</creator><creator>Tsuchiya, Naho</creator><creator>Narita, Akira</creator><creator>Metoki, Hirohito</creator><creator>Satoh, Michihiro</creator><creator>Obara, Taku</creator><creator>Ishikuro, Mami</creator><creator>Ohseto, Hisashi</creator><creator>Uruno, Akira</creator><creator>Kobayashi, Tomoko</creator><creator>Kodama, Eiichi N.</creator><creator>Hamanaka, Yohei</creator><creator>Orui, Masatsugu</creator><creator>Ogishima, Soichi</creator><creator>Nagaie, Satoshi</creator><creator>Fuse, Nobuo</creator><creator>Sugawara, Junichi</creator><creator>Kuriyama, Shinichi</creator><creator>Tamiya, Gen</creator><creator>Hozawa, Atsushi</creator><creator>Yamamoto, Masayuki</creator><general>Springer Nature Singapore</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240801</creationdate><title>Associations of combined genetic and lifestyle risks with hypertension and home hypertension</title><author>Takase, Masato ; Hirata, Takumi ; Nakaya, Naoki ; Nakamura, Tomohiro ; Kogure, Mana ; Hatanaka, Rieko ; Nakaya, Kumi ; Chiba, Ippei ; Kanno, Ikumi ; Nochioka, Kotaro ; Tsuchiya, Naho ; Narita, Akira ; Metoki, Hirohito ; Satoh, Michihiro ; Obara, Taku ; Ishikuro, Mami ; Ohseto, Hisashi ; Uruno, Akira ; Kobayashi, Tomoko ; Kodama, Eiichi N. ; Hamanaka, Yohei ; Orui, Masatsugu ; Ogishima, Soichi ; Nagaie, Satoshi ; Fuse, Nobuo ; Sugawara, Junichi ; Kuriyama, Shinichi ; Tamiya, Gen ; Hozawa, Atsushi ; Yamamoto, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-b101124ac5e4208a6b540eb2963010e80e97a49c97ef9e47d8c134a0e2aacae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking - 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We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (
n
= 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (
n
= 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34–2.80) and 2.15 (1.60–2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38914703</pmid><doi>10.1038/s41440-024-01705-8</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-9636 |
| ispartof | Hypertension research, 2024-08, Vol.47 (8), p.2064-2074 |
| issn | 0916-9636 1348-4214 1348-4214 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Alcohol Drinking - genetics Blood Pressure - genetics Body Mass Index Cross-Sectional Studies Exercise Female Genetic Predisposition to Disease Genome-Wide Association Study Geriatrics/Gerontology Health Promotion and Disease Prevention Humans Hypertension - genetics Internal Medicine Japan - epidemiology Life Style Male Medicine Medicine & Public Health Middle Aged Multifactorial Inheritance Obstetrics/Perinatology/Midwifery Public Health Risk Factors |
| title | Associations of combined genetic and lifestyle risks with hypertension and home hypertension |
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