E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network

Various lines of investigation support a signaling interphase shared by receptor tyrosine kinases and the DNA damage response. However, the underlying network nodes and their contribution to the maintenance of DNA integrity remain unknown. We explored MET-related metabolic pathways in which interrup...

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Veröffentlicht in:	Cancer research communications 2024-07, Vol.4 (7), p.1863-1880
Hauptverfasser:	Poliaková Turan, Michaela, Riedo, Rahel, Medo, Matúš, Pozzato, Chiara, Friese-Hamim, Manja, Koch, Jonas P, Coggins, Si'Ana A, Li, Qun, Kim, Baek, Albers, Joachim, Aebersold, Daniel M, Zamboni, Nicola, Zimmer, Yitzhak, Medová, Michaela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor DNA Damage - drug effects DNA Repair - drug effects E2F1 Transcription Factor - genetics E2F1 Transcription Factor - metabolism Humans Mice Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Purines - biosynthesis Purines - metabolism Signal Transduction - drug effects Xenograft Model Antitumor Assays
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