Metabolic programs of T cell tissue residency empower tumour immunity

Tissue resident memory CD8 + T (T RM ) cells offer rapid and long-term protection at sites of reinfection 1 . Tumour-infiltrating lymphocytes with characteristics of T RM cells maintain enhanced effector functions, predict responses to immunotherapy and accompany better prognoses 2 , 3 . Thus, an im...

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Veröffentlicht in:	Nature (London) 2023-09, Vol.621 (7977), p.179-187
Hauptverfasser:	Reina-Campos, Miguel, Heeg, Maximilian, Kennewick, Kelly, Mathews, Ian T., Galletti, Giovanni, Luna, Vida, Nguyen, Quynhanh, Huang, Hongling, Milner, J. Justin, Hu, Kenneth H., Vichaidit, Amy, Santillano, Natalie, Boland, Brigid S., Chang, John T., Jain, Mohit, Sharma, Sonia, Krummel, Matthew F., Chi, Hongbo, Bensinger, Steven J., Goldrath, Ananda W.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/31 14/19 38/39 38/47 38/91 42/41 631/250/2152/1566/1571 631/250/254 631/250/347 631/45/320 631/67/327 64/110 82/58 Adaptation Animals CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell differentiation Cell Respiration Cell survival Cholesterol Cholesterol - metabolism Cholesterol - pharmacology Coenzyme Q CRISPR Differentiation (biology) Effector cells Empowerment Enzymes Genes Genomics Humanities and Social Sciences Humans Immunity Immunologic Memory Immunological memory Immunotherapy Infections Intestine Intestine, Small - drug effects Intestine, Small - metabolism Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Memory cells Metabolism Metabolites Metabolomics Mevalonic Acid - metabolism Mice Mitochondria - metabolism multidisciplinary Neoplasms - immunology Proteins Science Science (multidisciplinary) Small intestine Solid tumors Spleen T cell receptors Tissues Transcription factors Transcriptomics Tumors Ubiquinone - metabolism Viral infections Virus Diseases - immunology Viruses - immunology
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