KDM6A–SND1 interaction maintains genomic stability by protecting the nascent DNA and contributes to cancer chemoresistance

Abstract Genomic instability is one of the hallmarks of cancer. While loss of histone demethylase KDM6A increases the risk of tumorigenesis, its specific role in maintaining genomic stability remains poorly understood. Here, we propose a mechanism in which KDM6A maintains genomic stability independe...

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Veröffentlicht in:	Nucleic acids research 2024-07, Vol.52 (13), p.7665-7686
Hauptverfasser:	Wu, Jian, Jiang, Yixin, Zhang, Qin, Mao, Xiaobing, Wu, Tong, Hao, Mengqiu, Zhang, Su, Meng, Yang, Wan, Xiaowen, Qiu, Lei, Han, Junhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chromatin - genetics Chromatin - metabolism DNA Replication Drug Resistance, Neoplasm - genetics Endonucleases - genetics Endonucleases - metabolism Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Genome Integrity, Repair and Genomic Instability - genetics Histone Demethylases - genetics Histone Demethylases - metabolism Histones - metabolism Humans Ku Autoantigen - genetics Ku Autoantigen - metabolism Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Sumoylation
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