Knockdown of SDC-1 Gene Alleviates the Metabolic Pathway for the Development of MODS
This study aims to reveal the metabolic differences between SDC-1 knockout mice and wild-type mice and the metabolic differences caused by shock in SDC-1 knockout mice by integrating transcriptomics and metabolomics. A total of 1009 differential metabolites were differentially expressed based on unt...
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| Veröffentlicht in: | Molecular biotechnology 2024-08, Vol.66 (8), p.1961-1969 |
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| container_issue | 8 |
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| container_title | Molecular biotechnology |
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| creator | Xie, Jiangang Ma, Yuexiang Huang, Yang Wang, Qianmei Xu, Yunyun Zhang, Qi Yang, Jing Yin, Wen |
| description | This study aims to reveal the metabolic differences between SDC-1 knockout mice and wild-type mice and the metabolic differences caused by shock in SDC-1 knockout mice by integrating transcriptomics and metabolomics. A total of 1009 differential metabolites were differentially expressed based on untargeted metabolomics and high-resolution mass spectrometry detection techniques. According to Kyoto Encyclopedia of Genes and Genomes enrichment, SDC-1 knockout significantly altered fat digestion and absorption, GnRH signaling pathway, fructose and mannose metabolism, and some other amino-related metabolic pathways and significantly modulated positively regulated longevity regulatory pathways, longevity regulatory pathways-worm, nicotinamide and niacinamide metabolism, and vitamin digestion and absorption pathways after its shock. Our findings indicate that SDC-1 knockout may have potential therapeutic effects in hemorrhagic shock by increasing nicotinamide metabolism. |
| doi_str_mv | 10.1007/s12033-023-00809-9 |
| format | Article |
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A total of 1009 differential metabolites were differentially expressed based on untargeted metabolomics and high-resolution mass spectrometry detection techniques. According to Kyoto Encyclopedia of Genes and Genomes enrichment, SDC-1 knockout significantly altered fat digestion and absorption, GnRH signaling pathway, fructose and mannose metabolism, and some other amino-related metabolic pathways and significantly modulated positively regulated longevity regulatory pathways, longevity regulatory pathways-worm, nicotinamide and niacinamide metabolism, and vitamin digestion and absorption pathways after its shock. Our findings indicate that SDC-1 knockout may have potential therapeutic effects in hemorrhagic shock by increasing nicotinamide metabolism.</description><identifier>ISSN: 1073-6085</identifier><identifier>ISSN: 1559-0305</identifier><identifier>EISSN: 1559-0305</identifier><identifier>DOI: 10.1007/s12033-023-00809-9</identifier><identifier>PMID: 37515659</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Absorption ; Animals ; biochemical pathways ; Biochemistry ; Biological Techniques ; Biotechnology ; Cell Biology ; Chemistry ; Chemistry and Materials Science ; Chondroitin sulfate ; Digestion ; Encyclopedias ; Extracellular matrix ; Fat metabolism ; fructose ; Gene Knockdown Techniques ; Genes ; Genomes ; Gonadotropin-releasing hormone ; Hemorrhagic shock ; Heparan sulfate ; Homeostasis ; Human Genetics ; Hyaluronic acid ; Immune system ; Inflammation ; Laboratory animals ; lipid metabolism ; Longevity ; Male ; Mannose ; Mass spectrometry ; Mass spectroscopy ; Metabolic Networks and Pathways - genetics ; Metabolic pathways ; Metabolism ; Metabolites ; Metabolomics ; Metabolomics - methods ; Mice ; Mice, Knockout ; Mortality ; Multiple organ dysfunction syndrome ; Niacinamide - metabolism ; Nicotinamide ; Original Paper ; Principal components analysis ; Protein Science ; Quality control ; Reproducibility ; Scientific imaging ; Shock, Hemorrhagic - genetics ; Shock, Hemorrhagic - metabolism ; Shock, Hemorrhagic - therapy ; Signal transduction ; Syndecan-1 - genetics ; Syndecan-1 - metabolism ; therapeutics ; Transcriptomics ; Trauma</subject><ispartof>Molecular biotechnology, 2024-08, Vol.66 (8), p.1961-1969</ispartof><rights>The Author(s) 2023</rights><rights>2023. 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Our findings indicate that SDC-1 knockout may have potential therapeutic effects in hemorrhagic shock by increasing nicotinamide metabolism.</description><subject>Absorption</subject><subject>Animals</subject><subject>biochemical pathways</subject><subject>Biochemistry</subject><subject>Biological Techniques</subject><subject>Biotechnology</subject><subject>Cell Biology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chondroitin sulfate</subject><subject>Digestion</subject><subject>Encyclopedias</subject><subject>Extracellular matrix</subject><subject>Fat metabolism</subject><subject>fructose</subject><subject>Gene Knockdown Techniques</subject><subject>Genes</subject><subject>Genomes</subject><subject>Gonadotropin-releasing hormone</subject><subject>Hemorrhagic shock</subject><subject>Heparan sulfate</subject><subject>Homeostasis</subject><subject>Human Genetics</subject><subject>Hyaluronic acid</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>lipid metabolism</subject><subject>Longevity</subject><subject>Male</subject><subject>Mannose</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolic Networks and Pathways - genetics</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Metabolomics - methods</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mortality</subject><subject>Multiple organ dysfunction syndrome</subject><subject>Niacinamide - metabolism</subject><subject>Nicotinamide</subject><subject>Original Paper</subject><subject>Principal components analysis</subject><subject>Protein Science</subject><subject>Quality control</subject><subject>Reproducibility</subject><subject>Scientific imaging</subject><subject>Shock, Hemorrhagic - genetics</subject><subject>Shock, Hemorrhagic - metabolism</subject><subject>Shock, Hemorrhagic - therapy</subject><subject>Signal transduction</subject><subject>Syndecan-1 - genetics</subject><subject>Syndecan-1 - metabolism</subject><subject>therapeutics</subject><subject>Transcriptomics</subject><subject>Trauma</subject><issn>1073-6085</issn><issn>1559-0305</issn><issn>1559-0305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNqFkUtPGzEUhS1E1VDoH2CBRmLTzbTXr7G9qlDShqogkKBry5m5kwxMxsGeBPHvcRJKgUVZWLZ0Pp_7OIQcUvhKAdS3SBlwngNLBzSY3OyQPSqlyYGD3E1vUDwvQMsB-RTjDQCjUvCPZMCVpLKQZo9c_-58eVv5-y7zdXY1GuY0G2OH2Unb4qpxPcasn2F2jr2b-LYps0vXz-7dQ1b7sFFGuMLWL-bY9WuL84vR1QH5ULs24uene5_8-fnjenian12Mfw1PzvJSSNPnwlClmJZQiNTLpJAV1Ci0Y0KwotIVIgUmXF1y4dApowAE59ooVhW6ZIbvk-9b38VyMseqTC0E19pFaOYuPFjvGvta6ZqZnfqVpZRpaiRLDl-eHIK_W2Ls7byJJbat69Avo-VU8lS2UOJdNA0iBBdcFwk9foPe-GXo0iosBy2MUimJRLEtVQYfY8D6uXEKdh2w3QZsU8B2E7Bdj3z0cuTnL38TTQDfAjFJ3RTDv9r_sX0Eoj2tsQ</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Xie, Jiangang</creator><creator>Ma, Yuexiang</creator><creator>Huang, Yang</creator><creator>Wang, Qianmei</creator><creator>Xu, Yunyun</creator><creator>Zhang, Qi</creator><creator>Yang, Jing</creator><creator>Yin, Wen</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0004-6175-8752</orcidid></search><sort><creationdate>20240801</creationdate><title>Knockdown of SDC-1 Gene Alleviates the Metabolic Pathway for the Development of MODS</title><author>Xie, Jiangang ; 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| subjects | Absorption Animals biochemical pathways Biochemistry Biological Techniques Biotechnology Cell Biology Chemistry Chemistry and Materials Science Chondroitin sulfate Digestion Encyclopedias Extracellular matrix Fat metabolism fructose Gene Knockdown Techniques Genes Genomes Gonadotropin-releasing hormone Hemorrhagic shock Heparan sulfate Homeostasis Human Genetics Hyaluronic acid Immune system Inflammation Laboratory animals lipid metabolism Longevity Male Mannose Mass spectrometry Mass spectroscopy Metabolic Networks and Pathways - genetics Metabolic pathways Metabolism Metabolites Metabolomics Metabolomics - methods Mice Mice, Knockout Mortality Multiple organ dysfunction syndrome Niacinamide - metabolism Nicotinamide Original Paper Principal components analysis Protein Science Quality control Reproducibility Scientific imaging Shock, Hemorrhagic - genetics Shock, Hemorrhagic - metabolism Shock, Hemorrhagic - therapy Signal transduction Syndecan-1 - genetics Syndecan-1 - metabolism therapeutics Transcriptomics Trauma |
| title | Knockdown of SDC-1 Gene Alleviates the Metabolic Pathway for the Development of MODS |
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