Dynamic interchange between two protonation states is characteristic of active sites of cholinesterases

Cholinesterases are well‐known and widely studied enzymes crucial to human health and involved in neurology, Alzheimer's, and lipid metabolism. The protonation pattern of active sites of cholinesterases influences all the chemical processes within, including reaction, covalent inhibition by ner...

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Veröffentlicht in:Protein science 2024-08, Vol.33 (8), p.e5100-n/a
Hauptverfasser: Zlobin, Alexander, Smirnov, Ivan, Golovin, Andrey
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Sprache:eng
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