Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa
Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent’s past. However, while international interest in human genomics research in Africa grows, major structural barrie...
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creator | Sawchuk, Elizabeth A. Sirak, Kendra A. Manthi, Fredrick K. Ndiema, Emmanuel K. Ogola, Christine A. Prendergast, Mary E. Reich, David Aluvaala, Eva Ayodo, George Badji, Lamine Bird, Nancy Black, Wendy Fregel, Rosa Gachihi, Njeri Gibbon, Victoria E. Gidna, Agness Goldstein, Steven T. Hamad, Reem Hassan, Hisham Y. Hayes, Vanessa M. Hellenthal, Garrett Kebede, Solomon Kurewa, Abdikadir Kusimba, Chapurukha Kyazike, Elizabeth Lane, Paul J. MacEachern, Scott Massilani, Diyendo Mbua, Emma Morris, Alan G. Mutinda, Christina M’Mbogori, Freda Nkirote Reynolds, Austin W. Tishkoff, Sarah Vilar, Miguel Yimer, Getnet |
description | Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent’s past. However, while international interest in human genomics research in Africa grows, major structural barriers limit the ability of African scholars to lead and engage in such research and impede local communities from partnering with researchers and benefitting from research outcomes. Because conversations about research on African people and their past are often held outside Africa and exclude African voices, an important step for African DNA and aDNA research is moving these conversations to the continent. In May 2023 we held the DNAirobi workshop in Nairobi, Kenya and here we synthesize what emerged most prominently in our discussions. We propose an ideal vision for population history-focused DNA and aDNA research in Africa in ten years’ time and acknowledge that to realize this future, we need to chart a path connecting a series of “landmarks” that represent points of consensus in our discussions. These include effective communication across multiple audiences, reframed relationships and capacity building, and action toward structural changes that support science and beyond. We concluded there is no single path to creating an equitable and self-sustaining research ecosystem, but rather many possible routes linking these landmarks. Here we share our diverse perspectives as geneticists, anthropologists, archaeologists, museum curators, and educators to articulate challenges and opportunities for African DNA and aDNA research and share an initial map toward a more inclusive and equitable future.
Moving toward an increasingly inclusive, equitable, and engaged future for population history-focused African DNA and aDNA research requires identifying existing barriers and proposing solutions to overcome them. We create a vision for the next decade of research and identify the landmarks that will collectively bring us closer to this goal. |
doi_str_mv | 10.1016/j.ajhg.2024.05.019 |
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Moving toward an increasingly inclusive, equitable, and engaged future for population history-focused African DNA and aDNA research requires identifying existing barriers and proposing solutions to overcome them. 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All rights reserved.</rights><rights>2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c293t-d350a9d37bedb55d63a63315b44d8be8641d650499a9cba93d9e5d8a76c6efe33</cites><orcidid>0000-0003-4398-2174</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajhg.2024.05.019$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38996465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawchuk, Elizabeth A.</creatorcontrib><creatorcontrib>Sirak, Kendra A.</creatorcontrib><creatorcontrib>Manthi, Fredrick K.</creatorcontrib><creatorcontrib>Ndiema, Emmanuel K.</creatorcontrib><creatorcontrib>Ogola, Christine A.</creatorcontrib><creatorcontrib>Prendergast, Mary E.</creatorcontrib><creatorcontrib>Reich, David</creatorcontrib><creatorcontrib>Aluvaala, Eva</creatorcontrib><creatorcontrib>Ayodo, George</creatorcontrib><creatorcontrib>Badji, Lamine</creatorcontrib><creatorcontrib>Bird, Nancy</creatorcontrib><creatorcontrib>Black, Wendy</creatorcontrib><creatorcontrib>Fregel, Rosa</creatorcontrib><creatorcontrib>Gachihi, Njeri</creatorcontrib><creatorcontrib>Gibbon, Victoria E.</creatorcontrib><creatorcontrib>Gidna, Agness</creatorcontrib><creatorcontrib>Goldstein, Steven T.</creatorcontrib><creatorcontrib>Hamad, Reem</creatorcontrib><creatorcontrib>Hassan, Hisham Y.</creatorcontrib><creatorcontrib>Hayes, Vanessa M.</creatorcontrib><creatorcontrib>Hellenthal, Garrett</creatorcontrib><creatorcontrib>Kebede, Solomon</creatorcontrib><creatorcontrib>Kurewa, Abdikadir</creatorcontrib><creatorcontrib>Kusimba, Chapurukha</creatorcontrib><creatorcontrib>Kyazike, Elizabeth</creatorcontrib><creatorcontrib>Lane, Paul J.</creatorcontrib><creatorcontrib>MacEachern, Scott</creatorcontrib><creatorcontrib>Massilani, Diyendo</creatorcontrib><creatorcontrib>Mbua, Emma</creatorcontrib><creatorcontrib>Morris, Alan G.</creatorcontrib><creatorcontrib>Mutinda, Christina</creatorcontrib><creatorcontrib>M’Mbogori, Freda Nkirote</creatorcontrib><creatorcontrib>Reynolds, Austin W.</creatorcontrib><creatorcontrib>Tishkoff, Sarah</creatorcontrib><creatorcontrib>Vilar, Miguel</creatorcontrib><creatorcontrib>Yimer, Getnet</creatorcontrib><title>Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa</title><title>American journal of human genetics</title><addtitle>Am J Hum Genet</addtitle><description>Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent’s past. However, while international interest in human genomics research in Africa grows, major structural barriers limit the ability of African scholars to lead and engage in such research and impede local communities from partnering with researchers and benefitting from research outcomes. Because conversations about research on African people and their past are often held outside Africa and exclude African voices, an important step for African DNA and aDNA research is moving these conversations to the continent. In May 2023 we held the DNAirobi workshop in Nairobi, Kenya and here we synthesize what emerged most prominently in our discussions. We propose an ideal vision for population history-focused DNA and aDNA research in Africa in ten years’ time and acknowledge that to realize this future, we need to chart a path connecting a series of “landmarks” that represent points of consensus in our discussions. These include effective communication across multiple audiences, reframed relationships and capacity building, and action toward structural changes that support science and beyond. We concluded there is no single path to creating an equitable and self-sustaining research ecosystem, but rather many possible routes linking these landmarks. Here we share our diverse perspectives as geneticists, anthropologists, archaeologists, museum curators, and educators to articulate challenges and opportunities for African DNA and aDNA research and share an initial map toward a more inclusive and equitable future.
Moving toward an increasingly inclusive, equitable, and engaged future for population history-focused African DNA and aDNA research requires identifying existing barriers and proposing solutions to overcome them. We create a vision for the next decade of research and identify the landmarks that will collectively bring us closer to this goal.</description><subject>Africa</subject><subject>Black People - genetics</subject><subject>capacity building</subject><subject>community engagement</subject><subject>DNA, Ancient - analysis</subject><subject>genetics research</subject><subject>Genetics, Population</subject><subject>Genomics</subject><subject>Humans</subject><subject>population history</subject><issn>0002-9297</issn><issn>1537-6605</issn><issn>1537-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcGO0zAQtRCI7S78AAfkI5cEO46dWEJCVYEFaQUXOFsTe9K4pHGw0yL-HkddVnDhMJrDvPdm5j1CXnBWcsbV60MJh2FfVqyqSyZLxvUjsuFSNIVSTD4mG8ZYVehKN1fkOqUDY5y3TDwlV6LVWtVKbki3GyAuftpToCNM7gjxe-GiP-NEZ1gG2of4E6JbO53DfBph8WGie5xw8TbRzMllPU4Lffd5SyMmhGgH6ie67aO38Iw86WFM-Py-35BvH95_3X0s7r7cftpt7wpbabEUTkgG2ommQ9dJ6ZQAJQSXXV27tsNW1dwpyWqtQdsOtHAapWuhUVZhj0LckLcX3fnUHdHZfFGE0czR56d-mQDe_DuZ_GD24Ww4r1QjeZMVXt0rxPDjhGkxR58sjtkYDKdkBGt0KyVr1mXVBWpjSCli_7CHM7OmYw5mTces6RgmTU4nk17-feED5U8cGfDmAsDs09ljNGl11qLzEe1iXPD_0_8NZFyivA</recordid><startdate>20240711</startdate><enddate>20240711</enddate><creator>Sawchuk, Elizabeth A.</creator><creator>Sirak, Kendra A.</creator><creator>Manthi, Fredrick K.</creator><creator>Ndiema, Emmanuel K.</creator><creator>Ogola, Christine A.</creator><creator>Prendergast, Mary E.</creator><creator>Reich, David</creator><creator>Aluvaala, Eva</creator><creator>Ayodo, George</creator><creator>Badji, Lamine</creator><creator>Bird, Nancy</creator><creator>Black, Wendy</creator><creator>Fregel, Rosa</creator><creator>Gachihi, Njeri</creator><creator>Gibbon, Victoria E.</creator><creator>Gidna, Agness</creator><creator>Goldstein, Steven T.</creator><creator>Hamad, Reem</creator><creator>Hassan, Hisham Y.</creator><creator>Hayes, Vanessa M.</creator><creator>Hellenthal, Garrett</creator><creator>Kebede, Solomon</creator><creator>Kurewa, Abdikadir</creator><creator>Kusimba, Chapurukha</creator><creator>Kyazike, Elizabeth</creator><creator>Lane, Paul J.</creator><creator>MacEachern, Scott</creator><creator>Massilani, Diyendo</creator><creator>Mbua, Emma</creator><creator>Morris, Alan G.</creator><creator>Mutinda, Christina</creator><creator>M’Mbogori, Freda Nkirote</creator><creator>Reynolds, Austin W.</creator><creator>Tishkoff, Sarah</creator><creator>Vilar, Miguel</creator><creator>Yimer, Getnet</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4398-2174</orcidid></search><sort><creationdate>20240711</creationdate><title>Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa</title><author>Sawchuk, Elizabeth A. ; Sirak, Kendra A. ; Manthi, Fredrick K. ; Ndiema, Emmanuel K. ; Ogola, Christine A. ; Prendergast, Mary E. ; Reich, David ; Aluvaala, Eva ; Ayodo, George ; Badji, Lamine ; Bird, Nancy ; Black, Wendy ; Fregel, Rosa ; Gachihi, Njeri ; Gibbon, Victoria E. ; Gidna, Agness ; Goldstein, Steven T. ; Hamad, Reem ; Hassan, Hisham Y. ; Hayes, Vanessa M. ; Hellenthal, Garrett ; Kebede, Solomon ; Kurewa, Abdikadir ; Kusimba, Chapurukha ; Kyazike, Elizabeth ; Lane, Paul J. ; MacEachern, Scott ; Massilani, Diyendo ; Mbua, Emma ; Morris, Alan G. ; Mutinda, Christina ; M’Mbogori, Freda Nkirote ; Reynolds, Austin W. ; Tishkoff, Sarah ; Vilar, Miguel ; Yimer, Getnet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-d350a9d37bedb55d63a63315b44d8be8641d650499a9cba93d9e5d8a76c6efe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Africa</topic><topic>Black People - 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However, while international interest in human genomics research in Africa grows, major structural barriers limit the ability of African scholars to lead and engage in such research and impede local communities from partnering with researchers and benefitting from research outcomes. Because conversations about research on African people and their past are often held outside Africa and exclude African voices, an important step for African DNA and aDNA research is moving these conversations to the continent. In May 2023 we held the DNAirobi workshop in Nairobi, Kenya and here we synthesize what emerged most prominently in our discussions. We propose an ideal vision for population history-focused DNA and aDNA research in Africa in ten years’ time and acknowledge that to realize this future, we need to chart a path connecting a series of “landmarks” that represent points of consensus in our discussions. These include effective communication across multiple audiences, reframed relationships and capacity building, and action toward structural changes that support science and beyond. We concluded there is no single path to creating an equitable and self-sustaining research ecosystem, but rather many possible routes linking these landmarks. Here we share our diverse perspectives as geneticists, anthropologists, archaeologists, museum curators, and educators to articulate challenges and opportunities for African DNA and aDNA research and share an initial map toward a more inclusive and equitable future.
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subjects | Africa Black People - genetics capacity building community engagement DNA, Ancient - analysis genetics research Genetics, Population Genomics Humans population history |
title | Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa |
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