Nonclassical Zwitterions as a Design Principle to Reduce Lipophilicity without Impacting Permeability

The ionization of bioactive molecules impacts many ADME-relevant physicochemical properties, in particular, solubility, lipophilicity, and permeability. Ampholytes contain both acidic and basic groups and are distinguished as ordinary ampholytes and zwitterions. An influential review states that zwi...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-06, Vol.67 (11), p.9485-9494
Hauptverfasser:	Möbitz, Henrik, Dittrich, Birger, Rodde, Stephane, Strang, Ross
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Humans Hydrogen Bonding Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Permeability Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Solubility
Online-Zugang:	Volltext
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