In Vivo Delivery of Spherical and Cylindrical In Vitro Reconstituted Virus-like Particles Containing the Same Self-Amplifying mRNA

The dramatic effectiveness of recent mRNA (mRNA)-based COVID vaccines delivered in lipid nanoparticles has highlighted the promise of mRNA therapeutics in general. In this report, we extend our earlier work on self-amplifying mRNAs delivered in spherical in vitro reconstituted virus-like particles (...

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Veröffentlicht in:	Molecular pharmaceutics 2024-06, Vol.21 (6), p.2727-2739
Hauptverfasser:	Karan, Sweta, Durán-Meza, Ana Luisa, Chapman, Abigail, Tanimoto, Cheylene, Chan, Soo Khim, Knobler, Charles M., Gelbart, William M., Steinmetz, Nicole F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromovirus - genetics Capsid Proteins - genetics COVID-19 Vaccines - administration & dosage Female Humans Liposomes Mice Nanoparticles - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Dependent RNA Polymerase - genetics RNA-Dependent RNA Polymerase - metabolism Tobacco Mosaic Virus - genetics Vaccines, Virus-Like Particle - administration & dosage Virion - genetics
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