PHACTboost: A Phylogeny-Aware Pathogenicity Predictor for Missense Mutations via Boosting

Abstract Most algorithms that are used to predict the effects of variants rely on evolutionary conservation. However, a majority of such techniques compute evolutionary conservation by solely using the alignment of multiple sequences while overlooking the evolutionary context of substitution events....

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Veröffentlicht in:	Molecular biology and evolution 2024-07, Vol.41 (7)
Hauptverfasser:	Dereli, Onur, Kuru, Nurdan, Akkoyun, Emrah, Bircan, Aylin, Tastan, Oznur, Adebali, Ogün
Format:	Artikel
Sprache:	eng
Schlagworte:	Methods
Online-Zugang:	Volltext
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