Evaluating the Clinical Impact and Feasibility of Therapeutic Drug Monitoring of Pazopanib in a Real-World Soft-Tissue Sarcoma Cohort

Introduction and Objective Pazopanib is registered for metastatic renal cell carcinoma and soft-tissue sarcoma (STS). Its variable pharmacokinetic (PK) characteristics and narrow therapeutic range provide a strong rationale for therapeutic drug monitoring (TDM). Prior studies have defined target lev...

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Veröffentlicht in:	Clinical pharmacokinetics 2024-07, Vol.63 (7), p.1045-1054
Hauptverfasser:	Meertens, Marinda, Giraud, Eline L., van der Kleij, Maud B. A., Westerdijk, Kim, Guchelaar, Niels A. D., Bleckman, Roos F., Rieborn, Amy, Imholz, Alex L. T, Otten, Hans-Martin, Vulink, Annelie, Los, Maartje, Hamberg, Paul, van der Graaf, Winette T. A., Gelderblom, Hans, Moes, Dirk Jan A. R., Broekman, K. Esther, Touw, Daan J., Koolen, Stijn L. W., Mathijssen, Ron H. J., Huitema, Alwin D. R., van Erp, Nielka P., Desar, Ingrid M. E., Steeghs, Neeltje
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacokinetics Angiogenesis Inhibitors - therapeutic use Cohort Studies Drug dosages Drug Monitoring - methods Feasibility Feasibility Studies Female Growth factors Humans Indazoles - pharmacokinetics Inhibitor drugs Internal Medicine Intervention Kidney cancer Male Medicine Medicine & Public Health Metastasis Middle Aged Oncology Original Original Research Article Patients Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Progression-Free Survival Pyrimidines - administration & dosage Pyrimidines - pharmacokinetics Pyrimidines - therapeutic use Retrospective Studies Sarcoma Sarcoma - drug therapy Sulfonamides - administration & dosage Sulfonamides - pharmacokinetics Sulfonamides - therapeutic use Targeted cancer therapy Therapeutic drug monitoring Toxicity
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