Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity

Viruses employ a range of strategies to counteract the prokaryotic adaptive immune system, clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR–Cas), including mutational escape and physical blocking of enzymatic function using anti-CRISPR proteins (Acrs)....

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Veröffentlicht in:	Nature microbiology 2018-04, Vol.3 (4), p.461-469
Hauptverfasser:	He, Fei, Bhoobalan-Chitty, Yuvaraj, Van, Lan B., Kjeldsen, Anders L., Dedola, Matteo, Makarova, Kira S., Koonin, Eugene V., Brodersen, Ditlev E., Peng, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/26/2523 631/326/596/2558 631/337 82 82/16 82/80 82/83 Biomedical and Life Sciences CRISPR CRISPR-Associated Proteins - antagonists & inhibitors CRISPR-Associated Proteins - metabolism CRISPR-Cas Systems - physiology Genomes Immune system Infectious Diseases Infectivity Insertion Life Sciences Medical Microbiology Microbiology Parasitology Phages Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Rudiviridae - genetics Rudiviridae - pathogenicity Structure-function relationships Sulfolobus - genetics Sulfolobus - virology Virology Viruses
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