Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial
Introduction Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of th...
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| Veröffentlicht in: | International urology and nephrology 2024-08, Vol.56 (8), p.2671-2682 |
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| creator | Nataraj, Megha Maiya, G. Arun Nagaraju, Shankar Prasad Shastry, B. A. Shivashankara, K. N. Shetty, Sahana Mayya, Shreemathi S. |
| description | Introduction
Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy.
Methods
A total of 283 individuals were screened and 60 eligible participants aged 45–70 years with diabetic nephropathy were randomly allocated (
n
= 30 each) to the intervention group (IG) and control group (CG), respectively. The study outcome measures comprised of functional capacity (6-min walk test) and renal function assessed at baseline, 12th week and 24th week. Participants allocated to IG received 12 weeks of exercise based rehabilitation (comprising of supervised + home-based exercises) along with standard care and followed-up till 24th week.
Results
The repeated measures ANOVA with Greenhouse–Geisser correction indicated significant timepoint*group interaction effect for 6-min walk distance F
(1.71, 90.59)
= 619,
p
|
| doi_str_mv | 10.1007/s11255-024-03987-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11266411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3083764836</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-dcaa9f7e113aff9d9edeffc47b90dffeab048c344e567ee3260e8d6d704768033</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxi1ERcvCC3BAlrhwCTixYydcEKrKH6lSL-VsTZxx4yqJg-2wLO_Cu-Jl21I4VLLkkeebb2b8I-RFyd6UjKm3sSyrui5YJQrG20YV20fkpKwVL6q6EY_vxcfkaYzXjLG2YewJOeaNaLji9Qn5dWYtmkS9pfgDg3ERiw4i9jTgAJ0bXYLk_Ezzsets9jGM1MACxqUdhXmv3D_dZqmbadotSCvaO-gwYaQTjtlojXTr0kBnXIbgF0jD7h0FGrKHn9zP3NP4OQU_jjlMwcH4jBxZGCM-v7k35OvHs8vTz8X5xacvpx_OCyMqmYreALRWYVlysLbtW-zRWiNU17I-7wcdE43hQmAtFSKvJMOml71iQsmGcb4h7w--y9pN2BvMY8Col-AmCDvtwel_M7Mb9JX_rjMBKUXuuyGvbxyC_7ZiTHpy0eS1YUa_Rl21dVO1UimWpa_-k177NeQvjJqzjEVmNjKrqoPKBB9jQHs3Tcn0Hr8-4NcZv_6DX29z0cv7e9yV3PLOAn4QxJyarzD87f2A7W_zFcEs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3083764836</pqid></control><display><type>article</type><title>Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Nataraj, Megha ; Maiya, G. Arun ; Nagaraju, Shankar Prasad ; Shastry, B. A. ; Shivashankara, K. N. ; Shetty, Sahana ; Mayya, Shreemathi S.</creator><creatorcontrib>Nataraj, Megha ; Maiya, G. Arun ; Nagaraju, Shankar Prasad ; Shastry, B. A. ; Shivashankara, K. N. ; Shetty, Sahana ; Mayya, Shreemathi S.</creatorcontrib><description>Introduction
Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy.
Methods
A total of 283 individuals were screened and 60 eligible participants aged 45–70 years with diabetic nephropathy were randomly allocated (
n
= 30 each) to the intervention group (IG) and control group (CG), respectively. The study outcome measures comprised of functional capacity (6-min walk test) and renal function assessed at baseline, 12th week and 24th week. Participants allocated to IG received 12 weeks of exercise based rehabilitation (comprising of supervised + home-based exercises) along with standard care and followed-up till 24th week.
Results
The repeated measures ANOVA with Greenhouse–Geisser correction indicated significant timepoint*group interaction effect for 6-min walk distance F
(1.71, 90.59)
= 619,
p
< 0.001, serum creatinine F
(1.23, 65.14)
= 174.8,
p
< 0.001, estimated glomerular filtration rate
F
(1.15, 60.88)
= 105.2,
p
< 0.001, serum urea
F
(1.48, 78.45)
= 261.4,
p
< 0.001 and urine protein F
(1.13, 59.82)
= 4.58,
p
< 0.328.
Conclusion
The study found that exercise based rehabilitation improved both functional capacity and renal function among individuals with type 2 diabetic nephropathy.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-024-03987-w</identifier><identifier>PMID: 38483735</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged ; Creatinine ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - rehabilitation ; Diabetic nephropathy ; Exercise Therapy - methods ; Female ; Glomerular Filtration Rate ; Humans ; Immunoglobulins ; Kidney - physiopathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Nephrology - Original Paper ; Nephropathy ; Public health ; Rehabilitation ; Renal function ; Urology ; Well being</subject><ispartof>International urology and nephrology, 2024-08, Vol.56 (8), p.2671-2682</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-dcaa9f7e113aff9d9edeffc47b90dffeab048c344e567ee3260e8d6d704768033</cites><orcidid>0000-0002-3686-851X ; 0000-0003-0753-9490 ; 0000-0001-9473-0474 ; 0000-0002-2105-0846 ; 0000-0003-1016-8280 ; 0000-0001-7573-0137 ; 0000-0003-0851-0411</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-024-03987-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-024-03987-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38483735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nataraj, Megha</creatorcontrib><creatorcontrib>Maiya, G. Arun</creatorcontrib><creatorcontrib>Nagaraju, Shankar Prasad</creatorcontrib><creatorcontrib>Shastry, B. A.</creatorcontrib><creatorcontrib>Shivashankara, K. N.</creatorcontrib><creatorcontrib>Shetty, Sahana</creatorcontrib><creatorcontrib>Mayya, Shreemathi S.</creatorcontrib><title>Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Introduction
Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy.
Methods
A total of 283 individuals were screened and 60 eligible participants aged 45–70 years with diabetic nephropathy were randomly allocated (
n
= 30 each) to the intervention group (IG) and control group (CG), respectively. The study outcome measures comprised of functional capacity (6-min walk test) and renal function assessed at baseline, 12th week and 24th week. Participants allocated to IG received 12 weeks of exercise based rehabilitation (comprising of supervised + home-based exercises) along with standard care and followed-up till 24th week.
Results
The repeated measures ANOVA with Greenhouse–Geisser correction indicated significant timepoint*group interaction effect for 6-min walk distance F
(1.71, 90.59)
= 619,
p
< 0.001, serum creatinine F
(1.23, 65.14)
= 174.8,
p
< 0.001, estimated glomerular filtration rate
F
(1.15, 60.88)
= 105.2,
p
< 0.001, serum urea
F
(1.48, 78.45)
= 261.4,
p
< 0.001 and urine protein F
(1.13, 59.82)
= 4.58,
p
< 0.328.
Conclusion
The study found that exercise based rehabilitation improved both functional capacity and renal function among individuals with type 2 diabetic nephropathy.</description><subject>Aged</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Nephropathies - rehabilitation</subject><subject>Diabetic nephropathy</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Kidney - physiopathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Nephropathy</subject><subject>Public health</subject><subject>Rehabilitation</subject><subject>Renal function</subject><subject>Urology</subject><subject>Well being</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi1ERcvCC3BAlrhwCTixYydcEKrKH6lSL-VsTZxx4yqJg-2wLO_Cu-Jl21I4VLLkkeebb2b8I-RFyd6UjKm3sSyrui5YJQrG20YV20fkpKwVL6q6EY_vxcfkaYzXjLG2YewJOeaNaLji9Qn5dWYtmkS9pfgDg3ERiw4i9jTgAJ0bXYLk_Ezzsets9jGM1MACxqUdhXmv3D_dZqmbadotSCvaO-gwYaQTjtlojXTr0kBnXIbgF0jD7h0FGrKHn9zP3NP4OQU_jjlMwcH4jBxZGCM-v7k35OvHs8vTz8X5xacvpx_OCyMqmYreALRWYVlysLbtW-zRWiNU17I-7wcdE43hQmAtFSKvJMOml71iQsmGcb4h7w--y9pN2BvMY8Col-AmCDvtwel_M7Mb9JX_rjMBKUXuuyGvbxyC_7ZiTHpy0eS1YUa_Rl21dVO1UimWpa_-k177NeQvjJqzjEVmNjKrqoPKBB9jQHs3Tcn0Hr8-4NcZv_6DX29z0cv7e9yV3PLOAn4QxJyarzD87f2A7W_zFcEs</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Nataraj, Megha</creator><creator>Maiya, G. Arun</creator><creator>Nagaraju, Shankar Prasad</creator><creator>Shastry, B. A.</creator><creator>Shivashankara, K. N.</creator><creator>Shetty, Sahana</creator><creator>Mayya, Shreemathi S.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3686-851X</orcidid><orcidid>https://orcid.org/0000-0003-0753-9490</orcidid><orcidid>https://orcid.org/0000-0001-9473-0474</orcidid><orcidid>https://orcid.org/0000-0002-2105-0846</orcidid><orcidid>https://orcid.org/0000-0003-1016-8280</orcidid><orcidid>https://orcid.org/0000-0001-7573-0137</orcidid><orcidid>https://orcid.org/0000-0003-0851-0411</orcidid></search><sort><creationdate>20240801</creationdate><title>Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial</title><author>Nataraj, Megha ; Maiya, G. Arun ; Nagaraju, Shankar Prasad ; Shastry, B. A. ; Shivashankara, K. N. ; Shetty, Sahana ; Mayya, Shreemathi S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-dcaa9f7e113aff9d9edeffc47b90dffeab048c344e567ee3260e8d6d704768033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Nephropathies - rehabilitation</topic><topic>Diabetic nephropathy</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Kidney - physiopathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Nephropathy</topic><topic>Public health</topic><topic>Rehabilitation</topic><topic>Renal function</topic><topic>Urology</topic><topic>Well being</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nataraj, Megha</creatorcontrib><creatorcontrib>Maiya, G. Arun</creatorcontrib><creatorcontrib>Nagaraju, Shankar Prasad</creatorcontrib><creatorcontrib>Shastry, B. A.</creatorcontrib><creatorcontrib>Shivashankara, K. N.</creatorcontrib><creatorcontrib>Shetty, Sahana</creatorcontrib><creatorcontrib>Mayya, Shreemathi S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nataraj, Megha</au><au>Maiya, G. Arun</au><au>Nagaraju, Shankar Prasad</au><au>Shastry, B. A.</au><au>Shivashankara, K. N.</au><au>Shetty, Sahana</au><au>Mayya, Shreemathi S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>56</volume><issue>8</issue><spage>2671</spage><epage>2682</epage><pages>2671-2682</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Introduction
Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy.
Methods
A total of 283 individuals were screened and 60 eligible participants aged 45–70 years with diabetic nephropathy were randomly allocated (
n
= 30 each) to the intervention group (IG) and control group (CG), respectively. The study outcome measures comprised of functional capacity (6-min walk test) and renal function assessed at baseline, 12th week and 24th week. Participants allocated to IG received 12 weeks of exercise based rehabilitation (comprising of supervised + home-based exercises) along with standard care and followed-up till 24th week.
Results
The repeated measures ANOVA with Greenhouse–Geisser correction indicated significant timepoint*group interaction effect for 6-min walk distance F
(1.71, 90.59)
= 619,
p
< 0.001, serum creatinine F
(1.23, 65.14)
= 174.8,
p
< 0.001, estimated glomerular filtration rate
F
(1.15, 60.88)
= 105.2,
p
< 0.001, serum urea
F
(1.48, 78.45)
= 261.4,
p
< 0.001 and urine protein F
(1.13, 59.82)
= 4.58,
p
< 0.328.
Conclusion
The study found that exercise based rehabilitation improved both functional capacity and renal function among individuals with type 2 diabetic nephropathy.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38483735</pmid><doi>10.1007/s11255-024-03987-w</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3686-851X</orcidid><orcidid>https://orcid.org/0000-0003-0753-9490</orcidid><orcidid>https://orcid.org/0000-0001-9473-0474</orcidid><orcidid>https://orcid.org/0000-0002-2105-0846</orcidid><orcidid>https://orcid.org/0000-0003-1016-8280</orcidid><orcidid>https://orcid.org/0000-0001-7573-0137</orcidid><orcidid>https://orcid.org/0000-0003-0851-0411</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11266411 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Creatinine Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetic Nephropathies - physiopathology Diabetic Nephropathies - rehabilitation Diabetic nephropathy Exercise Therapy - methods Female Glomerular Filtration Rate Humans Immunoglobulins Kidney - physiopathology Male Medicine Medicine & Public Health Middle Aged Nephrology Nephrology - Original Paper Nephropathy Public health Rehabilitation Renal function Urology Well being |
| title | Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial |
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