Fluvoxamine Exerts Sigma-1R to Rescue Autophagy via Pom121-Mediated Nucleocytoplasmic Transport of TFEB

Expansion of the GGGGCC-RNA repeat is a known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which currently have no cure. Recent studies have indicated the activation of Sigma-1 receptor plays an important role in providing neuroprotection, especially in ALS and Alz...

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Veröffentlicht in:	Molecular neurobiology 2024-08, Vol.61 (8), p.5282-5294
Hauptverfasser:	Lin, Chun-Yu, Wu, Hsiang-En, Weng, Eddie Feng-Ju, Wu, Hsuan-Cheng, Su, Tsung-Ping, Wang, Shao-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Alzheimer's disease Amyotrophic lateral sclerosis Animals Autophagy Autophagy - drug effects Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Biomedical and Life Sciences Biomedicine C9orf72 Protein - genetics C9orf72 Protein - metabolism Cell Biology Cell death Cell Line Cell Nucleus - drug effects Cell Nucleus - metabolism Dementia disorders Fluvoxamine Fluvoxamine - pharmacology Frontotemporal dementia Humans Mice Neurobiology Neurodegenerative diseases Neurology Neuroprotection Neurosciences Nuclear transport Protein expression Receptors, sigma - metabolism Ribonucleic acid RNA RNA transport Sigma-1 Receptor
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