Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction

BACKGROUND Alzheimer's disease (AD) is the most common cause of dementia worldwide, with apolipoprotein Eε4 (APOEε4) being the strongest genetic risk factor. Current clinical diagnostic imaging focuses on amyloid and tau; however, new methods are needed for earlier detection. METHODS PET imagin...

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Veröffentlicht in:	Alzheimer's & dementia 2024-07, Vol.20 (7), p.4951-4969
Hauptverfasser:	Onos, Kristen D., Lin, Peter B., Pandey, Ravi S., Persohn, Scott A., Burton, Charles P., Miner, Ethan W., Eldridge, Kierra, Kanyinda, Jonathan Nyandu, Foley, Kate E., Carter, Gregory W., Howell, Gareth R., Territo, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease APOE metabolism perfusion uncoupling
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