Relation of cumulative exposure to inorganic lead and neuropsychological test performance
OBJECTIVES--To determine if measures reflecting chronic occupational lead exposure are associated with performance on neuropsychological tests. METHOD--467 Canadian male lead smelter workers (mean (SD) age 43.4 (11.00) years, education 9.8 (3.18) years, years of employment 17.7 (7.43), and current b...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 1996-07, Vol.53 (7), p.472-477 |
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| creator | Lindgren, K N Masten, V L Ford, D P Bleecker, M L |
| description | OBJECTIVES--To determine if measures reflecting chronic occupational lead exposure are associated with performance on neuropsychological tests. METHOD--467 Canadian male lead smelter workers (mean (SD) age 43.4 (11.00) years, education 9.8 (3.18) years, years of employment 17.7 (7.43), and current blood lead concentration (B-Pb) 27.5 (8.4) micrograms dl-1) were given a neuropsychological screening battery. Time weighted average (TWA) and time integrated blood levels (IBL) were developed from B-Pb records obtained through regular medical monitoring (mean (range) TWA 40.1 (4.0-66.4) micrograms dl-1, mean IBL 765.2 (0.6-1625.7) micrograms-y dl-1). 14 neuropsychological variables were included in three multivariate analyses of covariance, with each exposure variable as the grouping variable (high, medium, and low) and age, education, score on a measure of depressive symptoms, and self reported alcohol use as the covariates. Groups did not differ in history of neurological conditions. RESULTS--Neither the B-Pb, TWA, nor IBL was significant by multivariate analyses of covariance (MANCOVA). When years of employment, a suppressor variable, was included as a covariate, IBL exposure groups differed significantly on digit symbol, logical memory, Purdue dominant hand, and trails A and B. CONCLUSIONS--A dose-effect relation was found between cumulative exposure (IBL) and neuropsychological performance at a time when current B-Pb concentrations were low and showed no association with performance. |
| doi_str_mv | 10.1136/oem.53.7.472 |
| format | Article |
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METHOD--467 Canadian male lead smelter workers (mean (SD) age 43.4 (11.00) years, education 9.8 (3.18) years, years of employment 17.7 (7.43), and current blood lead concentration (B-Pb) 27.5 (8.4) micrograms dl-1) were given a neuropsychological screening battery. Time weighted average (TWA) and time integrated blood levels (IBL) were developed from B-Pb records obtained through regular medical monitoring (mean (range) TWA 40.1 (4.0-66.4) micrograms dl-1, mean IBL 765.2 (0.6-1625.7) micrograms-y dl-1). 14 neuropsychological variables were included in three multivariate analyses of covariance, with each exposure variable as the grouping variable (high, medium, and low) and age, education, score on a measure of depressive symptoms, and self reported alcohol use as the covariates. Groups did not differ in history of neurological conditions. RESULTS--Neither the B-Pb, TWA, nor IBL was significant by multivariate analyses of covariance (MANCOVA). When years of employment, a suppressor variable, was included as a covariate, IBL exposure groups differed significantly on digit symbol, logical memory, Purdue dominant hand, and trails A and B. CONCLUSIONS--A dose-effect relation was found between cumulative exposure (IBL) and neuropsychological performance at a time when current B-Pb concentrations were low and showed no association with performance.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.53.7.472</identifier><identifier>PMID: 8704872</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adult ; Age ; Alcoholic beverages ; Alcohols ; Biological and medical sciences ; Blood levels ; Chemical and industrial products toxicology. Toxic occupational diseases ; Confounding Factors (Epidemiology) ; Depressive disorders ; Dose-response effects ; Education ; Employment ; Exposure ; Humans ; Lead ; Lead - adverse effects ; Lead - blood ; Male ; Medical sciences ; Memory ; Metallurgy ; Metals and various inorganic compounds ; Middle Aged ; Multivariate Analysis ; Neuropsychological Tests ; Neuropsychology ; Occupational Exposure - adverse effects ; Smelters ; Time Factors ; Toxicology ; Weighted averages</subject><ispartof>Occupational and environmental medicine (London, England), 1996-07, Vol.53 (7), p.472-477</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jul 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b559t-e8126433d183307548cc5defce4c5147e2d0d2960f5311ae8bf77ec3fca51f113</citedby><cites>FETCH-LOGICAL-b559t-e8126433d183307548cc5defce4c5147e2d0d2960f5311ae8bf77ec3fca51f113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27730578$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27730578$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3132447$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8704872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindgren, K N</creatorcontrib><creatorcontrib>Masten, V L</creatorcontrib><creatorcontrib>Ford, D P</creatorcontrib><creatorcontrib>Bleecker, M L</creatorcontrib><title>Relation of cumulative exposure to inorganic lead and neuropsychological test performance</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>OBJECTIVES--To determine if measures reflecting chronic occupational lead exposure are associated with performance on neuropsychological tests. METHOD--467 Canadian male lead smelter workers (mean (SD) age 43.4 (11.00) years, education 9.8 (3.18) years, years of employment 17.7 (7.43), and current blood lead concentration (B-Pb) 27.5 (8.4) micrograms dl-1) were given a neuropsychological screening battery. Time weighted average (TWA) and time integrated blood levels (IBL) were developed from B-Pb records obtained through regular medical monitoring (mean (range) TWA 40.1 (4.0-66.4) micrograms dl-1, mean IBL 765.2 (0.6-1625.7) micrograms-y dl-1). 14 neuropsychological variables were included in three multivariate analyses of covariance, with each exposure variable as the grouping variable (high, medium, and low) and age, education, score on a measure of depressive symptoms, and self reported alcohol use as the covariates. Groups did not differ in history of neurological conditions. RESULTS--Neither the B-Pb, TWA, nor IBL was significant by multivariate analyses of covariance (MANCOVA). When years of employment, a suppressor variable, was included as a covariate, IBL exposure groups differed significantly on digit symbol, logical memory, Purdue dominant hand, and trails A and B. CONCLUSIONS--A dose-effect relation was found between cumulative exposure (IBL) and neuropsychological performance at a time when current B-Pb concentrations were low and showed no association with performance.</description><subject>Adult</subject><subject>Age</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Biological and medical sciences</subject><subject>Blood levels</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Depressive disorders</subject><subject>Dose-response effects</subject><subject>Education</subject><subject>Employment</subject><subject>Exposure</subject><subject>Humans</subject><subject>Lead</subject><subject>Lead - adverse effects</subject><subject>Lead - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Metallurgy</subject><subject>Metals and various inorganic compounds</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Occupational Exposure - adverse effects</subject><subject>Smelters</subject><subject>Time Factors</subject><subject>Toxicology</subject><subject>Weighted averages</subject><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1v1DAQxSMEKm3hxhXJEgguZPHYcSZ7QYLlU5QiIT4EF8vrTLZekji1k6r973G1q_Bx4OSx3k9P8-Zl2T3gCwBZPvXULZRc4KJAcSM7hAJ5jktR3kyzVJBzBLidHcW45RwkSnGQHVTIiwrFYfb9E7VmdL5nvmF26qbr3wUxuhx8nAKx0TPX-7AxvbOsJVMz09espyn4IV7ZM9_6jbOmZSPFkQ0UGh8601u6k91qTBvp7v49zr68fvV59TY_-fjm3er5Sb5WajnmVIEoCylrqKTkqIrKWlVTY6mwKmUhUfNaLEveKAlgqFo3iGRlY42CJh3gOHu28x2mdUe1pX4MptVDcJ0JV9obp_9WenemN_5CA4hKQZkMHu0Ngj-fUgrduWipbU1PfooaFFYVSJ7AB_-AWz-FPoXTgJhiLAVXiXqyo2zwMQZq5lWA6-vCdCpMK6lRp8ISfv_P9Wd431DSH-51E9OZm5Bu6-KMSZCiKPC3zTaOPsyyQJQ87Z_0fKe7ONLlrJvwU5coUenTrysNP_D0w4uX3_T7xD_e8etu-_8AvwAJcMVE</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Lindgren, K N</creator><creator>Masten, V L</creator><creator>Ford, D P</creator><creator>Bleecker, M L</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7T2</scope><scope>7TK</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>19960701</creationdate><title>Relation of cumulative exposure to inorganic lead and neuropsychological test performance</title><author>Lindgren, K N ; Masten, V L ; Ford, D P ; Bleecker, M L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b559t-e8126433d183307548cc5defce4c5147e2d0d2960f5311ae8bf77ec3fca51f113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Age</topic><topic>Alcoholic beverages</topic><topic>Alcohols</topic><topic>Biological and medical sciences</topic><topic>Blood levels</topic><topic>Chemical and industrial products toxicology. 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METHOD--467 Canadian male lead smelter workers (mean (SD) age 43.4 (11.00) years, education 9.8 (3.18) years, years of employment 17.7 (7.43), and current blood lead concentration (B-Pb) 27.5 (8.4) micrograms dl-1) were given a neuropsychological screening battery. Time weighted average (TWA) and time integrated blood levels (IBL) were developed from B-Pb records obtained through regular medical monitoring (mean (range) TWA 40.1 (4.0-66.4) micrograms dl-1, mean IBL 765.2 (0.6-1625.7) micrograms-y dl-1). 14 neuropsychological variables were included in three multivariate analyses of covariance, with each exposure variable as the grouping variable (high, medium, and low) and age, education, score on a measure of depressive symptoms, and self reported alcohol use as the covariates. Groups did not differ in history of neurological conditions. RESULTS--Neither the B-Pb, TWA, nor IBL was significant by multivariate analyses of covariance (MANCOVA). When years of employment, a suppressor variable, was included as a covariate, IBL exposure groups differed significantly on digit symbol, logical memory, Purdue dominant hand, and trails A and B. CONCLUSIONS--A dose-effect relation was found between cumulative exposure (IBL) and neuropsychological performance at a time when current B-Pb concentrations were low and showed no association with performance.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>8704872</pmid><doi>10.1136/oem.53.7.472</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Occupational and environmental medicine (London, England), 1996-07, Vol.53 (7), p.472-477 |
| issn | 1351-0711 1470-7926 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1128516 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Age Alcoholic beverages Alcohols Biological and medical sciences Blood levels Chemical and industrial products toxicology. Toxic occupational diseases Confounding Factors (Epidemiology) Depressive disorders Dose-response effects Education Employment Exposure Humans Lead Lead - adverse effects Lead - blood Male Medical sciences Memory Metallurgy Metals and various inorganic compounds Middle Aged Multivariate Analysis Neuropsychological Tests Neuropsychology Occupational Exposure - adverse effects Smelters Time Factors Toxicology Weighted averages |
| title | Relation of cumulative exposure to inorganic lead and neuropsychological test performance |
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