The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective
Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological and pathophysiological processes in the body. Recently, a bidirectional relationship between circadian rhythms and several neurological diseases has been reported. Neurological diseases can lead to the disrup...
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| Veröffentlicht in: | Aging and disease 2024-08, Vol.15 (4), p.1565-1587 |
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| container_title | Aging and disease |
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| creator | Huang, Wanbin Zong, Jiabin Zhang, Yu Zhou, Yanjie Zhang, Lily Wang, Yajuan Shan, Zhengming Xie, Qingfang Li, Ming Pan, Songqing Xiao, Zheman |
| description | Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological and pathophysiological processes in the body. Recently, a bidirectional relationship between circadian rhythms and several neurological diseases has been reported. Neurological diseases can lead to the disruption of circadian homeostasis, thereby increasing disease severity. Therefore, optimizing the current treatments through circadian-based approaches, including adjusted dosing, changing lifestyle, and targeted interventions, offer a promising opportunity for better clinical outcomes and precision medicine. In this review, we provide detailed implications of the circadian rhythm in neurological diseases through bench-to-bedside approaches. Furthermore, based on the unsatisfactory clinical outcomes, we critically discuss the potential of circadian-based interventions, which may encourage more studies in this discipline, with the hope of improving treatment efficacy in neurological diseases. |
| doi_str_mv | 10.14336/AD.2023.0921 |
| format | Article |
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Recently, a bidirectional relationship between circadian rhythms and several neurological diseases has been reported. Neurological diseases can lead to the disruption of circadian homeostasis, thereby increasing disease severity. Therefore, optimizing the current treatments through circadian-based approaches, including adjusted dosing, changing lifestyle, and targeted interventions, offer a promising opportunity for better clinical outcomes and precision medicine. In this review, we provide detailed implications of the circadian rhythm in neurological diseases through bench-to-bedside approaches. Furthermore, based on the unsatisfactory clinical outcomes, we critically discuss the potential of circadian-based interventions, which may encourage more studies in this discipline, with the hope of improving treatment efficacy in neurological diseases.</description><identifier>ISSN: 2152-5250</identifier><identifier>EISSN: 2152-5250</identifier><identifier>DOI: 10.14336/AD.2023.0921</identifier><identifier>PMID: 37815902</identifier><language>eng</language><publisher>United States: JKL International</publisher><subject>Animals ; Care and treatment ; Circadian Rhythm - physiology ; Circadian rhythms ; Development and progression ; Health aspects ; Humans ; Nervous system diseases ; Nervous System Diseases - metabolism ; Nervous System Diseases - physiopathology ; Nervous System Diseases - therapy ; Physiological aspects ; Review ; Risk factors ; Translational Research, Biomedical</subject><ispartof>Aging and disease, 2024-08, Vol.15 (4), p.1565-1587</ispartof><rights>COPYRIGHT 2024 JKL International</rights><rights>Copyright: © 2024 Huang et al. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-474bc34da474abe0139a5e31f517314906fed9964c68fac584f9b76ad7a00f4b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272204/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272204/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37815902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Wanbin</creatorcontrib><creatorcontrib>Zong, Jiabin</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Zhou, Yanjie</creatorcontrib><creatorcontrib>Zhang, Lily</creatorcontrib><creatorcontrib>Wang, Yajuan</creatorcontrib><creatorcontrib>Shan, Zhengming</creatorcontrib><creatorcontrib>Xie, Qingfang</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Pan, Songqing</creatorcontrib><creatorcontrib>Xiao, Zheman</creatorcontrib><title>The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective</title><title>Aging and disease</title><addtitle>Aging Dis</addtitle><description>Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological and pathophysiological processes in the body. Recently, a bidirectional relationship between circadian rhythms and several neurological diseases has been reported. Neurological diseases can lead to the disruption of circadian homeostasis, thereby increasing disease severity. Therefore, optimizing the current treatments through circadian-based approaches, including adjusted dosing, changing lifestyle, and targeted interventions, offer a promising opportunity for better clinical outcomes and precision medicine. In this review, we provide detailed implications of the circadian rhythm in neurological diseases through bench-to-bedside approaches. Furthermore, based on the unsatisfactory clinical outcomes, we critically discuss the potential of circadian-based interventions, which may encourage more studies in this discipline, with the hope of improving treatment efficacy in neurological diseases.</description><subject>Animals</subject><subject>Care and treatment</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian rhythms</subject><subject>Development and progression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Nervous system diseases</subject><subject>Nervous System Diseases - metabolism</subject><subject>Nervous System Diseases - physiopathology</subject><subject>Nervous System Diseases - therapy</subject><subject>Physiological aspects</subject><subject>Review</subject><subject>Risk factors</subject><subject>Translational Research, Biomedical</subject><issn>2152-5250</issn><issn>2152-5250</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkk1r3DAQhk1paUKaY6_FUCi9eKtP2-qlmN18FEJalu1ZyPJorSJbW8kO5N9X203DLkQ6aNA888LMvFn2HqMFZpSWX5rVgiBCF0gQ_Co7J5iTghOOXh_FZ9lljL9ROlQQKujb7IxWNeYCkfNsvekhX3sHuTf50gatOqvGfN0_Tv2Q2zG_hzl457dWK5evbAQVIX7Nm3wT1BidmqwfU-YnhLgDPdkHeJe9McpFuHx6L7Jf11eb5W1x9-Pm-7K5KzTD5VSwirWask6lQLWAMBWKA8WG44piJlBpoBOiZLqsjdK8Zka0Vam6SiFkWEsvsm8H3d3cDtBpGKegnNwFO6jwKL2y8jQz2l5u_YPEmFSEIJYUPj8pBP9nhjjJwUYNzqkR_BwlqStec8xpmdCPB3SrHEg7Gp8k9R6XTY1YlZYgeKIWL1DpdjBY7UcwNv2fFHw6KuhBuamP3s37qcZTsDiAOvgYA5jnPjGS_7wgm5Xce0HuvZD4D8fDeab_b57-Bbx0rFA</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Huang, Wanbin</creator><creator>Zong, Jiabin</creator><creator>Zhang, Yu</creator><creator>Zhou, Yanjie</creator><creator>Zhang, Lily</creator><creator>Wang, Yajuan</creator><creator>Shan, Zhengming</creator><creator>Xie, Qingfang</creator><creator>Li, Ming</creator><creator>Pan, Songqing</creator><creator>Xiao, Zheman</creator><general>JKL International</general><general>JKL International LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240801</creationdate><title>The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective</title><author>Huang, Wanbin ; Zong, Jiabin ; Zhang, Yu ; Zhou, Yanjie ; Zhang, Lily ; Wang, Yajuan ; Shan, Zhengming ; Xie, Qingfang ; Li, Ming ; Pan, Songqing ; Xiao, Zheman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-474bc34da474abe0139a5e31f517314906fed9964c68fac584f9b76ad7a00f4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Care and treatment</topic><topic>Circadian Rhythm - physiology</topic><topic>Circadian rhythms</topic><topic>Development and progression</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Nervous system diseases</topic><topic>Nervous System Diseases - metabolism</topic><topic>Nervous System Diseases - physiopathology</topic><topic>Nervous System Diseases - therapy</topic><topic>Physiological aspects</topic><topic>Review</topic><topic>Risk factors</topic><topic>Translational Research, Biomedical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Wanbin</creatorcontrib><creatorcontrib>Zong, Jiabin</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Zhou, Yanjie</creatorcontrib><creatorcontrib>Zhang, Lily</creatorcontrib><creatorcontrib>Wang, Yajuan</creatorcontrib><creatorcontrib>Shan, Zhengming</creatorcontrib><creatorcontrib>Xie, Qingfang</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Pan, Songqing</creatorcontrib><creatorcontrib>Xiao, Zheman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Wanbin</au><au>Zong, Jiabin</au><au>Zhang, Yu</au><au>Zhou, Yanjie</au><au>Zhang, Lily</au><au>Wang, Yajuan</au><au>Shan, Zhengming</au><au>Xie, Qingfang</au><au>Li, Ming</au><au>Pan, Songqing</au><au>Xiao, Zheman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective</atitle><jtitle>Aging and disease</jtitle><addtitle>Aging Dis</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>15</volume><issue>4</issue><spage>1565</spage><epage>1587</epage><pages>1565-1587</pages><issn>2152-5250</issn><eissn>2152-5250</eissn><abstract>Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological and pathophysiological processes in the body. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Care and treatment Circadian Rhythm - physiology Circadian rhythms Development and progression Health aspects Humans Nervous system diseases Nervous System Diseases - metabolism Nervous System Diseases - physiopathology Nervous System Diseases - therapy Physiological aspects Review Risk factors Translational Research, Biomedical |
| title | The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective |
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