Protective effects of exogenous secretin on ceruletide-induced acute pancreatitis in the rat

Unconscious rats given intravenous ceruletide (diethylamine salt of the decapeptide caerulein) in large pharmacologic doses consistently developed moderate acute pancreatitis by 3 h and florid pancreatitis by 6 h. Biochemical serum markers of acute pancreatitis tended to parallel the severity of the...

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Veröffentlicht in:	The Journal of clinical investigation 1983-09, Vol.72 (3), p.1081-1092
Hauptverfasser:	RENNER, I. G, WISNER, J. R. JR, RINDERKNECHT, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Amylases - blood Animals Biological and medical sciences Ceruletide - administration & dosage Edema - chemically induced Edema - drug therapy Edema - pathology Fat Necrosis - pathology Gastroenterology. Liver. Pancreas. Abdomen Lipase - blood Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Malformations Medical sciences Pancreas - ultrastructure Pancreatitis - chemically induced Pancreatitis - drug therapy Pancreatitis - pathology Rats Rats, Inbred Strains Secretin - therapeutic use Trypsinogen - blood
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