Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity

SLC15A4 is an endolysosome-resident transporter linked with autoinflammation and autoimmunity. Specifically, SLC15A4 is critical for Toll-like receptors (TLRs) 7–9 as well as nucleotide-binding oligomerization domain-containing protein (NOD) signaling in several immune cell subsets. Notably, SLC15A4...

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Veröffentlicht in:	Nature chemical biology 2024-01, Vol.20 (8), p.1000-1011
Hauptverfasser:	Chiu, Tzu-Yuan, Lazar, Daniel C., Wang, Wesley W., Wozniak, Jacob M., Jadhav, Appaso M., Li, Weichao, Gazaniga, Nathalia, Theofilopoulos, Argyrios N., Teijaro, John R., Parker, Christopher G.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/86 631/92/507 631/92/577 631/92/613 692/699/249 Animal models Anti-inflammatory agents Autoimmune diseases Autoimmunity Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Chronic conditions Functionals Human performance Immune system In vivo methods and tests Inhibitors Ligands Lupus Nucleotides Oligomerization Peptides Proteins Proteomics Systemic lupus erythematosus Toll-like receptors
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