Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma
Hepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover,...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2024-07, Vol.28 (13), p.e18496-n/a |
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| creator | Yuan, Xiao Wang, Yida Jiao, Sitong Gao, Huanhuan Zhang, Mengqian Wang, Xin Zhou, Xunyu Wu, Chuanfang Bao, Jinku |
| description | Hepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non‐coding RNAs (lncRNAs) and mRNAs is pivotal in various physiological and pathological processes, their involvement in ferroptosis remains relatively unexplored. In this study, we constructed a ferroptosis‐related lncRNA‐mRNA correlation network in HCC using Pearson correlation analysis. Notably, the SLC7A11‐AS1/SLC7A11 pair, exhibiting high correlation, was identified. Bioinformatics analysis revealed a significant correlation between the expression levels of this pair and key clinical characteristics of HCC patients, including gender, pathology, Ishak scores and tumour size. And poor prognosis was associated with high expression of this pair. Functional experiments demonstrated that SLC7A11‐AS1, by binding to the 3′UTR region of SLC7A11 mRNA, enhanced its stability, thereby promoting HCC cell growth and resistance to erastin‐ induced ferroptosis. Additionally, in vivo studies confirmed that SLC7A11‐AS1 knockdown potentiated the inhibitory effects of erastin on tumour growth. Overall, our findings suggest that targeting the SLC7A11‐AS1/SLC7A11 pair holds promise as a potential therapeutic strategy for HCC patients. |
| doi_str_mv | 10.1111/jcmm.18496 |
| format | Article |
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Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non‐coding RNAs (lncRNAs) and mRNAs is pivotal in various physiological and pathological processes, their involvement in ferroptosis remains relatively unexplored. In this study, we constructed a ferroptosis‐related lncRNA‐mRNA correlation network in HCC using Pearson correlation analysis. Notably, the SLC7A11‐AS1/SLC7A11 pair, exhibiting high correlation, was identified. Bioinformatics analysis revealed a significant correlation between the expression levels of this pair and key clinical characteristics of HCC patients, including gender, pathology, Ishak scores and tumour size. And poor prognosis was associated with high expression of this pair. Functional experiments demonstrated that SLC7A11‐AS1, by binding to the 3′UTR region of SLC7A11 mRNA, enhanced its stability, thereby promoting HCC cell growth and resistance to erastin‐ induced ferroptosis. Additionally, in vivo studies confirmed that SLC7A11‐AS1 knockdown potentiated the inhibitory effects of erastin on tumour growth. Overall, our findings suggest that targeting the SLC7A11‐AS1/SLC7A11 pair holds promise as a potential therapeutic strategy for HCC patients.</description><identifier>ISSN: 1582-1838</identifier><identifier>ISSN: 1582-4934</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.18496</identifier><identifier>PMID: 38984939</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>3' Untranslated regions ; Amino Acid Transport System y+ - genetics ; Amino Acid Transport System y+ - metabolism ; Animals ; Antibodies ; Apoptosis ; Bioinformatics ; Cancer therapies ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell culture ; Cell cycle ; Cell death ; Cell Line, Tumor ; Cell Proliferation - genetics ; Chemotherapy ; Cloning ; Correlation analysis ; Female ; Ferroptosis ; Ferroptosis - genetics ; Flow cytometry ; Gene expression ; Gene Expression Regulation, Neoplastic ; Hepatocellular carcinoma ; Humans ; Lipid peroxidation ; Lipids ; Liver cancer ; Liver Neoplasms - drug therapy ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; lncRNA‐mRNA correlation network ; Male ; Malignancy ; Medical innovations ; Medical prognosis ; Metabolism ; Mice ; Mice, Nude ; Middle Aged ; mRNA stability ; Non-coding RNA ; Original ; Oxidative stress ; Piperazines - pharmacology ; Prognosis ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; SLC7A11 ; SLC7A11‐AS1 ; Therapeutic targets ; Tumors</subject><ispartof>Journal of cellular and molecular medicine, 2024-07, Vol.28 (13), p.e18496-n/a</ispartof><rights>2024 The Author(s). published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3386-157ada022cfd49a49a54ca87baf3f4edbea97f7ffdcd1144a30b2786447d1a373</cites><orcidid>0009-0004-4722-7656</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234646/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234646/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38984939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Xiao</creatorcontrib><creatorcontrib>Wang, Yida</creatorcontrib><creatorcontrib>Jiao, Sitong</creatorcontrib><creatorcontrib>Gao, Huanhuan</creatorcontrib><creatorcontrib>Zhang, Mengqian</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Zhou, Xunyu</creatorcontrib><creatorcontrib>Wu, Chuanfang</creatorcontrib><creatorcontrib>Bao, Jinku</creatorcontrib><title>Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Hepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non‐coding RNAs (lncRNAs) and mRNAs is pivotal in various physiological and pathological processes, their involvement in ferroptosis remains relatively unexplored. In this study, we constructed a ferroptosis‐related lncRNA‐mRNA correlation network in HCC using Pearson correlation analysis. Notably, the SLC7A11‐AS1/SLC7A11 pair, exhibiting high correlation, was identified. Bioinformatics analysis revealed a significant correlation between the expression levels of this pair and key clinical characteristics of HCC patients, including gender, pathology, Ishak scores and tumour size. And poor prognosis was associated with high expression of this pair. Functional experiments demonstrated that SLC7A11‐AS1, by binding to the 3′UTR region of SLC7A11 mRNA, enhanced its stability, thereby promoting HCC cell growth and resistance to erastin‐ induced ferroptosis. Additionally, in vivo studies confirmed that SLC7A11‐AS1 knockdown potentiated the inhibitory effects of erastin on tumour growth. Overall, our findings suggest that targeting the SLC7A11‐AS1/SLC7A11 pair holds promise as a potential therapeutic strategy for HCC patients.</description><subject>3' Untranslated regions</subject><subject>Amino Acid Transport System y+ - genetics</subject><subject>Amino Acid Transport System y+ - metabolism</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Bioinformatics</subject><subject>Cancer therapies</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - genetics</subject><subject>Chemotherapy</subject><subject>Cloning</subject><subject>Correlation analysis</subject><subject>Female</subject><subject>Ferroptosis</subject><subject>Ferroptosis - genetics</subject><subject>Flow cytometry</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>lncRNA‐mRNA correlation network</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical innovations</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Middle Aged</subject><subject>mRNA stability</subject><subject>Non-coding RNA</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Piperazines - pharmacology</subject><subject>Prognosis</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>SLC7A11</subject><subject>SLC7A11‐AS1</subject><subject>Therapeutic targets</subject><subject>Tumors</subject><issn>1582-1838</issn><issn>1582-4934</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFuEzEQhi0EoqVw4QGQJS6oUtqdtbO2TyiKKBSl4lA4WxOv3TjaXS-2t1VvPALPyJPgkFABB0YjeUb-9Gt-_YS8hOoMSp1vTd-fgeSqeUSOYS7rGVeMPz7MIJk8Is9S2lYVa4Cpp-SISVVwpo7J3WVrh-ydN5h9GGhw9Hq1FAuAH9--L67h_LDREX2kmChSZ2MMYw7Jp8JE22G2Lc0bG3G0U_aGZow3NlMXIt3YEXMwtuumDiM1GI0fQo_PyROHXbIvDu8J-XLx7vPyw2z16f3lcrGaGcZkM4O5wBarujau5QpLz7lBKdbomOO2XVtUwgnnWtMCcI6sWtdCNpyLFpAJdkLe7nXHad3b1hSzETs9Rt9jvNcBvf77Z_AbfRNuNUDNeMObovDmoBDD18mmrHufdoZwsGFKmlVCKDWvFSvo63_QbZjiUPwVSkJVStaFOt1TJoaUonUP10Cld4HqXaD6V6AFfvXn_Q_o7wQLAHvgznf2_j9S-uPy6mov-hNxQ66W</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Yuan, Xiao</creator><creator>Wang, Yida</creator><creator>Jiao, Sitong</creator><creator>Gao, Huanhuan</creator><creator>Zhang, Mengqian</creator><creator>Wang, Xin</creator><creator>Zhou, Xunyu</creator><creator>Wu, Chuanfang</creator><creator>Bao, Jinku</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0004-4722-7656</orcidid></search><sort><creationdate>202407</creationdate><title>Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma</title><author>Yuan, Xiao ; Wang, Yida ; Jiao, Sitong ; Gao, Huanhuan ; Zhang, Mengqian ; Wang, Xin ; Zhou, Xunyu ; Wu, Chuanfang ; Bao, Jinku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3386-157ada022cfd49a49a54ca87baf3f4edbea97f7ffdcd1144a30b2786447d1a373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>3' Untranslated regions</topic><topic>Amino Acid Transport System y+ - genetics</topic><topic>Amino Acid Transport System y+ - metabolism</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Apoptosis</topic><topic>Bioinformatics</topic><topic>Cancer therapies</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell culture</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - genetics</topic><topic>Chemotherapy</topic><topic>Cloning</topic><topic>Correlation analysis</topic><topic>Female</topic><topic>Ferroptosis</topic><topic>Ferroptosis - genetics</topic><topic>Flow cytometry</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>lncRNA‐mRNA correlation network</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical innovations</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Middle Aged</topic><topic>mRNA stability</topic><topic>Non-coding RNA</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Piperazines - pharmacology</topic><topic>Prognosis</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>SLC7A11</topic><topic>SLC7A11‐AS1</topic><topic>Therapeutic targets</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Xiao</creatorcontrib><creatorcontrib>Wang, Yida</creatorcontrib><creatorcontrib>Jiao, Sitong</creatorcontrib><creatorcontrib>Gao, Huanhuan</creatorcontrib><creatorcontrib>Zhang, Mengqian</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Zhou, Xunyu</creatorcontrib><creatorcontrib>Wu, Chuanfang</creatorcontrib><creatorcontrib>Bao, Jinku</creatorcontrib><collection>Wiley Online Library</collection><collection>Wiley Online Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Xiao</au><au>Wang, Yida</au><au>Jiao, Sitong</au><au>Gao, Huanhuan</au><au>Zhang, Mengqian</au><au>Wang, Xin</au><au>Zhou, Xunyu</au><au>Wu, Chuanfang</au><au>Bao, Jinku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2024-07</date><risdate>2024</risdate><volume>28</volume><issue>13</issue><spage>e18496</spage><epage>n/a</epage><pages>e18496-n/a</pages><issn>1582-1838</issn><issn>1582-4934</issn><eissn>1582-4934</eissn><abstract>Hepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non‐coding RNAs (lncRNAs) and mRNAs is pivotal in various physiological and pathological processes, their involvement in ferroptosis remains relatively unexplored. In this study, we constructed a ferroptosis‐related lncRNA‐mRNA correlation network in HCC using Pearson correlation analysis. Notably, the SLC7A11‐AS1/SLC7A11 pair, exhibiting high correlation, was identified. Bioinformatics analysis revealed a significant correlation between the expression levels of this pair and key clinical characteristics of HCC patients, including gender, pathology, Ishak scores and tumour size. And poor prognosis was associated with high expression of this pair. Functional experiments demonstrated that SLC7A11‐AS1, by binding to the 3′UTR region of SLC7A11 mRNA, enhanced its stability, thereby promoting HCC cell growth and resistance to erastin‐ induced ferroptosis. Additionally, in vivo studies confirmed that SLC7A11‐AS1 knockdown potentiated the inhibitory effects of erastin on tumour growth. Overall, our findings suggest that targeting the SLC7A11‐AS1/SLC7A11 pair holds promise as a potential therapeutic strategy for HCC patients.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>38984939</pmid><doi>10.1111/jcmm.18496</doi><tpages>16</tpages><orcidid>https://orcid.org/0009-0004-4722-7656</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 3' Untranslated regions Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Animals Antibodies Apoptosis Bioinformatics Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell culture Cell cycle Cell death Cell Line, Tumor Cell Proliferation - genetics Chemotherapy Cloning Correlation analysis Female Ferroptosis Ferroptosis - genetics Flow cytometry Gene expression Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Humans Lipid peroxidation Lipids Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology lncRNA‐mRNA correlation network Male Malignancy Medical innovations Medical prognosis Metabolism Mice Mice, Nude Middle Aged mRNA stability Non-coding RNA Original Oxidative stress Piperazines - pharmacology Prognosis RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism SLC7A11 SLC7A11‐AS1 Therapeutic targets Tumors |
| title | Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma |
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