Three Cases of Serous Tubal Intraepithelial Lesions (STILs)
Serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesions (STILs), and the p53 signature are considered to be related to precursor lesions of high-grade serous carcinomas (HGSCs). However, the clinical significance and prognostic implications of these lesion types are currently un...
Gespeichert in:
| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-06, Vol.16 (6), p.e62895 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | e62895 |
| container_title | Curēus (Palo Alto, CA) |
| container_volume | 16 |
| creator | Mizuno, Mika Togami, Shinichi Shirota, Kyoko Kitazono, Ikumi Kobayashi, Hiroaki |
| description | Serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesions (STILs), and the p53 signature are considered to be related to precursor lesions of high-grade serous carcinomas (HGSCs). However, the clinical significance and prognostic implications of these lesion types are currently unknown. We diagnosed three patients with STILs according to the morphological evaluation criteria and combined this with p53 and Ki-67 immunostaining. One patient had an HGSC of the ovary that was incidentally discovered at the time of ovarian cyst resection, and the HGSC in the other two patients was characterized after they underwent risk-reducing salpingo-oophorectomy. Herein, we present a report of three patients with STILs diagnosed based on clinical data and pathological findings, along with a review of the literature. |
| doi_str_mv | 10.7759/cureus.62895 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11261535</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3086794729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-f4f425dfea58d40df880cdd926e37945acf4e6112c0440d989813e7a373378173</originalsourceid><addsrcrecordid>eNpdkc1Lw0AQxRdRbKm9eZaAFwVTZ7NJdhcPIsWPQsBD43nZbiY2JU3qbiP437u1tVRPM8P8eLzHI-ScwojzRN6azmLnRmkkZHJE-hFNRSioiI8P9h4ZOrcAAAo8Ag6npMckxMAF75O7fG4Rg7F26IK2DKZo284FeTfTdTBp1lbjqlrPsa78naGr2sYFV9N8krnrM3JS6trhcDcH5O3pMR-_hNnr82T8kIWGAazDMi7jKClK1IkoYihKIcAUhYxSZFzGiTZljCmlkYHYv6WQgjLkmnHGuKCcDcj9VnfVzZZYGNzYqtXKVkttv1SrK_X301Rz9d5-Kq-Z0oQlXuFqp2Dbjw7dWi0rZ7CudYM-rmIgWCoiSKhHL_-hi7azjc-3oVJvmEfSUzdbytjWOYvl3g0FtWlGbZtRP814_OIwwR7-7YF9A-6KiL4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3086794729</pqid></control><display><type>article</type><title>Three Cases of Serous Tubal Intraepithelial Lesions (STILs)</title><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Mizuno, Mika ; Togami, Shinichi ; Shirota, Kyoko ; Kitazono, Ikumi ; Kobayashi, Hiroaki</creator><creatorcontrib>Mizuno, Mika ; Togami, Shinichi ; Shirota, Kyoko ; Kitazono, Ikumi ; Kobayashi, Hiroaki</creatorcontrib><description>Serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesions (STILs), and the p53 signature are considered to be related to precursor lesions of high-grade serous carcinomas (HGSCs). However, the clinical significance and prognostic implications of these lesion types are currently unknown. We diagnosed three patients with STILs according to the morphological evaluation criteria and combined this with p53 and Ki-67 immunostaining. One patient had an HGSC of the ovary that was incidentally discovered at the time of ovarian cyst resection, and the HGSC in the other two patients was characterized after they underwent risk-reducing salpingo-oophorectomy. Herein, we present a report of three patients with STILs diagnosed based on clinical data and pathological findings, along with a review of the literature.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.62895</identifier><identifier>PMID: 39040787</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Breast cancer ; Cancer therapies ; Cellular biology ; Chemotherapy ; Cloning ; Cysts ; Epidermal growth factor ; Fallopian tubes ; Laparoscopy ; Lung cancer ; Magnetic resonance imaging ; Morphology ; Obstetrics/Gynecology ; Oncology ; Ovarian cancer ; Pathology ; Patients ; Tumors</subject><ispartof>Curēus (Palo Alto, CA), 2024-06, Vol.16 (6), p.e62895</ispartof><rights>Copyright © 2024, Mizuno et al.</rights><rights>Copyright © 2024, Mizuno et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024, Mizuno et al. 2024 Mizuno et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-f4f425dfea58d40df880cdd926e37945acf4e6112c0440d989813e7a373378173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261535/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261535/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39040787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizuno, Mika</creatorcontrib><creatorcontrib>Togami, Shinichi</creatorcontrib><creatorcontrib>Shirota, Kyoko</creatorcontrib><creatorcontrib>Kitazono, Ikumi</creatorcontrib><creatorcontrib>Kobayashi, Hiroaki</creatorcontrib><title>Three Cases of Serous Tubal Intraepithelial Lesions (STILs)</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesions (STILs), and the p53 signature are considered to be related to precursor lesions of high-grade serous carcinomas (HGSCs). However, the clinical significance and prognostic implications of these lesion types are currently unknown. We diagnosed three patients with STILs according to the morphological evaluation criteria and combined this with p53 and Ki-67 immunostaining. One patient had an HGSC of the ovary that was incidentally discovered at the time of ovarian cyst resection, and the HGSC in the other two patients was characterized after they underwent risk-reducing salpingo-oophorectomy. Herein, we present a report of three patients with STILs diagnosed based on clinical data and pathological findings, along with a review of the literature.</description><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Cellular biology</subject><subject>Chemotherapy</subject><subject>Cloning</subject><subject>Cysts</subject><subject>Epidermal growth factor</subject><subject>Fallopian tubes</subject><subject>Laparoscopy</subject><subject>Lung cancer</subject><subject>Magnetic resonance imaging</subject><subject>Morphology</subject><subject>Obstetrics/Gynecology</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><subject>Pathology</subject><subject>Patients</subject><subject>Tumors</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkc1Lw0AQxRdRbKm9eZaAFwVTZ7NJdhcPIsWPQsBD43nZbiY2JU3qbiP437u1tVRPM8P8eLzHI-ScwojzRN6azmLnRmkkZHJE-hFNRSioiI8P9h4ZOrcAAAo8Ag6npMckxMAF75O7fG4Rg7F26IK2DKZo284FeTfTdTBp1lbjqlrPsa78naGr2sYFV9N8krnrM3JS6trhcDcH5O3pMR-_hNnr82T8kIWGAazDMi7jKClK1IkoYihKIcAUhYxSZFzGiTZljCmlkYHYv6WQgjLkmnHGuKCcDcj9VnfVzZZYGNzYqtXKVkttv1SrK_X301Rz9d5-Kq-Z0oQlXuFqp2Dbjw7dWi0rZ7CudYM-rmIgWCoiSKhHL_-hi7azjc-3oVJvmEfSUzdbytjWOYvl3g0FtWlGbZtRP814_OIwwR7-7YF9A-6KiL4</recordid><startdate>20240622</startdate><enddate>20240622</enddate><creator>Mizuno, Mika</creator><creator>Togami, Shinichi</creator><creator>Shirota, Kyoko</creator><creator>Kitazono, Ikumi</creator><creator>Kobayashi, Hiroaki</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240622</creationdate><title>Three Cases of Serous Tubal Intraepithelial Lesions (STILs)</title><author>Mizuno, Mika ; Togami, Shinichi ; Shirota, Kyoko ; Kitazono, Ikumi ; Kobayashi, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-f4f425dfea58d40df880cdd926e37945acf4e6112c0440d989813e7a373378173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Cellular biology</topic><topic>Chemotherapy</topic><topic>Cloning</topic><topic>Cysts</topic><topic>Epidermal growth factor</topic><topic>Fallopian tubes</topic><topic>Laparoscopy</topic><topic>Lung cancer</topic><topic>Magnetic resonance imaging</topic><topic>Morphology</topic><topic>Obstetrics/Gynecology</topic><topic>Oncology</topic><topic>Ovarian cancer</topic><topic>Pathology</topic><topic>Patients</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizuno, Mika</creatorcontrib><creatorcontrib>Togami, Shinichi</creatorcontrib><creatorcontrib>Shirota, Kyoko</creatorcontrib><creatorcontrib>Kitazono, Ikumi</creatorcontrib><creatorcontrib>Kobayashi, Hiroaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizuno, Mika</au><au>Togami, Shinichi</au><au>Shirota, Kyoko</au><au>Kitazono, Ikumi</au><au>Kobayashi, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three Cases of Serous Tubal Intraepithelial Lesions (STILs)</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-06-22</date><risdate>2024</risdate><volume>16</volume><issue>6</issue><spage>e62895</spage><pages>e62895-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesions (STILs), and the p53 signature are considered to be related to precursor lesions of high-grade serous carcinomas (HGSCs). However, the clinical significance and prognostic implications of these lesion types are currently unknown. We diagnosed three patients with STILs according to the morphological evaluation criteria and combined this with p53 and Ki-67 immunostaining. One patient had an HGSC of the ovary that was incidentally discovered at the time of ovarian cyst resection, and the HGSC in the other two patients was characterized after they underwent risk-reducing salpingo-oophorectomy. Herein, we present a report of three patients with STILs diagnosed based on clinical data and pathological findings, along with a review of the literature.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>39040787</pmid><doi>10.7759/cureus.62895</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-8184 |
| ispartof | Curēus (Palo Alto, CA), 2024-06, Vol.16 (6), p.e62895 |
| issn | 2168-8184 2168-8184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11261535 |
| source | PubMed Central; PubMed Central Open Access |
| subjects | Breast cancer Cancer therapies Cellular biology Chemotherapy Cloning Cysts Epidermal growth factor Fallopian tubes Laparoscopy Lung cancer Magnetic resonance imaging Morphology Obstetrics/Gynecology Oncology Ovarian cancer Pathology Patients Tumors |
| title | Three Cases of Serous Tubal Intraepithelial Lesions (STILs) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T12%3A34%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Three%20Cases%20of%20Serous%20Tubal%20Intraepithelial%20Lesions%20(STILs)&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Mizuno,%20Mika&rft.date=2024-06-22&rft.volume=16&rft.issue=6&rft.spage=e62895&rft.pages=e62895-&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.62895&rft_dat=%3Cproquest_pubme%3E3086794729%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3086794729&rft_id=info:pmid/39040787&rfr_iscdi=true |