INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death

microRNAs (miRNAs) are small, non-coding RNAs that regulate expression of multiple genes. MiR-193a-3p functions as a tumor suppressor in many cancer types, but its effect on inducing specific anti-tumor immune responses is unclear. Therefore, we examined the effect of our lipid nanoparticle (LNP) fo...

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Veröffentlicht in:	Oncotarget 2024-07, Vol.15 (1), p.470-485
Hauptverfasser:	Duurland, Chantal L, Gunst, Thijs de, Boer, Harm C den, Bosch, Marion T J van den, Telford, Bryony J, Vos, Rogier M, Xie, Xiaolei, Zang, Mingfa, Wang, Fang, Shao, Yingying, An, Xiaoyu, Wang, Jingjing, Cai, Jie, Bourré, Ludovic, Pinxteren, Laurens A H van, Schaapveld, Roel Q J, Janicot, Michel, Yahyanejad, Sanaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cytokines - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Female Humans Immunity, Cellular Immunogenic Cell Death - drug effects Liposomes Mice Mice, Inbred C57BL MicroRNAs - genetics Nanoparticles - chemistry Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Research Paper T-Lymphocytes - immunology T-Lymphocytes - metabolism Transfection Tumor Microenvironment - immunology
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