Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils
First- (monomers), second- (pre-gelated), and third- (in situ gelating after injection) generation hydrogels were previously introduced to replace the vitreous body after vitrectomy surgery. In this study, we evaluated the surgical, optical, and viscoelastic properties of vitreous body replacement h...
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| Veröffentlicht in: | Translational vision science & technology 2024-07, Vol.13 (7), p.5 |
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| creator | Hammer, Maximilian Muuss, Marcel Herbster, Lorenz Herth, Jonathan Scheuerle, Alexander Khoramnia, Ramin Labuz, Grzegorz Uhl, Philipp Auffarth, Gerd Uwe |
| description | First- (monomers), second- (pre-gelated), and third- (in situ gelating after injection) generation hydrogels were previously introduced to replace the vitreous body after vitrectomy surgery. In this study, we evaluated the surgical, optical, and viscoelastic properties of vitreous body replacement hydrogels before and after an accelerated aging protocol previously applied to intraocular implants.
Measurements of injection force, removal speed using a clinically established vitrectomy setup, as well as evaluation of forward light scattering and viscoelastic properties before and after an accelerated aging protocol were conducted. Results were compared to porcine and human vitreous bodies, as well as currently clinically applied lighter- and heavier-than-water silicone oils.
Removal speed of all tested hydrogels is substantially lower than the removal speed of porcine vitreous body (0.2 g/min vs. 2.7 g/min for the best performing hydrogel and porcine vitreous body, respectively). Forward light scattering in second-generation vitreous body replacement hydrogels was higher after the aging process than the straylight of the average 70-year-old vitreous body (9.4 vs. 5.5 deg2/sr, respectively). The viscoelastic properties of all hydrogels did not change in a clinically meaningful manner; however, trends toward greater stiffness and greater elasticity after aging were apparent.
This study demonstrates surgical weaknesses of the hydrogels that need to be addressed before clinical use, especially low removal speed. Pre-linked hydrogels (second-generation) showed inferior performance regarding surgical properties compared to in situ gelating hydrogels (third-generation).
This study highlights possible pitfalls regarding surgical and optical properties when applying vitreous replacement hydrogels clinically. |
| doi_str_mv | 10.1167/tvst.13.7.5 |
| format | Article |
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Measurements of injection force, removal speed using a clinically established vitrectomy setup, as well as evaluation of forward light scattering and viscoelastic properties before and after an accelerated aging protocol were conducted. Results were compared to porcine and human vitreous bodies, as well as currently clinically applied lighter- and heavier-than-water silicone oils.
Removal speed of all tested hydrogels is substantially lower than the removal speed of porcine vitreous body (0.2 g/min vs. 2.7 g/min for the best performing hydrogel and porcine vitreous body, respectively). Forward light scattering in second-generation vitreous body replacement hydrogels was higher after the aging process than the straylight of the average 70-year-old vitreous body (9.4 vs. 5.5 deg2/sr, respectively). The viscoelastic properties of all hydrogels did not change in a clinically meaningful manner; however, trends toward greater stiffness and greater elasticity after aging were apparent.
This study demonstrates surgical weaknesses of the hydrogels that need to be addressed before clinical use, especially low removal speed. Pre-linked hydrogels (second-generation) showed inferior performance regarding surgical properties compared to in situ gelating hydrogels (third-generation).
This study highlights possible pitfalls regarding surgical and optical properties when applying vitreous replacement hydrogels clinically.</description><identifier>ISSN: 2164-2591</identifier><identifier>EISSN: 2164-2591</identifier><identifier>DOI: 10.1167/tvst.13.7.5</identifier><identifier>PMID: 38967936</identifier><language>eng</language><publisher>United States: The Association for Research in Vision and Ophthalmology</publisher><subject>Aged ; Aging - physiology ; Animals ; Elasticity ; Humans ; Hydrogels - chemistry ; Retina ; Silicone Oils - chemistry ; Swine ; Viscosity ; Vitrectomy - methods ; Vitreous Body - surgery</subject><ispartof>Translational vision science & technology, 2024-07, Vol.13 (7), p.5</ispartof><rights>Copyright 2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-43c631d7574093a61547474077a28051f5670a9b8646086f5efddaa2a1a246f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232910/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232910/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38967936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammer, Maximilian</creatorcontrib><creatorcontrib>Muuss, Marcel</creatorcontrib><creatorcontrib>Herbster, Lorenz</creatorcontrib><creatorcontrib>Herth, Jonathan</creatorcontrib><creatorcontrib>Scheuerle, Alexander</creatorcontrib><creatorcontrib>Khoramnia, Ramin</creatorcontrib><creatorcontrib>Labuz, Grzegorz</creatorcontrib><creatorcontrib>Uhl, Philipp</creatorcontrib><creatorcontrib>Auffarth, Gerd Uwe</creatorcontrib><title>Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils</title><title>Translational vision science & technology</title><addtitle>Transl Vis Sci Technol</addtitle><description>First- (monomers), second- (pre-gelated), and third- (in situ gelating after injection) generation hydrogels were previously introduced to replace the vitreous body after vitrectomy surgery. In this study, we evaluated the surgical, optical, and viscoelastic properties of vitreous body replacement hydrogels before and after an accelerated aging protocol previously applied to intraocular implants.
Measurements of injection force, removal speed using a clinically established vitrectomy setup, as well as evaluation of forward light scattering and viscoelastic properties before and after an accelerated aging protocol were conducted. Results were compared to porcine and human vitreous bodies, as well as currently clinically applied lighter- and heavier-than-water silicone oils.
Removal speed of all tested hydrogels is substantially lower than the removal speed of porcine vitreous body (0.2 g/min vs. 2.7 g/min for the best performing hydrogel and porcine vitreous body, respectively). Forward light scattering in second-generation vitreous body replacement hydrogels was higher after the aging process than the straylight of the average 70-year-old vitreous body (9.4 vs. 5.5 deg2/sr, respectively). The viscoelastic properties of all hydrogels did not change in a clinically meaningful manner; however, trends toward greater stiffness and greater elasticity after aging were apparent.
This study demonstrates surgical weaknesses of the hydrogels that need to be addressed before clinical use, especially low removal speed. Pre-linked hydrogels (second-generation) showed inferior performance regarding surgical properties compared to in situ gelating hydrogels (third-generation).
This study highlights possible pitfalls regarding surgical and optical properties when applying vitreous replacement hydrogels clinically.</description><subject>Aged</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Elasticity</subject><subject>Humans</subject><subject>Hydrogels - chemistry</subject><subject>Retina</subject><subject>Silicone Oils - chemistry</subject><subject>Swine</subject><subject>Viscosity</subject><subject>Vitrectomy - methods</subject><subject>Vitreous Body - surgery</subject><issn>2164-2591</issn><issn>2164-2591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1r3DAQhkVpaUKaU-9Fx0KzW41lSfapbJcmKQQ29CNXochjV0W2XEkb2F_Sv1uZpCHRHEbDvDyj0UvIW2BrAKk-5ruU18DXai1ekOMKZL2qRAsvn9yPyGlKv1k5shF1LV-TI960UrVcHpO_Ny7ZgN6k7OwZ3c0lGX9GzdTR7_s4LBW9jmHGmB0mGnp643LEsE_0c-gO9BvO3lgcccr08tDFMKBPdNNnjHQzuGmg2zDOJmJHc6DXIVo34TPGgt0s45x3NpTmzvn0hrzqjU94-pBPyM_zLz-2l6ur3cXX7eZqZSvF8qrmVnLolFA1a7mRIGpVgillqoYJ6IVUzLS3jawla2QvsO86YyoDpqplD_yEfLrnzvvbETtb1ojG6zm60cSDDsbp553J_dJDuNMAFa9aYIXw_oEQw589pqzH8qXovZmWDTVnSjJompYX6Yd7qY0hpYj94xxgerFTL3Zq4FppUdTvnj7tUfvfPP4Piu-dxA</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Hammer, Maximilian</creator><creator>Muuss, Marcel</creator><creator>Herbster, Lorenz</creator><creator>Herth, Jonathan</creator><creator>Scheuerle, Alexander</creator><creator>Khoramnia, Ramin</creator><creator>Labuz, Grzegorz</creator><creator>Uhl, Philipp</creator><creator>Auffarth, Gerd Uwe</creator><general>The Association for Research in Vision and Ophthalmology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240701</creationdate><title>Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils</title><author>Hammer, Maximilian ; Muuss, Marcel ; Herbster, Lorenz ; Herth, Jonathan ; Scheuerle, Alexander ; Khoramnia, Ramin ; Labuz, Grzegorz ; Uhl, Philipp ; Auffarth, Gerd Uwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-43c631d7574093a61547474077a28051f5670a9b8646086f5efddaa2a1a246f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Elasticity</topic><topic>Humans</topic><topic>Hydrogels - chemistry</topic><topic>Retina</topic><topic>Silicone Oils - chemistry</topic><topic>Swine</topic><topic>Viscosity</topic><topic>Vitrectomy - methods</topic><topic>Vitreous Body - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammer, Maximilian</creatorcontrib><creatorcontrib>Muuss, Marcel</creatorcontrib><creatorcontrib>Herbster, Lorenz</creatorcontrib><creatorcontrib>Herth, Jonathan</creatorcontrib><creatorcontrib>Scheuerle, Alexander</creatorcontrib><creatorcontrib>Khoramnia, Ramin</creatorcontrib><creatorcontrib>Labuz, Grzegorz</creatorcontrib><creatorcontrib>Uhl, Philipp</creatorcontrib><creatorcontrib>Auffarth, Gerd Uwe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational vision science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammer, Maximilian</au><au>Muuss, Marcel</au><au>Herbster, Lorenz</au><au>Herth, Jonathan</au><au>Scheuerle, Alexander</au><au>Khoramnia, Ramin</au><au>Labuz, Grzegorz</au><au>Uhl, Philipp</au><au>Auffarth, Gerd Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils</atitle><jtitle>Translational vision science & technology</jtitle><addtitle>Transl Vis Sci Technol</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>13</volume><issue>7</issue><spage>5</spage><pages>5-</pages><issn>2164-2591</issn><eissn>2164-2591</eissn><abstract>First- (monomers), second- (pre-gelated), and third- (in situ gelating after injection) generation hydrogels were previously introduced to replace the vitreous body after vitrectomy surgery. In this study, we evaluated the surgical, optical, and viscoelastic properties of vitreous body replacement hydrogels before and after an accelerated aging protocol previously applied to intraocular implants.
Measurements of injection force, removal speed using a clinically established vitrectomy setup, as well as evaluation of forward light scattering and viscoelastic properties before and after an accelerated aging protocol were conducted. Results were compared to porcine and human vitreous bodies, as well as currently clinically applied lighter- and heavier-than-water silicone oils.
Removal speed of all tested hydrogels is substantially lower than the removal speed of porcine vitreous body (0.2 g/min vs. 2.7 g/min for the best performing hydrogel and porcine vitreous body, respectively). Forward light scattering in second-generation vitreous body replacement hydrogels was higher after the aging process than the straylight of the average 70-year-old vitreous body (9.4 vs. 5.5 deg2/sr, respectively). The viscoelastic properties of all hydrogels did not change in a clinically meaningful manner; however, trends toward greater stiffness and greater elasticity after aging were apparent.
This study demonstrates surgical weaknesses of the hydrogels that need to be addressed before clinical use, especially low removal speed. Pre-linked hydrogels (second-generation) showed inferior performance regarding surgical properties compared to in situ gelating hydrogels (third-generation).
This study highlights possible pitfalls regarding surgical and optical properties when applying vitreous replacement hydrogels clinically.</abstract><cop>United States</cop><pub>The Association for Research in Vision and Ophthalmology</pub><pmid>38967936</pmid><doi>10.1167/tvst.13.7.5</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aged Aging - physiology Animals Elasticity Humans Hydrogels - chemistry Retina Silicone Oils - chemistry Swine Viscosity Vitrectomy - methods Vitreous Body - surgery |
| title | Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils |
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