Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study
Abstract Background Frailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans. Methods We developed a questionnaire-based deficit accumulation frailty index (FI) in the Multiethnic Cohort (MEC) and examined frailty status (robust, FI 0 to
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2023-07, Vol.78 (7), p.1246-1257 |
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| creator | Wu, Anna H Setiawan, V Wendy Stram, Daniel O Crimmins, Eileen M Tseng, Chiu-Chen Lim, Unhee Park, Song-Yi White, Kami K Cheng, Iona Haiman, Christopher A Wilkens, Lynne R Le Marchand, Loïc |
| description | Abstract
Background
Frailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans.
Methods
We developed a questionnaire-based deficit accumulation frailty index (FI) in the Multiethnic Cohort (MEC) and examined frailty status (robust, FI 0 to |
| doi_str_mv | 10.1093/gerona/glac216 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11255091</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/gerona/glac216</oup_id><sourcerecordid>2840800126</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-df9a286439fb95bf4f04d0bbdfd024cd228f8009a3e2211080870d96be8443093</originalsourceid><addsrcrecordid>eNqFkctrVDEUhy-i2IduXUrAjYXeNslN7uSupExbLVSEtoK7kJvHTEpuMs1DnP_eTGcs1o3ZJJDvfJxzfk3zDsETBIfudKFj8OJ04YTEqH_R7KMZZS3t6I-X9Q1nQ0sh7Peag5Tu4eZQ_LrZ63pMaa3fb8qNkFa4Y3CRl97KYyC8ArdB2qBl8GGyEpxbY3TUXuoErAcCnGtjpc3gTMoyFSeyDR5cRmFdXoMrr_SvDZeXGnwtLlv9aAbzsAwxg9tc1PpN88oIl_Tb3X3YfL-8uJt_aa-_fb6an123ktAut8oMArOedIMZBzoaYiBRcByVURATqTBmhkE4iE5jjBBkkM2gGvpRM0K6up7D5tPWuyrjpJXUPkfh-CraScQ1D8Ly5z_eLvki_OQI1QXBAVXDx50hhoeiU-aTTVI7J7wOJXE8w7SnHcGsoh_-Qe9Dib7OxzEjtTmIcF-pky0lY0gpavPUDYJ8EynfRsp3kdaC93_P8IT_ybACR1sglNX_ZL8Bd--t7A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2840800126</pqid></control><display><type>article</type><title>Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>Sociological Abstracts</source><creator>Wu, Anna H ; Setiawan, V Wendy ; Stram, Daniel O ; Crimmins, Eileen M ; Tseng, Chiu-Chen ; Lim, Unhee ; Park, Song-Yi ; White, Kami K ; Cheng, Iona ; Haiman, Christopher A ; Wilkens, Lynne R ; Le Marchand, Loïc</creator><creatorcontrib>Wu, Anna H ; Setiawan, V Wendy ; Stram, Daniel O ; Crimmins, Eileen M ; Tseng, Chiu-Chen ; Lim, Unhee ; Park, Song-Yi ; White, Kami K ; Cheng, Iona ; Haiman, Christopher A ; Wilkens, Lynne R ; Le Marchand, Loïc</creatorcontrib><description>Abstract
Background
Frailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans.
Methods
We developed a questionnaire-based deficit accumulation frailty index (FI) in the Multiethnic Cohort (MEC) and examined frailty status (robust, FI 0 to <0.2, prefrail, FI 0.2 to <0.35, and frail FI ≥ 0.35) among 29 026 men and 40 756 women.
Results
After adjustment for age, demographic, lifestyle factors, and chronic conditions, relative to White men, odds of being frail was significantly higher (34%–54%) among African American, Native Hawaiian, and other Asian American men, whereas odds was significantly lower (36%) in Japanese American men and did not differ in Latino men. However, among men who had high school or less, none of the groups displayed significantly higher odds of prefrail or frail compared with White men. Relative to White women, odds of being frail were significantly higher (14%–33%) in African American and Latino women, did not differ for other Asian American women and lower (14%–36%) in Native Hawaiian and Japanese American women. These racial and ethnic differences in women were observed irrespective of education. Risk of all-cause mortality was higher in prefrail and frail men than robust men (adjusted hazard ratio [HR] = 1.69, 1.59–1.81; HR = 3.27, 3.03–3.53); results were similar in women. All-cause mortality was significantly positively associated with frailty status and frailty score across all sex, race, and ethnic groups,
Conclusions
Frailty status differed significantly by race and ethnicity and was consistently associated with all-cause mortality. The FI may be a useful tool for aging studies in this multiethnic population.</description><identifier>ISSN: 1079-5006</identifier><identifier>ISSN: 1758-535X</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glac216</identifier><identifier>PMID: 36255109</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Asian American Native Hawaiian and Pacific Islander ; Asian Americans ; Black or African American ; Chronic illnesses ; Cohort analysis ; Cohort Studies ; Educational Status ; Ethnic groups ; Ethnicity ; Female ; Frailty ; Gender differences ; Gerontology ; Hispanic Americans ; Hispanic or Latino ; Humans ; Indexes ; Male ; Men ; Minority & ethnic groups ; Mortality ; Population studies ; Race ; Racial differences ; Socioeconomic factors ; THE JOURNAL OF GERONTOLOGY: Medical Sciences ; White ; White people ; Women</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2023-07, Vol.78 (7), p.1246-1257</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press Jul 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-df9a286439fb95bf4f04d0bbdfd024cd228f8009a3e2211080870d96be8443093</citedby><cites>FETCH-LOGICAL-c453t-df9a286439fb95bf4f04d0bbdfd024cd228f8009a3e2211080870d96be8443093</cites><orcidid>0000-0001-6221-7190 ; 0000-0003-0546-902X ; 0000-0001-7734-5320</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902,33751</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36255109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Anna H</creatorcontrib><creatorcontrib>Setiawan, V Wendy</creatorcontrib><creatorcontrib>Stram, Daniel O</creatorcontrib><creatorcontrib>Crimmins, Eileen M</creatorcontrib><creatorcontrib>Tseng, Chiu-Chen</creatorcontrib><creatorcontrib>Lim, Unhee</creatorcontrib><creatorcontrib>Park, Song-Yi</creatorcontrib><creatorcontrib>White, Kami K</creatorcontrib><creatorcontrib>Cheng, Iona</creatorcontrib><creatorcontrib>Haiman, Christopher A</creatorcontrib><creatorcontrib>Wilkens, Lynne R</creatorcontrib><creatorcontrib>Le Marchand, Loïc</creatorcontrib><title>Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Abstract
Background
Frailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans.
Methods
We developed a questionnaire-based deficit accumulation frailty index (FI) in the Multiethnic Cohort (MEC) and examined frailty status (robust, FI 0 to <0.2, prefrail, FI 0.2 to <0.35, and frail FI ≥ 0.35) among 29 026 men and 40 756 women.
Results
After adjustment for age, demographic, lifestyle factors, and chronic conditions, relative to White men, odds of being frail was significantly higher (34%–54%) among African American, Native Hawaiian, and other Asian American men, whereas odds was significantly lower (36%) in Japanese American men and did not differ in Latino men. However, among men who had high school or less, none of the groups displayed significantly higher odds of prefrail or frail compared with White men. Relative to White women, odds of being frail were significantly higher (14%–33%) in African American and Latino women, did not differ for other Asian American women and lower (14%–36%) in Native Hawaiian and Japanese American women. These racial and ethnic differences in women were observed irrespective of education. Risk of all-cause mortality was higher in prefrail and frail men than robust men (adjusted hazard ratio [HR] = 1.69, 1.59–1.81; HR = 3.27, 3.03–3.53); results were similar in women. All-cause mortality was significantly positively associated with frailty status and frailty score across all sex, race, and ethnic groups,
Conclusions
Frailty status differed significantly by race and ethnicity and was consistently associated with all-cause mortality. The FI may be a useful tool for aging studies in this multiethnic population.</description><subject>Asian American Native Hawaiian and Pacific Islander</subject><subject>Asian Americans</subject><subject>Black or African American</subject><subject>Chronic illnesses</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Educational Status</subject><subject>Ethnic groups</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Frailty</subject><subject>Gender differences</subject><subject>Gerontology</subject><subject>Hispanic Americans</subject><subject>Hispanic or Latino</subject><subject>Humans</subject><subject>Indexes</subject><subject>Male</subject><subject>Men</subject><subject>Minority & ethnic groups</subject><subject>Mortality</subject><subject>Population studies</subject><subject>Race</subject><subject>Racial differences</subject><subject>Socioeconomic factors</subject><subject>THE JOURNAL OF GERONTOLOGY: Medical Sciences</subject><subject>White</subject><subject>White people</subject><subject>Women</subject><issn>1079-5006</issn><issn>1758-535X</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BHHNA</sourceid><recordid>eNqFkctrVDEUhy-i2IduXUrAjYXeNslN7uSupExbLVSEtoK7kJvHTEpuMs1DnP_eTGcs1o3ZJJDvfJxzfk3zDsETBIfudKFj8OJ04YTEqH_R7KMZZS3t6I-X9Q1nQ0sh7Peag5Tu4eZQ_LrZ63pMaa3fb8qNkFa4Y3CRl97KYyC8ArdB2qBl8GGyEpxbY3TUXuoErAcCnGtjpc3gTMoyFSeyDR5cRmFdXoMrr_SvDZeXGnwtLlv9aAbzsAwxg9tc1PpN88oIl_Tb3X3YfL-8uJt_aa-_fb6an123ktAut8oMArOedIMZBzoaYiBRcByVURATqTBmhkE4iE5jjBBkkM2gGvpRM0K6up7D5tPWuyrjpJXUPkfh-CraScQ1D8Ly5z_eLvki_OQI1QXBAVXDx50hhoeiU-aTTVI7J7wOJXE8w7SnHcGsoh_-Qe9Dib7OxzEjtTmIcF-pky0lY0gpavPUDYJ8EynfRsp3kdaC93_P8IT_ybACR1sglNX_ZL8Bd--t7A</recordid><startdate>20230708</startdate><enddate>20230708</enddate><creator>Wu, Anna H</creator><creator>Setiawan, V Wendy</creator><creator>Stram, Daniel O</creator><creator>Crimmins, Eileen M</creator><creator>Tseng, Chiu-Chen</creator><creator>Lim, Unhee</creator><creator>Park, Song-Yi</creator><creator>White, Kami K</creator><creator>Cheng, Iona</creator><creator>Haiman, Christopher A</creator><creator>Wilkens, Lynne R</creator><creator>Le Marchand, Loïc</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U3</scope><scope>BHHNA</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6221-7190</orcidid><orcidid>https://orcid.org/0000-0003-0546-902X</orcidid><orcidid>https://orcid.org/0000-0001-7734-5320</orcidid></search><sort><creationdate>20230708</creationdate><title>Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study</title><author>Wu, Anna H ; Setiawan, V Wendy ; Stram, Daniel O ; Crimmins, Eileen M ; Tseng, Chiu-Chen ; Lim, Unhee ; Park, Song-Yi ; White, Kami K ; Cheng, Iona ; Haiman, Christopher A ; Wilkens, Lynne R ; Le Marchand, Loïc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-df9a286439fb95bf4f04d0bbdfd024cd228f8009a3e2211080870d96be8443093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Asian American Native Hawaiian and Pacific Islander</topic><topic>Asian Americans</topic><topic>Black or African American</topic><topic>Chronic illnesses</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Educational Status</topic><topic>Ethnic groups</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Frailty</topic><topic>Gender differences</topic><topic>Gerontology</topic><topic>Hispanic Americans</topic><topic>Hispanic or Latino</topic><topic>Humans</topic><topic>Indexes</topic><topic>Male</topic><topic>Men</topic><topic>Minority & ethnic groups</topic><topic>Mortality</topic><topic>Population studies</topic><topic>Race</topic><topic>Racial differences</topic><topic>Socioeconomic factors</topic><topic>THE JOURNAL OF GERONTOLOGY: Medical Sciences</topic><topic>White</topic><topic>White people</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Anna H</creatorcontrib><creatorcontrib>Setiawan, V Wendy</creatorcontrib><creatorcontrib>Stram, Daniel O</creatorcontrib><creatorcontrib>Crimmins, Eileen M</creatorcontrib><creatorcontrib>Tseng, Chiu-Chen</creatorcontrib><creatorcontrib>Lim, Unhee</creatorcontrib><creatorcontrib>Park, Song-Yi</creatorcontrib><creatorcontrib>White, Kami K</creatorcontrib><creatorcontrib>Cheng, Iona</creatorcontrib><creatorcontrib>Haiman, Christopher A</creatorcontrib><creatorcontrib>Wilkens, Lynne R</creatorcontrib><creatorcontrib>Le Marchand, Loïc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Anna H</au><au>Setiawan, V Wendy</au><au>Stram, Daniel O</au><au>Crimmins, Eileen M</au><au>Tseng, Chiu-Chen</au><au>Lim, Unhee</au><au>Park, Song-Yi</au><au>White, Kami K</au><au>Cheng, Iona</au><au>Haiman, Christopher A</au><au>Wilkens, Lynne R</au><au>Le Marchand, Loïc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2023-07-08</date><risdate>2023</risdate><volume>78</volume><issue>7</issue><spage>1246</spage><epage>1257</epage><pages>1246-1257</pages><issn>1079-5006</issn><issn>1758-535X</issn><eissn>1758-535X</eissn><abstract>Abstract
Background
Frailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans.
Methods
We developed a questionnaire-based deficit accumulation frailty index (FI) in the Multiethnic Cohort (MEC) and examined frailty status (robust, FI 0 to <0.2, prefrail, FI 0.2 to <0.35, and frail FI ≥ 0.35) among 29 026 men and 40 756 women.
Results
After adjustment for age, demographic, lifestyle factors, and chronic conditions, relative to White men, odds of being frail was significantly higher (34%–54%) among African American, Native Hawaiian, and other Asian American men, whereas odds was significantly lower (36%) in Japanese American men and did not differ in Latino men. However, among men who had high school or less, none of the groups displayed significantly higher odds of prefrail or frail compared with White men. Relative to White women, odds of being frail were significantly higher (14%–33%) in African American and Latino women, did not differ for other Asian American women and lower (14%–36%) in Native Hawaiian and Japanese American women. These racial and ethnic differences in women were observed irrespective of education. Risk of all-cause mortality was higher in prefrail and frail men than robust men (adjusted hazard ratio [HR] = 1.69, 1.59–1.81; HR = 3.27, 3.03–3.53); results were similar in women. All-cause mortality was significantly positively associated with frailty status and frailty score across all sex, race, and ethnic groups,
Conclusions
Frailty status differed significantly by race and ethnicity and was consistently associated with all-cause mortality. The FI may be a useful tool for aging studies in this multiethnic population.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>36255109</pmid><doi>10.1093/gerona/glac216</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6221-7190</orcidid><orcidid>https://orcid.org/0000-0003-0546-902X</orcidid><orcidid>https://orcid.org/0000-0001-7734-5320</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Asian American Native Hawaiian and Pacific Islander Asian Americans Black or African American Chronic illnesses Cohort analysis Cohort Studies Educational Status Ethnic groups Ethnicity Female Frailty Gender differences Gerontology Hispanic Americans Hispanic or Latino Humans Indexes Male Men Minority & ethnic groups Mortality Population studies Race Racial differences Socioeconomic factors THE JOURNAL OF GERONTOLOGY: Medical Sciences White White people Women |
| title | Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study |
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