The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center

Translation termination is an essential cellular process, which is also of therapeutic interest for diseases that manifest from premature stop codons. In eukaryotes, translation termination requires eRF1, which recognizes stop codons, catalyzes the release of nascent proteins from ribosomes and faci...

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Veröffentlicht in:	Nature chemical biology 2024-07, Vol.20 (7), p.877-884
Hauptverfasser:	Coelho, João P. L., Yip, Matthew C. J., Oltion, Keely, Taunton, Jack, Shao, Sichen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/574 631/535 631/92/609 631/92/610 Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Codon, Terminator - genetics Codons Cryoelectron Microscopy Degradation Eukaryotes Humans Models, Molecular Peptide Chain Termination, Translational Peptide Termination Factors - chemistry Peptide Termination Factors - genetics Peptide Termination Factors - metabolism Protein Biosynthesis Ribonucleic acid Ribosomes Ribosomes - genetics Ribosomes - metabolism RNA Stop codon Translation termination Ubiquitin Ubiquitination
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