End-to-side neurorrhaphy in the reconstruction of peripheral segmental neural loss: an experimental study
To evaluate the effects on peripheral neural regeneration of the end-to-side embracing repair technique compared to the autograft repair technique in Wistar rats. Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA), and embracin...
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| Veröffentlicht in: | Acta Cirúrgica Brasileira 2024-01, Vol.39, p.e394024 |
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| creator | Lemos, Rafael Silva Bentes, Livia Guerreiro de Barros Vasconcelos, Maria Eduarda Dos Santos Lopes Tramontin, Daniela Ferreira Costa, Luís Vinícius Pires da Pimentel, Antonio Leonardo Jatahi Cavalcanti Araújo, Nayara Pontes de Andrade, Mariseth Carvalho de Somensi, Danusa Neves Barros, Rui Sérgio Monteiro de |
| description | To evaluate the effects on peripheral neural regeneration of the end-to-side embracing repair technique compared to the autograft repair technique in Wistar rats.
Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA), and embracing group (EG). For the evaluation, the grasping test, electroneuromyography (ENMG), and muscle weight assessment were used.
Muscle weight assessment and ENMG did not show significant neural regeneration at the end of 12 weeks in the DG and GE groups, but only in GA. The grasping test showed an increase in strength between the surgery and the fourth week in all groups, and only the GA maintained this trend until the 12th week.
The present study indicates that the neural regeneration observed in the end-to-side embracing neurorrhaphy technique, in the repair of segmental neural loss, is inferior to autograft repair in Wistar rats. |
| doi_str_mv | 10.1590/acb394024 |
| format | Article |
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Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA), and embracing group (EG). For the evaluation, the grasping test, electroneuromyography (ENMG), and muscle weight assessment were used.
Muscle weight assessment and ENMG did not show significant neural regeneration at the end of 12 weeks in the DG and GE groups, but only in GA. The grasping test showed an increase in strength between the surgery and the fourth week in all groups, and only the GA maintained this trend until the 12th week.
The present study indicates that the neural regeneration observed in the end-to-side embracing neurorrhaphy technique, in the repair of segmental neural loss, is inferior to autograft repair in Wistar rats.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>DOI: 10.1590/acb394024</identifier><identifier>PMID: 39046042</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</publisher><subject>Animals ; Electromyography ; Male ; Median Nerve ; Microsurgery ; Muscle, Skeletal - innervation ; Nerve Regeneration ; Nerve Regeneration - physiology ; Neurosurgical Procedures - methods ; Original ; Peripheral Nerve Injuries - surgery ; Rats ; Rats, Wistar ; Reproducibility of Results ; Sciatic Nerve - injuries ; Sciatic Nerve - physiology ; Sciatic Nerve - surgery ; Time Factors ; Transplantation, Autologous - methods</subject><ispartof>Acta Cirúrgica Brasileira, 2024-01, Vol.39, p.e394024</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c371t-a8224731f5c7340ebc716d9adb7aa363726db53a981fc10e908064dfa3b0cfb03</cites><orcidid>0000-0002-9529-9556 ; 0000-0002-2832-5566 ; 0000-0001-9513-5589 ; 0000-0002-6257-5972 ; 0000-0002-6806-6220 ; 0000-0002-0399-4034 ; 0000-0002-4788-1672 ; 0000-0002-7095-7233 ; 0000-0002-4841-2894 ; 0000-0002-1226-5394</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262751/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262751/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39046042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lemos, Rafael Silva</creatorcontrib><creatorcontrib>Bentes, Livia Guerreiro de Barros</creatorcontrib><creatorcontrib>Vasconcelos, Maria Eduarda Dos Santos Lopes</creatorcontrib><creatorcontrib>Tramontin, Daniela Ferreira</creatorcontrib><creatorcontrib>Costa, Luís Vinícius Pires da</creatorcontrib><creatorcontrib>Pimentel, Antonio Leonardo Jatahi Cavalcanti</creatorcontrib><creatorcontrib>Araújo, Nayara Pontes de</creatorcontrib><creatorcontrib>Andrade, Mariseth Carvalho de</creatorcontrib><creatorcontrib>Somensi, Danusa Neves</creatorcontrib><creatorcontrib>Barros, Rui Sérgio Monteiro de</creatorcontrib><title>End-to-side neurorrhaphy in the reconstruction of peripheral segmental neural loss: an experimental study</title><title>Acta Cirúrgica Brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To evaluate the effects on peripheral neural regeneration of the end-to-side embracing repair technique compared to the autograft repair technique in Wistar rats.
Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA), and embracing group (EG). For the evaluation, the grasping test, electroneuromyography (ENMG), and muscle weight assessment were used.
Muscle weight assessment and ENMG did not show significant neural regeneration at the end of 12 weeks in the DG and GE groups, but only in GA. The grasping test showed an increase in strength between the surgery and the fourth week in all groups, and only the GA maintained this trend until the 12th week.
The present study indicates that the neural regeneration observed in the end-to-side embracing neurorrhaphy technique, in the repair of segmental neural loss, is inferior to autograft repair in Wistar rats.</description><subject>Animals</subject><subject>Electromyography</subject><subject>Male</subject><subject>Median Nerve</subject><subject>Microsurgery</subject><subject>Muscle, Skeletal - innervation</subject><subject>Nerve Regeneration</subject><subject>Nerve Regeneration - physiology</subject><subject>Neurosurgical Procedures - methods</subject><subject>Original</subject><subject>Peripheral Nerve Injuries - surgery</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproducibility of Results</subject><subject>Sciatic Nerve - injuries</subject><subject>Sciatic Nerve - physiology</subject><subject>Sciatic Nerve - surgery</subject><subject>Time Factors</subject><subject>Transplantation, Autologous - methods</subject><issn>0102-8650</issn><issn>1678-2674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVkcFO3DAQhq2qqCy0h75A5WsPoTO2Yye9VAjRFgmJS3u2JrazCVriyM4i9u3xdukKTjOa-ecbj3_GPiNcYN3CN3KdbBUI9Y6tUJumEtqo92wFCKJqdA2n7CznewBUGuUHdipbUBqUWLHxevLVEqs8-sCnsE0xpYHmYcfHiS9D4Cm4OOUlbd0yxonHns8hjfMQEm14DuuHMC0l24-WsIk5f-c08fC0l70087L1u4_spKdNDp9e4jn7-_P6z9Xv6vbu183V5W3lpMGlokYIZST2tTNSQeicQe1b8p0hkloaoX1XS2ob7B1CaKEBrXxPsgPXdyDP2c2B6yPd27k8gtLORhrtv0JMa0tpGd0m2Fp7pZSXovdCaRM6RVCjaQV5bGrpCuvHgTVvu4fgXTmnXPkG-rYzjYNdx0eLKLQwNRbC1wPBpfI1KfTHYQS7N88ezSvaL6-3HZX_3ZLPBZ6Xeg</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Lemos, Rafael Silva</creator><creator>Bentes, Livia Guerreiro de Barros</creator><creator>Vasconcelos, Maria Eduarda Dos Santos Lopes</creator><creator>Tramontin, Daniela Ferreira</creator><creator>Costa, Luís Vinícius Pires da</creator><creator>Pimentel, Antonio Leonardo Jatahi Cavalcanti</creator><creator>Araújo, Nayara Pontes de</creator><creator>Andrade, Mariseth Carvalho de</creator><creator>Somensi, Danusa Neves</creator><creator>Barros, Rui Sérgio Monteiro de</creator><general>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9529-9556</orcidid><orcidid>https://orcid.org/0000-0002-2832-5566</orcidid><orcidid>https://orcid.org/0000-0001-9513-5589</orcidid><orcidid>https://orcid.org/0000-0002-6257-5972</orcidid><orcidid>https://orcid.org/0000-0002-6806-6220</orcidid><orcidid>https://orcid.org/0000-0002-0399-4034</orcidid><orcidid>https://orcid.org/0000-0002-4788-1672</orcidid><orcidid>https://orcid.org/0000-0002-7095-7233</orcidid><orcidid>https://orcid.org/0000-0002-4841-2894</orcidid><orcidid>https://orcid.org/0000-0002-1226-5394</orcidid></search><sort><creationdate>20240101</creationdate><title>End-to-side neurorrhaphy in the reconstruction of peripheral segmental neural loss: an experimental study</title><author>Lemos, Rafael Silva ; 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Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA), and embracing group (EG). For the evaluation, the grasping test, electroneuromyography (ENMG), and muscle weight assessment were used.
Muscle weight assessment and ENMG did not show significant neural regeneration at the end of 12 weeks in the DG and GE groups, but only in GA. The grasping test showed an increase in strength between the surgery and the fourth week in all groups, and only the GA maintained this trend until the 12th week.
The present study indicates that the neural regeneration observed in the end-to-side embracing neurorrhaphy technique, in the repair of segmental neural loss, is inferior to autograft repair in Wistar rats.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia</pub><pmid>39046042</pmid><doi>10.1590/acb394024</doi><orcidid>https://orcid.org/0000-0002-9529-9556</orcidid><orcidid>https://orcid.org/0000-0002-2832-5566</orcidid><orcidid>https://orcid.org/0000-0001-9513-5589</orcidid><orcidid>https://orcid.org/0000-0002-6257-5972</orcidid><orcidid>https://orcid.org/0000-0002-6806-6220</orcidid><orcidid>https://orcid.org/0000-0002-0399-4034</orcidid><orcidid>https://orcid.org/0000-0002-4788-1672</orcidid><orcidid>https://orcid.org/0000-0002-7095-7233</orcidid><orcidid>https://orcid.org/0000-0002-4841-2894</orcidid><orcidid>https://orcid.org/0000-0002-1226-5394</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Electromyography Male Median Nerve Microsurgery Muscle, Skeletal - innervation Nerve Regeneration Nerve Regeneration - physiology Neurosurgical Procedures - methods Original Peripheral Nerve Injuries - surgery Rats Rats, Wistar Reproducibility of Results Sciatic Nerve - injuries Sciatic Nerve - physiology Sciatic Nerve - surgery Time Factors Transplantation, Autologous - methods |
| title | End-to-side neurorrhaphy in the reconstruction of peripheral segmental neural loss: an experimental study |
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