Lung decellularized matrix-derived 3D spheroids: Exploring silicosis through the impact of the Nrf2/Bax pathway on myofibroblast dynamics

Silicosis is an occupational respiratory disease caused by long-term inhalation of high concentrations of free silica particles. Studies suggest that oxidative stress is a crucial initiator of silicosis fibrosis, and previous studies have linked the antioxidative stress transcription factor known as...

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Veröffentlicht in:	Heliyon 2024-07, Vol.10 (13), p.e33585, Article e33585
Hauptverfasser:	Xue, Wenming, Wang, Jiaxin, Hou, Yao, Wu, Di, Wang, Hongwei, Jia, Qiyue, Jiang, Qiyue, Wang, Yan, Song, Chenzhao, Wang, Yifei, Zhu, Zhonghui, Tian, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	3D culture antagonism Apoptosis breathing cell culture collagen fibroblasts Fibrosis fluorescent antibody technique lungs mechanism of action Myofibroblasts Nrf2 oxidative stress phenotype respiratory tract diseases Silica therapeutics transcription factors Western blotting
Online-Zugang:	Volltext
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