A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements

A covalent adduct of DFOB and DOTA separated by a l -lysine residue (DFOB- l -Lys- N 6 -DOTA) exhibited remarkable regioselective metal binding, with { 1 H}- 13 C NMR spectral shifts supporting Zr( iv ) coordinating to the DFOB unit, and Lu( iii ) coordinating to the DOTA unit. This first-in-class,...

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Veröffentlicht in:Chemical science (Cambridge) 2024-07, Vol.15 (3), p.11748-1176
Hauptverfasser: Wood, James L, Ghosh, Saikat, Houston, Zachary H, Fletcher, Nicholas L, Humphries, James, Mardon, Karine, Akhter, Dewan T, Tieu, William, Ivashkevich, Alesia, Wheatcroft, Michael P, Thurecht, Kristofer J, Codd, Rachel
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Sprache:eng
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