Thyroid Nodules and Thyroid Cancer
A review of clinical and laboratory features of thyroid cancer, designed to help in a more precise selection of patients for operation, showed that factors contributing to a high index of suspicion of cancer include previous exposure to low doses of radiation, the presence of a firm, solitary thyroi...
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| Veröffentlicht in: | The Western journal of medicine 1974-11, Vol.121 (5), p.359-365 |
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| container_title | The Western journal of medicine |
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| creator | Greenspan, F S |
| description | A review of clinical and laboratory features of thyroid cancer, designed to help in a more precise selection of patients for operation, showed that factors contributing to a high index of suspicion of cancer include previous exposure to low doses of radiation, the presence of a firm, solitary thyroid nodule clearly different from the rest of the gland, a young patient, nodules that are “cold” on scan with radioiodine, and nodules that fail to regress after an adequate trial of thyroxine therapy. Factors contributing to a low index of suspicion of thyroid cancer include soft or cystic lesions, multinodular goiters, nodules that are “hot” on 131 I scan, and those that regress during thyroxine treatment. When these factors are used to select patients for surgical operation, about 30 percent are found to have thyroid cancer. Until more precise methods for preoperative diagnosis are established, it is suggested that this type of clinical selection may be very helpful in the management of patients with thyroid nodules or nontoxic goiter. |
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Factors contributing to a low index of suspicion of thyroid cancer include soft or cystic lesions, multinodular goiters, nodules that are “hot” on 131 I scan, and those that regress during thyroxine treatment. When these factors are used to select patients for surgical operation, about 30 percent are found to have thyroid cancer. Until more precise methods for preoperative diagnosis are established, it is suggested that this type of clinical selection may be very helpful in the management of patients with thyroid nodules or nontoxic goiter.</description><identifier>ISSN: 0093-0415</identifier><identifier>EISSN: 1476-2978</identifier><identifier>PMID: 4617969</identifier><identifier>CODEN: WJMDA2</identifier><language>eng</language><publisher>United States: BMJ Publishing Group LTD</publisher><subject>Adolescent ; Adult ; Aged ; Diagnosis, Differential ; Female ; Goiter - diagnosis ; Goiter - etiology ; Humans ; Iodine Radioisotopes ; Male ; Middle Aged ; Neoplasms, Radiation-Induced ; Radionuclide Imaging ; Thyroid Diseases - diagnosis ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - etiology ; Thyroxine - therapeutic use</subject><ispartof>The Western journal of medicine, 1974-11, Vol.121 (5), p.359-365</ispartof><rights>Copyright BMJ Publishing Group LTD Nov 1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129605/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129605/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4617969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greenspan, F S</creatorcontrib><title>Thyroid Nodules and Thyroid Cancer</title><title>The Western journal of medicine</title><addtitle>West J Med</addtitle><description>A review of clinical and laboratory features of thyroid cancer, designed to help in a more precise selection of patients for operation, showed that factors contributing to a high index of suspicion of cancer include previous exposure to low doses of radiation, the presence of a firm, solitary thyroid nodule clearly different from the rest of the gland, a young patient, nodules that are “cold” on scan with radioiodine, and nodules that fail to regress after an adequate trial of thyroxine therapy. Factors contributing to a low index of suspicion of thyroid cancer include soft or cystic lesions, multinodular goiters, nodules that are “hot” on 131 I scan, and those that regress during thyroxine treatment. When these factors are used to select patients for surgical operation, about 30 percent are found to have thyroid cancer. Until more precise methods for preoperative diagnosis are established, it is suggested that this type of clinical selection may be very helpful in the management of patients with thyroid nodules or nontoxic goiter.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Goiter - diagnosis</subject><subject>Goiter - etiology</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms, Radiation-Induced</subject><subject>Radionuclide Imaging</subject><subject>Thyroid Diseases - diagnosis</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - etiology</subject><subject>Thyroxine - therapeutic use</subject><issn>0093-0415</issn><issn>1476-2978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkNtKw0AQhhdRaq0-glD0OrCH2dONIMG2Qqmg9XC3bHY3NrVN6iYR-_YGWoteDcz3883wH6E-ASkSqqU6Rn2MNUswEH6Kzup6iTEGTnQP9UAQqYXuo6v5Yhurwg9nlW9XoR7a0g9_d6ktXYjn6CS3qzpc7OcAPY_u5ukkmT6M79PbaVIwKpuEk1wBdk4SFYBZTjPJIFAKAVSOcSAgfCYyRcERZ73IhcocJYxrTzBzwAboZufdtNk6eBfKJtqV2cRibePWVLYw_0lZLMx79WUIoVpg3gmu94JYfbahbsyyamPZ_WyIlKCgKwJ3qcu_Zw7-fSUdT3a8qJvwfcA2fhghmeRm9pIaeEwnb69sZJ7YDzV1a9s</recordid><startdate>197411</startdate><enddate>197411</enddate><creator>Greenspan, F S</creator><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>197411</creationdate><title>Thyroid Nodules and Thyroid Cancer</title><author>Greenspan, F S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i327t-51f840cc718e43a52b734e224e48f00e146db6b824c1cad6f68bc21359d103c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Goiter - diagnosis</topic><topic>Goiter - etiology</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms, Radiation-Induced</topic><topic>Radionuclide Imaging</topic><topic>Thyroid Diseases - diagnosis</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - etiology</topic><topic>Thyroxine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenspan, F S</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Western journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenspan, F S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid Nodules and Thyroid Cancer</atitle><jtitle>The Western journal of medicine</jtitle><addtitle>West J Med</addtitle><date>1974-11</date><risdate>1974</risdate><volume>121</volume><issue>5</issue><spage>359</spage><epage>365</epage><pages>359-365</pages><issn>0093-0415</issn><eissn>1476-2978</eissn><coden>WJMDA2</coden><abstract>A review of clinical and laboratory features of thyroid cancer, designed to help in a more precise selection of patients for operation, showed that factors contributing to a high index of suspicion of cancer include previous exposure to low doses of radiation, the presence of a firm, solitary thyroid nodule clearly different from the rest of the gland, a young patient, nodules that are “cold” on scan with radioiodine, and nodules that fail to regress after an adequate trial of thyroxine therapy. Factors contributing to a low index of suspicion of thyroid cancer include soft or cystic lesions, multinodular goiters, nodules that are “hot” on 131 I scan, and those that regress during thyroxine treatment. When these factors are used to select patients for surgical operation, about 30 percent are found to have thyroid cancer. Until more precise methods for preoperative diagnosis are established, it is suggested that this type of clinical selection may be very helpful in the management of patients with thyroid nodules or nontoxic goiter.</abstract><cop>United States</cop><pub>BMJ Publishing Group LTD</pub><pmid>4617969</pmid><tpages>7</tpages></addata></record> |
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| ispartof | The Western journal of medicine, 1974-11, Vol.121 (5), p.359-365 |
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| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Adolescent Adult Aged Diagnosis, Differential Female Goiter - diagnosis Goiter - etiology Humans Iodine Radioisotopes Male Middle Aged Neoplasms, Radiation-Induced Radionuclide Imaging Thyroid Diseases - diagnosis Thyroid Neoplasms - diagnosis Thyroid Neoplasms - etiology Thyroxine - therapeutic use |
| title | Thyroid Nodules and Thyroid Cancer |
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