Interleukin 13 Promotes Maturation and Proliferation in Metaplastic Gastroids

Type 2 innate lymphoid cells (ILC2s) and interleukin-13 (IL-13) promote the onset of spasmolytic polypeptide-expressing metaplasia (SPEM) cells. However, little is known about molecular effects of IL-13 in SPEM cells. We now sought to establish a reliable organoid model, Meta1 gastroids, to model SP...

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Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2024-01, Vol.18 (3), p.101366, Article 101366
Hauptverfasser:	Contreras-Panta, Ela W., Lee, Su-Hyung, Won, Yoonkyung, Norlander, Allison E., Simmons, Alan J., Peebles, R. Stokes, Lau, Ken S., Choi, Eunyoung, Goldenring, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AQP5 CD44v9 Cell Proliferation - drug effects Gastric Mucosa - cytology Gastric Mucosa - immunology Gastric Mucosa - metabolism Gastric Mucosa - pathology Humans ILC2 Immunity, Innate Intercellular Signaling Peptides and Proteins Interleukin-13 Interleukin-13 - metabolism Interleukin-13 - pharmacology Lymphocytes - drug effects Lymphocytes - immunology Lymphocytes - metabolism Maturation Metaplasia Mice Mice, Transgenic Organoids - metabolism Original Research Proliferation Single-Cell Analysis SPEM STAT6 STAT6 Transcription Factor - metabolism Stomach - cytology Stomach - pathology
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