Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa

Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent’s past. However, while international interest in human genomics research in Africa grows, major structural barrie...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of human genetics 2024-07, Vol.111 (7), p.1243-1251
Hauptverfasser: Sawchuk, Elizabeth A., Sirak, Kendra A., Manthi, Fredrick K., Ndiema, Emmanuel K., Ogola, Christine A., Prendergast, Mary E., Reich, David, Aluvaala, Eva, Ayodo, George, Badji, Lamine, Bird, Nancy, Black, Wendy, Fregel, Rosa, Gachihi, Njeri, Gibbon, Victoria E., Gidna, Agness, Goldstein, Steven T., Hamad, Reem, Hassan, Hisham Y., Hayes, Vanessa M., Hellenthal, Garrett, Kebede, Solomon, Kurewa, Abdikadir, Kusimba, Chapurukha, Kyazike, Elizabeth, Lane, Paul J., MacEachern, Scott, Massilani, Diyendo, Mbua, Emma, Morris, Alan G., Mutinda, Christina, M’Mbogori, Freda Nkirote, Reynolds, Austin W., Tishkoff, Sarah, Vilar, Miguel, Yimer, Getnet
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1251
container_issue 7
container_start_page 1243
container_title American journal of human genetics
container_volume 111
creator Sawchuk, Elizabeth A.
Sirak, Kendra A.
Manthi, Fredrick K.
Ndiema, Emmanuel K.
Ogola, Christine A.
Prendergast, Mary E.
Reich, David
Aluvaala, Eva
Ayodo, George
Badji, Lamine
Bird, Nancy
Black, Wendy
Fregel, Rosa
Gachihi, Njeri
Gibbon, Victoria E.
Gidna, Agness
Goldstein, Steven T.
Hamad, Reem
Hassan, Hisham Y.
Hayes, Vanessa M.
Hellenthal, Garrett
Kebede, Solomon
Kurewa, Abdikadir
Kusimba, Chapurukha
Kyazike, Elizabeth
Lane, Paul J.
MacEachern, Scott
Massilani, Diyendo
Mbua, Emma
Morris, Alan G.
Mutinda, Christina
M’Mbogori, Freda Nkirote
Reynolds, Austin W.
Tishkoff, Sarah
Vilar, Miguel
Yimer, Getnet
description Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent’s past. However, while international interest in human genomics research in Africa grows, major structural barriers limit the ability of African scholars to lead and engage in such research and impede local communities from partnering with researchers and benefitting from research outcomes. Because conversations about research on African people and their past are often held outside Africa and exclude African voices, an important step for African DNA and aDNA research is moving these conversations to the continent. In May 2023 we held the DNAirobi workshop in Nairobi, Kenya and here we synthesize what emerged most prominently in our discussions. We propose an ideal vision for population history-focused DNA and aDNA research in Africa in ten years’ time and acknowledge that to realize this future, we need to chart a path connecting a series of “landmarks” that represent points of consensus in our discussions. These include effective communication across multiple audiences, reframed relationships and capacity building, and action toward structural changes that support science and beyond. We concluded there is no single path to creating an equitable and self-sustaining research ecosystem, but rather many possible routes linking these landmarks. Here we share our diverse perspectives as geneticists, anthropologists, archaeologists, museum curators, and educators to articulate challenges and opportunities for African DNA and aDNA research and share an initial map toward a more inclusive and equitable future. Moving toward an increasingly inclusive, equitable, and engaged future for population history-focused African DNA and aDNA research requires identifying existing barriers and proposing solutions to overcome them. We create a vision for the next decade of research and identify the landmarks that will collectively bring us closer to this goal.
doi_str_mv 10.1016/j.ajhg.2024.05.019
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11267517</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002929724001824</els_id><sourcerecordid>3079855073</sourcerecordid><originalsourceid>FETCH-LOGICAL-c293t-d350a9d37bedb55d63a63315b44d8be8641d650499a9cba93d9e5d8a76c6efe33</originalsourceid><addsrcrecordid>eNp9UcGO0zAQtRCI7S78AAfkI5cEO46dWEJCVYEFaQUXOFsTe9K4pHGw0yL-HkddVnDhMJrDvPdm5j1CXnBWcsbV60MJh2FfVqyqSyZLxvUjsuFSNIVSTD4mG8ZYVehKN1fkOqUDY5y3TDwlV6LVWtVKbki3GyAuftpToCNM7gjxe-GiP-NEZ1gG2of4E6JbO53DfBph8WGie5xw8TbRzMllPU4Lffd5SyMmhGgH6ie67aO38Iw86WFM-Py-35BvH95_3X0s7r7cftpt7wpbabEUTkgG2ommQ9dJ6ZQAJQSXXV27tsNW1dwpyWqtQdsOtHAapWuhUVZhj0LckLcX3fnUHdHZfFGE0czR56d-mQDe_DuZ_GD24Ww4r1QjeZMVXt0rxPDjhGkxR58sjtkYDKdkBGt0KyVr1mXVBWpjSCli_7CHM7OmYw5mTces6RgmTU4nk17-feED5U8cGfDmAsDs09ljNGl11qLzEe1iXPD_0_8NZFyivA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3079855073</pqid></control><display><type>article</type><title>Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Sawchuk, Elizabeth A. ; Sirak, Kendra A. ; Manthi, Fredrick K. ; Ndiema, Emmanuel K. ; Ogola, Christine A. ; Prendergast, Mary E. ; Reich, David ; Aluvaala, Eva ; Ayodo, George ; Badji, Lamine ; Bird, Nancy ; Black, Wendy ; Fregel, Rosa ; Gachihi, Njeri ; Gibbon, Victoria E. ; Gidna, Agness ; Goldstein, Steven T. ; Hamad, Reem ; Hassan, Hisham Y. ; Hayes, Vanessa M. ; Hellenthal, Garrett ; Kebede, Solomon ; Kurewa, Abdikadir ; Kusimba, Chapurukha ; Kyazike, Elizabeth ; Lane, Paul J. ; MacEachern, Scott ; Massilani, Diyendo ; Mbua, Emma ; Morris, Alan G. ; Mutinda, Christina ; M’Mbogori, Freda Nkirote ; Reynolds, Austin W. ; Tishkoff, Sarah ; Vilar, Miguel ; Yimer, Getnet</creator><creatorcontrib>Sawchuk, Elizabeth A. ; Sirak, Kendra A. ; Manthi, Fredrick K. ; Ndiema, Emmanuel K. ; Ogola, Christine A. ; Prendergast, Mary E. ; Reich, David ; Aluvaala, Eva ; Ayodo, George ; Badji, Lamine ; Bird, Nancy ; Black, Wendy ; Fregel, Rosa ; Gachihi, Njeri ; Gibbon, Victoria E. ; Gidna, Agness ; Goldstein, Steven T. ; Hamad, Reem ; Hassan, Hisham Y. ; Hayes, Vanessa M. ; Hellenthal, Garrett ; Kebede, Solomon ; Kurewa, Abdikadir ; Kusimba, Chapurukha ; Kyazike, Elizabeth ; Lane, Paul J. ; MacEachern, Scott ; Massilani, Diyendo ; Mbua, Emma ; Morris, Alan G. ; Mutinda, Christina ; M’Mbogori, Freda Nkirote ; Reynolds, Austin W. ; Tishkoff, Sarah ; Vilar, Miguel ; Yimer, Getnet</creatorcontrib><description>Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent’s past. However, while international interest in human genomics research in Africa grows, major structural barriers limit the ability of African scholars to lead and engage in such research and impede local communities from partnering with researchers and benefitting from research outcomes. Because conversations about research on African people and their past are often held outside Africa and exclude African voices, an important step for African DNA and aDNA research is moving these conversations to the continent. In May 2023 we held the DNAirobi workshop in Nairobi, Kenya and here we synthesize what emerged most prominently in our discussions. We propose an ideal vision for population history-focused DNA and aDNA research in Africa in ten years’ time and acknowledge that to realize this future, we need to chart a path connecting a series of “landmarks” that represent points of consensus in our discussions. These include effective communication across multiple audiences, reframed relationships and capacity building, and action toward structural changes that support science and beyond. We concluded there is no single path to creating an equitable and self-sustaining research ecosystem, but rather many possible routes linking these landmarks. Here we share our diverse perspectives as geneticists, anthropologists, archaeologists, museum curators, and educators to articulate challenges and opportunities for African DNA and aDNA research and share an initial map toward a more inclusive and equitable future. Moving toward an increasingly inclusive, equitable, and engaged future for population history-focused African DNA and aDNA research requires identifying existing barriers and proposing solutions to overcome them. We create a vision for the next decade of research and identify the landmarks that will collectively bring us closer to this goal.</description><identifier>ISSN: 0002-9297</identifier><identifier>ISSN: 1537-6605</identifier><identifier>EISSN: 1537-6605</identifier><identifier>DOI: 10.1016/j.ajhg.2024.05.019</identifier><identifier>PMID: 38996465</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Africa ; Black People - genetics ; capacity building ; community engagement ; DNA, Ancient - analysis ; genetics research ; Genetics, Population ; Genomics ; Humans ; population history</subject><ispartof>American journal of human genetics, 2024-07, Vol.111 (7), p.1243-1251</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.</rights><rights>2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c293t-d350a9d37bedb55d63a63315b44d8be8641d650499a9cba93d9e5d8a76c6efe33</cites><orcidid>0000-0003-4398-2174</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajhg.2024.05.019$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38996465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawchuk, Elizabeth A.</creatorcontrib><creatorcontrib>Sirak, Kendra A.</creatorcontrib><creatorcontrib>Manthi, Fredrick K.</creatorcontrib><creatorcontrib>Ndiema, Emmanuel K.</creatorcontrib><creatorcontrib>Ogola, Christine A.</creatorcontrib><creatorcontrib>Prendergast, Mary E.</creatorcontrib><creatorcontrib>Reich, David</creatorcontrib><creatorcontrib>Aluvaala, Eva</creatorcontrib><creatorcontrib>Ayodo, George</creatorcontrib><creatorcontrib>Badji, Lamine</creatorcontrib><creatorcontrib>Bird, Nancy</creatorcontrib><creatorcontrib>Black, Wendy</creatorcontrib><creatorcontrib>Fregel, Rosa</creatorcontrib><creatorcontrib>Gachihi, Njeri</creatorcontrib><creatorcontrib>Gibbon, Victoria E.</creatorcontrib><creatorcontrib>Gidna, Agness</creatorcontrib><creatorcontrib>Goldstein, Steven T.</creatorcontrib><creatorcontrib>Hamad, Reem</creatorcontrib><creatorcontrib>Hassan, Hisham Y.</creatorcontrib><creatorcontrib>Hayes, Vanessa M.</creatorcontrib><creatorcontrib>Hellenthal, Garrett</creatorcontrib><creatorcontrib>Kebede, Solomon</creatorcontrib><creatorcontrib>Kurewa, Abdikadir</creatorcontrib><creatorcontrib>Kusimba, Chapurukha</creatorcontrib><creatorcontrib>Kyazike, Elizabeth</creatorcontrib><creatorcontrib>Lane, Paul J.</creatorcontrib><creatorcontrib>MacEachern, Scott</creatorcontrib><creatorcontrib>Massilani, Diyendo</creatorcontrib><creatorcontrib>Mbua, Emma</creatorcontrib><creatorcontrib>Morris, Alan G.</creatorcontrib><creatorcontrib>Mutinda, Christina</creatorcontrib><creatorcontrib>M’Mbogori, Freda Nkirote</creatorcontrib><creatorcontrib>Reynolds, Austin W.</creatorcontrib><creatorcontrib>Tishkoff, Sarah</creatorcontrib><creatorcontrib>Vilar, Miguel</creatorcontrib><creatorcontrib>Yimer, Getnet</creatorcontrib><title>Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa</title><title>American journal of human genetics</title><addtitle>Am J Hum Genet</addtitle><description>Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent’s past. However, while international interest in human genomics research in Africa grows, major structural barriers limit the ability of African scholars to lead and engage in such research and impede local communities from partnering with researchers and benefitting from research outcomes. Because conversations about research on African people and their past are often held outside Africa and exclude African voices, an important step for African DNA and aDNA research is moving these conversations to the continent. In May 2023 we held the DNAirobi workshop in Nairobi, Kenya and here we synthesize what emerged most prominently in our discussions. We propose an ideal vision for population history-focused DNA and aDNA research in Africa in ten years’ time and acknowledge that to realize this future, we need to chart a path connecting a series of “landmarks” that represent points of consensus in our discussions. These include effective communication across multiple audiences, reframed relationships and capacity building, and action toward structural changes that support science and beyond. We concluded there is no single path to creating an equitable and self-sustaining research ecosystem, but rather many possible routes linking these landmarks. Here we share our diverse perspectives as geneticists, anthropologists, archaeologists, museum curators, and educators to articulate challenges and opportunities for African DNA and aDNA research and share an initial map toward a more inclusive and equitable future. Moving toward an increasingly inclusive, equitable, and engaged future for population history-focused African DNA and aDNA research requires identifying existing barriers and proposing solutions to overcome them. We create a vision for the next decade of research and identify the landmarks that will collectively bring us closer to this goal.</description><subject>Africa</subject><subject>Black People - genetics</subject><subject>capacity building</subject><subject>community engagement</subject><subject>DNA, Ancient - analysis</subject><subject>genetics research</subject><subject>Genetics, Population</subject><subject>Genomics</subject><subject>Humans</subject><subject>population history</subject><issn>0002-9297</issn><issn>1537-6605</issn><issn>1537-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcGO0zAQtRCI7S78AAfkI5cEO46dWEJCVYEFaQUXOFsTe9K4pHGw0yL-HkddVnDhMJrDvPdm5j1CXnBWcsbV60MJh2FfVqyqSyZLxvUjsuFSNIVSTD4mG8ZYVehKN1fkOqUDY5y3TDwlV6LVWtVKbki3GyAuftpToCNM7gjxe-GiP-NEZ1gG2of4E6JbO53DfBph8WGie5xw8TbRzMllPU4Lffd5SyMmhGgH6ie67aO38Iw86WFM-Py-35BvH95_3X0s7r7cftpt7wpbabEUTkgG2ommQ9dJ6ZQAJQSXXV27tsNW1dwpyWqtQdsOtHAapWuhUVZhj0LckLcX3fnUHdHZfFGE0czR56d-mQDe_DuZ_GD24Ww4r1QjeZMVXt0rxPDjhGkxR58sjtkYDKdkBGt0KyVr1mXVBWpjSCli_7CHM7OmYw5mTces6RgmTU4nk17-feED5U8cGfDmAsDs09ljNGl11qLzEe1iXPD_0_8NZFyivA</recordid><startdate>20240711</startdate><enddate>20240711</enddate><creator>Sawchuk, Elizabeth A.</creator><creator>Sirak, Kendra A.</creator><creator>Manthi, Fredrick K.</creator><creator>Ndiema, Emmanuel K.</creator><creator>Ogola, Christine A.</creator><creator>Prendergast, Mary E.</creator><creator>Reich, David</creator><creator>Aluvaala, Eva</creator><creator>Ayodo, George</creator><creator>Badji, Lamine</creator><creator>Bird, Nancy</creator><creator>Black, Wendy</creator><creator>Fregel, Rosa</creator><creator>Gachihi, Njeri</creator><creator>Gibbon, Victoria E.</creator><creator>Gidna, Agness</creator><creator>Goldstein, Steven T.</creator><creator>Hamad, Reem</creator><creator>Hassan, Hisham Y.</creator><creator>Hayes, Vanessa M.</creator><creator>Hellenthal, Garrett</creator><creator>Kebede, Solomon</creator><creator>Kurewa, Abdikadir</creator><creator>Kusimba, Chapurukha</creator><creator>Kyazike, Elizabeth</creator><creator>Lane, Paul J.</creator><creator>MacEachern, Scott</creator><creator>Massilani, Diyendo</creator><creator>Mbua, Emma</creator><creator>Morris, Alan G.</creator><creator>Mutinda, Christina</creator><creator>M’Mbogori, Freda Nkirote</creator><creator>Reynolds, Austin W.</creator><creator>Tishkoff, Sarah</creator><creator>Vilar, Miguel</creator><creator>Yimer, Getnet</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4398-2174</orcidid></search><sort><creationdate>20240711</creationdate><title>Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa</title><author>Sawchuk, Elizabeth A. ; Sirak, Kendra A. ; Manthi, Fredrick K. ; Ndiema, Emmanuel K. ; Ogola, Christine A. ; Prendergast, Mary E. ; Reich, David ; Aluvaala, Eva ; Ayodo, George ; Badji, Lamine ; Bird, Nancy ; Black, Wendy ; Fregel, Rosa ; Gachihi, Njeri ; Gibbon, Victoria E. ; Gidna, Agness ; Goldstein, Steven T. ; Hamad, Reem ; Hassan, Hisham Y. ; Hayes, Vanessa M. ; Hellenthal, Garrett ; Kebede, Solomon ; Kurewa, Abdikadir ; Kusimba, Chapurukha ; Kyazike, Elizabeth ; Lane, Paul J. ; MacEachern, Scott ; Massilani, Diyendo ; Mbua, Emma ; Morris, Alan G. ; Mutinda, Christina ; M’Mbogori, Freda Nkirote ; Reynolds, Austin W. ; Tishkoff, Sarah ; Vilar, Miguel ; Yimer, Getnet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-d350a9d37bedb55d63a63315b44d8be8641d650499a9cba93d9e5d8a76c6efe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Africa</topic><topic>Black People - genetics</topic><topic>capacity building</topic><topic>community engagement</topic><topic>DNA, Ancient - analysis</topic><topic>genetics research</topic><topic>Genetics, Population</topic><topic>Genomics</topic><topic>Humans</topic><topic>population history</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawchuk, Elizabeth A.</creatorcontrib><creatorcontrib>Sirak, Kendra A.</creatorcontrib><creatorcontrib>Manthi, Fredrick K.</creatorcontrib><creatorcontrib>Ndiema, Emmanuel K.</creatorcontrib><creatorcontrib>Ogola, Christine A.</creatorcontrib><creatorcontrib>Prendergast, Mary E.</creatorcontrib><creatorcontrib>Reich, David</creatorcontrib><creatorcontrib>Aluvaala, Eva</creatorcontrib><creatorcontrib>Ayodo, George</creatorcontrib><creatorcontrib>Badji, Lamine</creatorcontrib><creatorcontrib>Bird, Nancy</creatorcontrib><creatorcontrib>Black, Wendy</creatorcontrib><creatorcontrib>Fregel, Rosa</creatorcontrib><creatorcontrib>Gachihi, Njeri</creatorcontrib><creatorcontrib>Gibbon, Victoria E.</creatorcontrib><creatorcontrib>Gidna, Agness</creatorcontrib><creatorcontrib>Goldstein, Steven T.</creatorcontrib><creatorcontrib>Hamad, Reem</creatorcontrib><creatorcontrib>Hassan, Hisham Y.</creatorcontrib><creatorcontrib>Hayes, Vanessa M.</creatorcontrib><creatorcontrib>Hellenthal, Garrett</creatorcontrib><creatorcontrib>Kebede, Solomon</creatorcontrib><creatorcontrib>Kurewa, Abdikadir</creatorcontrib><creatorcontrib>Kusimba, Chapurukha</creatorcontrib><creatorcontrib>Kyazike, Elizabeth</creatorcontrib><creatorcontrib>Lane, Paul J.</creatorcontrib><creatorcontrib>MacEachern, Scott</creatorcontrib><creatorcontrib>Massilani, Diyendo</creatorcontrib><creatorcontrib>Mbua, Emma</creatorcontrib><creatorcontrib>Morris, Alan G.</creatorcontrib><creatorcontrib>Mutinda, Christina</creatorcontrib><creatorcontrib>M’Mbogori, Freda Nkirote</creatorcontrib><creatorcontrib>Reynolds, Austin W.</creatorcontrib><creatorcontrib>Tishkoff, Sarah</creatorcontrib><creatorcontrib>Vilar, Miguel</creatorcontrib><creatorcontrib>Yimer, Getnet</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawchuk, Elizabeth A.</au><au>Sirak, Kendra A.</au><au>Manthi, Fredrick K.</au><au>Ndiema, Emmanuel K.</au><au>Ogola, Christine A.</au><au>Prendergast, Mary E.</au><au>Reich, David</au><au>Aluvaala, Eva</au><au>Ayodo, George</au><au>Badji, Lamine</au><au>Bird, Nancy</au><au>Black, Wendy</au><au>Fregel, Rosa</au><au>Gachihi, Njeri</au><au>Gibbon, Victoria E.</au><au>Gidna, Agness</au><au>Goldstein, Steven T.</au><au>Hamad, Reem</au><au>Hassan, Hisham Y.</au><au>Hayes, Vanessa M.</au><au>Hellenthal, Garrett</au><au>Kebede, Solomon</au><au>Kurewa, Abdikadir</au><au>Kusimba, Chapurukha</au><au>Kyazike, Elizabeth</au><au>Lane, Paul J.</au><au>MacEachern, Scott</au><au>Massilani, Diyendo</au><au>Mbua, Emma</au><au>Morris, Alan G.</au><au>Mutinda, Christina</au><au>M’Mbogori, Freda Nkirote</au><au>Reynolds, Austin W.</au><au>Tishkoff, Sarah</au><au>Vilar, Miguel</au><au>Yimer, Getnet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa</atitle><jtitle>American journal of human genetics</jtitle><addtitle>Am J Hum Genet</addtitle><date>2024-07-11</date><risdate>2024</risdate><volume>111</volume><issue>7</issue><spage>1243</spage><epage>1251</epage><pages>1243-1251</pages><issn>0002-9297</issn><issn>1537-6605</issn><eissn>1537-6605</eissn><abstract>Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent’s past. However, while international interest in human genomics research in Africa grows, major structural barriers limit the ability of African scholars to lead and engage in such research and impede local communities from partnering with researchers and benefitting from research outcomes. Because conversations about research on African people and their past are often held outside Africa and exclude African voices, an important step for African DNA and aDNA research is moving these conversations to the continent. In May 2023 we held the DNAirobi workshop in Nairobi, Kenya and here we synthesize what emerged most prominently in our discussions. We propose an ideal vision for population history-focused DNA and aDNA research in Africa in ten years’ time and acknowledge that to realize this future, we need to chart a path connecting a series of “landmarks” that represent points of consensus in our discussions. These include effective communication across multiple audiences, reframed relationships and capacity building, and action toward structural changes that support science and beyond. We concluded there is no single path to creating an equitable and self-sustaining research ecosystem, but rather many possible routes linking these landmarks. Here we share our diverse perspectives as geneticists, anthropologists, archaeologists, museum curators, and educators to articulate challenges and opportunities for African DNA and aDNA research and share an initial map toward a more inclusive and equitable future. Moving toward an increasingly inclusive, equitable, and engaged future for population history-focused African DNA and aDNA research requires identifying existing barriers and proposing solutions to overcome them. We create a vision for the next decade of research and identify the landmarks that will collectively bring us closer to this goal.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38996465</pmid><doi>10.1016/j.ajhg.2024.05.019</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4398-2174</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0002-9297
ispartof American journal of human genetics, 2024-07, Vol.111 (7), p.1243-1251
issn 0002-9297
1537-6605
1537-6605
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11267517
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Africa
Black People - genetics
capacity building
community engagement
DNA, Ancient - analysis
genetics research
Genetics, Population
Genomics
Humans
population history
title Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T14%3A51%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Charting%20a%20landmark-driven%20path%20forward%20for%20population%20genetics%20and%20ancient%20DNA%20research%20in%20Africa&rft.jtitle=American%20journal%20of%20human%20genetics&rft.au=Sawchuk,%20Elizabeth%20A.&rft.date=2024-07-11&rft.volume=111&rft.issue=7&rft.spage=1243&rft.epage=1251&rft.pages=1243-1251&rft.issn=0002-9297&rft.eissn=1537-6605&rft_id=info:doi/10.1016/j.ajhg.2024.05.019&rft_dat=%3Cproquest_pubme%3E3079855073%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3079855073&rft_id=info:pmid/38996465&rft_els_id=S0002929724001824&rfr_iscdi=true