Effect of subchronic in vivo exposure to nitrogen dioxide on lung tissue inflammation, airway microvascular leakage, and in vitro bronchial muscle responsiveness in rats

OBJECTIVES: In a previous study on bronchoalveolar lavage fluid from rats exposed in vivo for seven days to 10 ppm nitrogen dioxide (NO2), it has been shown that there is an influx of macrophages into the airways. The present study investigated the effect of seven day exposure to 10 ppm NO2, on: (a)...

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Veröffentlicht in:	Occupational and environmental medicine (London, England) England), 1996-06, Vol.53 (6), p.379-386
Hauptverfasser:	Chitano, P, Rado, V, Di Stefano, A, Papi, A, Boniotti, A, Zancuoghi, G, Boschetto, P, Romano, M, Salmona, M, Ciaccia, A, Fabbri, L M, Mapp, C E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Air Animals Biological and medical sciences Bronchi Bronchoconstriction - drug effects Capillary Permeability - drug effects Dioxides Electric fields Electric Stimulation Environmental pollutants toxicology Histology Inflammation Light microscopy Lung - drug effects Lung - pathology Lungs Medical sciences Muscle, Smooth - drug effects Nitrogen Nitrogen dioxide Nitrogen Dioxide - adverse effects Permeability Pneumonia - chemically induced Pulmonary alveoli Pulmonary Circulation - drug effects Rats Rats, Sprague-Dawley Serotonin - pharmacology Serotonin receptors Smooth muscle Toxicology
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