Heavy metals in biological samples of cancer patients: a systematic literature review
The majority of the so-called heavy metals are suspected to be involved in a number of pathologies and play a role in human carcinogenesis. Some of them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) and nickel (Ni)) have been defined as carcinogens, increasing the suscepti...
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| Veröffentlicht in: | Biometals 2024-08, Vol.37 (4), p.803-817 |
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| creator | Coradduzza, Donatella Congiargiu, Antonella Azara, Emanuela Mammani, Ismaeil Mohammed Abulkahar De Miglio, Maria Rosaria Zinellu, Angelo Carru, Ciriaco Medici, Serenella |
| description | The majority of the so-called heavy metals are suspected to be involved in a number of pathologies and play a role in human carcinogenesis. Some of them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) and nickel (Ni)) have been defined as carcinogens, increasing the susceptibility of tumor development and progression in humans. Moreover, Ni, Cr, Cd, Hg, and Pb together with zinc (Zn) and iron (Fe), may be capable of stimulating the progression of breast cancer and reducing a patient’s sensitivity to treatment through alterations to DNA methylation. In patients with gastric cancers, levels of various heavy metals are augmented and hypothesized to amplify the expression of the human epidermal growth factor receptor type 2 gene. Cd may increase the risk of lung cancer development and have a negative impact on the overall survival of lung cancer patients. To investigate the relation between heavy metals in biological samples and risk, occurrence and survival cancer individuals, a comprehensive review work was performed, with a focus on breast, lung, prostate and gastric cancers. An extensive search strategy was devised to ensure relevant literature could be identified, with the PECO framework being adopted to facilitate this and identify key search terms. As evidenced in this review, there is substantial data to support the hypothesis that heavy metals influence tumor development and progression. Unluckily the number of papers dealing with the determination of metals directly in samples from cancer tissues is still rather limited, so we decided to expand the scope of this review also to analyses carried out on other biological samples, as urine, plasma, hair, nail, etc. The studies reviewed showed that several limitations and current knowledge gaps are present in the literature that require further investigation to improve our comprehension of the impact of different heavy metals on tumorigenesis.
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| doi_str_mv | 10.1007/s10534-024-00583-4 |
| format | Article |
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Graphical abstract</description><subject>Arsenic</subject><subject>Biochemistry</subject><subject>Biological properties</subject><subject>Biological samples</subject><subject>Biomedical and Life Sciences</subject><subject>Breast cancer</subject><subject>Cadmium</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cell Biology</subject><subject>Chromium</subject><subject>DNA methylation</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Heavy metals</subject><subject>Iron</subject><subject>Lead</subject><subject>Life Sciences</subject><subject>Literature reviews</subject><subject>Lung cancer</subject><subject>Medicine/Public Health</subject><subject>Mercury</subject><subject>Mercury (metal)</subject><subject>Microbiology</subject><subject>Nickel</subject><subject>Pharmacology/Toxicology</subject><subject>Plant Physiology</subject><subject>Review</subject><subject>Search methods</subject><subject>Survival</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>0966-0844</issn><issn>1572-8773</issn><issn>1572-8773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kctuFDEQRS0EIkPCD7BAltiwaSi_bTYIRYREisQmWVsed_XgqB-D3T3R_D1OJgTIgoVVkuvU9S1fQt4w-MAAzMfCQAnZAK8HlBWNfEZWTBneWGPEc7ICp3UDVsoj8qqUGwBwBvRLciSskIY7tSLX5xh2ezrgHPpC00jXaeqnTYqhpyUM2x4LnToawxgx022YE45z-UQDLfsy41AvIu3TjDnMS0aacZfw9oS86Koevn6ox-T67OvV6Xlz-f3bxemXyyZKo-aGITdGOWe5VEwpJkQULa5brbQLrQ0AVivJAWLn1twBawUyJYPqhDbCWnFMPh90t8t6wDZWbzn0fpvTEPLeTyH5fztj-uE3084zxpV0WlaF9w8Kefq5YJn9kErEvg8jTkvx3HENpn6hqei7J-jNtOSx7ucFWOastg4qxQ9UzFMpGbtHNwz8XWz-EJuvsfn72Pydi7d_7_E48junCogDUGpr3GD-8_Z_ZH8BWd-igQ</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Coradduzza, Donatella</creator><creator>Congiargiu, Antonella</creator><creator>Azara, Emanuela</creator><creator>Mammani, Ismaeil Mohammed Abulkahar</creator><creator>De Miglio, Maria Rosaria</creator><creator>Zinellu, Angelo</creator><creator>Carru, Ciriaco</creator><creator>Medici, Serenella</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>JG9</scope><scope>K9.</scope><scope>L7M</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240801</creationdate><title>Heavy metals in biological samples of cancer patients: a systematic literature review</title><author>Coradduzza, Donatella ; 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Some of them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) and nickel (Ni)) have been defined as carcinogens, increasing the susceptibility of tumor development and progression in humans. Moreover, Ni, Cr, Cd, Hg, and Pb together with zinc (Zn) and iron (Fe), may be capable of stimulating the progression of breast cancer and reducing a patient’s sensitivity to treatment through alterations to DNA methylation. In patients with gastric cancers, levels of various heavy metals are augmented and hypothesized to amplify the expression of the human epidermal growth factor receptor type 2 gene. Cd may increase the risk of lung cancer development and have a negative impact on the overall survival of lung cancer patients. To investigate the relation between heavy metals in biological samples and risk, occurrence and survival cancer individuals, a comprehensive review work was performed, with a focus on breast, lung, prostate and gastric cancers. An extensive search strategy was devised to ensure relevant literature could be identified, with the PECO framework being adopted to facilitate this and identify key search terms. As evidenced in this review, there is substantial data to support the hypothesis that heavy metals influence tumor development and progression. Unluckily the number of papers dealing with the determination of metals directly in samples from cancer tissues is still rather limited, so we decided to expand the scope of this review also to analyses carried out on other biological samples, as urine, plasma, hair, nail, etc. The studies reviewed showed that several limitations and current knowledge gaps are present in the literature that require further investigation to improve our comprehension of the impact of different heavy metals on tumorigenesis.
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| subjects | Arsenic Biochemistry Biological properties Biological samples Biomedical and Life Sciences Breast cancer Cadmium Carcinogenesis Carcinogens Cell Biology Chromium DNA methylation Gene expression Growth factors Heavy metals Iron Lead Life Sciences Literature reviews Lung cancer Medicine/Public Health Mercury Mercury (metal) Microbiology Nickel Pharmacology/Toxicology Plant Physiology Review Search methods Survival Tumorigenesis Tumors |
| title | Heavy metals in biological samples of cancer patients: a systematic literature review |
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