Development of osteonecrosis and improved survival in B-ALL: results of Children’s Oncology Group Trial AALL0232

Osteonecrosis is a significant toxicity of acute lymphoblastic leukemia (ALL) therapy. In retrospective analyses, superior event-free survival was noted among affected adolescents in an earlier trial. We prospectively assessed osteonecrosis incidence, characteristics, and risk factors in patients 1–...

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Veröffentlicht in:	Leukemia 2024-02, Vol.38 (2), p.258-265
Hauptverfasser:	Mattano, Leonard A., Devidas, Meenakshi, Loh, Mignon L., Raetz, Elizabeth A., Chen, Zhiguo, Winick, Naomi J., Hunger, Stephen P., Carroll, William L., Larsen, Eric C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/99 692/308/2779/777 692/699/67/1990/283/2125 Acute lymphoblastic leukemia Adolescent Allergies Antineoplastic Combined Chemotherapy Protocols - adverse effects Asparaginase Cancer Research Child Critical Care Medicine Dexamethasone Disease-Free Survival Female Hematology Humans Intensive Internal Medicine Leukemia Lymphatic leukemia Medicine Medicine & Public Health Methotrexate Necrosis Oncology Osteonecrosis Osteonecrosis - chemically induced Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma Prednisone Prednisone - adverse effects Retrospective Studies Risk factors Survival Toxicity
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