Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration

Macrocyclic drugs can address an increasing range of molecular targets but enabling central nervous system (CNS) access to these drugs has been viewed as an intractable problem. We designed and synthesized a series of quinolinium-modified cyclosporine derivatives targeted to the mitochondrial cyclop...

Ausführliche Beschreibung