Targeting sphingolipid metabolism in chronic lymphocytic leukemia

Elevated levels of circulating C16:0 glucosylceramides (GluCer) and increased mRNA expression of UDP-glucose ceramide glycosyltransferase ( UGCG ), the enzyme responsible for converting ceramides (Cer) to GluCer, represent unfavorable prognostic markers in chronic lymphocytic leukemia (CLL) patients...

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Veröffentlicht in:	Clinical and experimental medicine 2024-07, Vol.24 (1), p.174, Article 174
Hauptverfasser:	Nguyen Van Long, Flora, Le, Trang, Caron, Patrick, Valcourt-Gendron, Délya, Sergerie, Roxanne, Laverdière, Isabelle, Vanura, Katrina, Guillemette, Chantal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cell culture Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cell viability Ceramide Chronic lymphocytic leukemia Drug development Gene expression Glucosylceramides - metabolism Glucosyltransferases - antagonists & inhibitors Glucosyltransferases - genetics Glucosyltransferases - metabolism Glycosyltransferase Hematology Humans Internal Medicine Intracellular Intracellular levels Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lipid metabolism Lymphocytes B Mass spectroscopy Medicine Medicine & Public Health Metabolism Oncology Piperidines - pharmacology Pyrazoles - pharmacology Pyrimidines - pharmacology Sphingolipids Sphingolipids - metabolism
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