Genomic profiling of a multi-lineage and multi-passage patient-derived xenograft biobank reflects heterogeneity of ovarian cancer

Ovarian cancer (OC) manifests as a complex disease characterized by inter- and intra-patient heterogeneity. Despite enhanced biological and genetic insights, OC remains a recalcitrant malignancy with minimal survival improvement. Based on multi-site sampling and a multi-lineage patient-derived xenog...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell reports. Medicine 2024-07, Vol.5 (7), p.101631, Article 101631
Hauptverfasser:	Qin, Tianyu, Hu, Zhe, Zhang, Li, Lu, Funian, Xiao, Rourou, Liu, Yiting, Fan, Junpeng, Guo, Ensong, Yang, Bin, Fu, Yu, Zhuang, Xucui, Kang, Xiaoyan, Wu, Zimeng, Fang, Zixuan, Cui, Yaoyuan, Hu, Xingyuan, Yin, Jingjing, Yan, Miao, Li, Fuxia, Song, Kun, Chen, Gang, Sun, Chaoyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biobank Biological Specimen Banks Cell Lineage - genetics clonal evolution DNA Damage - genetics Drug Resistance, Neoplasm - genetics Female Genetic Heterogeneity genomic charaterization Genomics - methods Humans Interferons - genetics Interferons - metabolism Mice ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology patient-derived xenograft preclinical cancer model tumor heterogeneity Wnt Signaling Pathway - genetics Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!