Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies

Abstract Background Early assessment of antibody off-target binding is essential for mitigating developability risks such as fast clearance, reduced efficacy, toxicity, and immunogenicity. The baculovirus particle (BVP) binding assay has been widely utilized to evaluate polyreactivity of antibodies....

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Veröffentlicht in:	Antibody therapeutics 2024-07, Vol.7 (3), p.199-208
Hauptverfasser:	Yu, Xin, Vangjeli, Kostika, Prakash, Anusha, Chhaya, Meha, Stanley, Samantha J, Cohen, Noah, Huang, Lili
Format:	Artikel
Sprache:	eng
Schlagworte:	Artificial Intelligence in antibody discovery, development and beyond
Online-Zugang:	Volltext
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