Fibroblast activation protein (FAP) as a prognostic biomarker in multiple tumors and its therapeutic potential in head and neck squamous cell carcinoma

Fibroblast activation protein (FAP), a cell surface serine protease, plays roles in tumor invasion and immune regulation. However, there is currently no pan-cancer analysis of FAP. We aimed to assess the pan-cancer expression profile of FAP, its molecular function, and its potential role in head and...

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Veröffentlicht in:	Oncology research 2024-01, Vol.32 (8), p.1323-1334
Hauptverfasser:	Li, Ruifang, Nan, Xinrong, Li, Ming, Rahhal, Omar
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Movement Cell Proliferation Endopeptidases - genetics Gelatinases - genetics Gelatinases - metabolism Gene Expression Regulation, Neoplastic Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Neoplasm Invasiveness Prognosis Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Signal Transduction Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - immunology Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - pathology
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